DNA copy number change
let 7b/g silencing activates AKT signaling to promote gastric carcinogenesis
... Genomic DNA copy number alterations [26] and DNA methylation [27] are also responsible for the decreased expression of let-7 family in ...the DNA copy number change ...
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Genome-wide analysis of DNA copy-number changes using cDNA microarrays.pdf
... in DNA labelling efficiency between samples, we then normalized fluorescence ratios across the array to achieve an average log ratio of 0 (average ratio of 1, that is no DNA copy-number ...
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Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women
... Mitochondrial DNA (mtDNA) located close to the source of reactive oxidative stress (ROS) production is extremely susceptible to oxidative damage due to its lack of either protective histones or introns and the ...
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Copy number variation of ribosomal DNA and Pokey transposons in natural populations of Daphnia
... gene number with TE Display, so the dynamics of rPo- key have not yet been ...R2 number remained relatively constant through time, but changes in R1 number were strongly correlated with changes in ...
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Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains
... mtDNA copy num- ber within the substantia nigra, but not frontal cortex, raising the possibility that the altered mtDNA levels are a consequence of the underlying pathology, and not the ...a change in the ...
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Increased mitochondrial DNA deletions and copy number in transfusion-dependent thalassemia
... iron supports the hypothesis that mtDNA damage in leukocytes could be useful to identify and follow patients at risk of extrahepatic iron deposition. In contrast, while higher NTBI levels were reported in patients with ...
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Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data
... in DNA cause alterations in the control of cellular systems leading to unchecked ...growth. Copy number changes, including dupli- cations, amplifications, and deletions, are a common type of ...
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CODEX2: full spectrum copy number variation detection by high throughput DNA sequencing
... with copy number c (sampled from a Gaussian distribution with mean 1 for heterozygous de- letion) and (1 − p)% cells with copy number ...the copy number change event is ...
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The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis
... a change in hearing ...Mitochondrial DNA sequence variation has a critical role in ...mitochondrial DNA copy number, an important biomarker in many other diseases, and presbycusis is ...
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Human Papillomavirus (HPV) DNA Copy Number Is Dependent on Grade of Cervical Disease and HPV Type
... significant change in copy number with increasing dysplasia, combining results for all HPV types does demonstrate an over- all correlation with disease ...sample DNA content increases with ...
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Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer
... abnormality change occurred after initiating treatments and was associated with clinical outcomes, the previously reported TEff (treatment effect) index an algorithmic score which compares the percent differences ...
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Original Article Overexpression of ANGPTL2 and LILRB2 as predictive and therapeutic biomarkers for metastasis and prognosis in colorectal cancer
... and DNA copy number variation (CNV) of LILRB2 and ANGPTL2, in the Oncomine Cancer Microarray Database ...folds change, t-test values, and p values were obtained, showing a significant ...
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Whole genome DNA copy number changes identified by high density oligonucleotide arrays
... rate. Figure 4 summarises the comparison between SPA and CPA. CPA results in a substantial shift of the receiver operating characteristic (ROC) curves toward the upper left-hand corner, indicating highly improved ...
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Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus
... necessarily change the expression or function of HNP1-3, it provides an additional landmark across a haplotype, allowing a more detailed comparison of haplotype ...for copy number change at ...
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Detecting copy number changes in genomic DNA - MAPH and MLPA
... low copy repeats can both be deleted and duplicated, and implies that the number of patients suffering from a microduplication syndrome is currently probably ...the copy number ...
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DNA Copy Number Variation in a Cohort of Healthy Australian Women
... variable number tandem repeat (VNTR) are detected using DNA sequencing methods, at an effective resolution of 1-700bp ...of DNA between these ...rapid change of these platforms was driven by ...
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DNA copy number evolution in Drosophila cell lines
... to copy number change are often deleterious at the organismal level, but are common in immortalized cell lines and tumors, where they may be an advantage to ...of copy number changes in ...
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Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients
... To proceed with trtDNA analysis, we further improved a protocol we previously employed for urine trtDNA isola- tion to enrich for tumour- derived DNA content. Specifi- cally, we performed a double- step ...
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DNA copy number alterations and PPARG amplification in a patient with multifocal bladder urothelial carcinoma
... genomic DNA extracted from the three ...the number of shared CNVs is signifi- cantly increased (Figure 3D and Additional file 2: Figure S1): 12 gains ...
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Modulation of mitochondrial DNA copy number in a model of glioblastoma induces changes to DNA methylation and gene expression of the nuclear genome in tumours
... Total DNA from the tumour samples (n = 3 per group) was submitted to the Australian Genome Research Facility (AGRF; VIC, AUS) to perform ...Nexus Copy Number Module was used to identify regions of CN ...
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