DNA damage and mutations
Aging of hematopoietic stem cells: DNA damage and mutations?
... of DNA DSBs, two distinct repair pathways are usually activated, homologous recombination (HR) and non-homologous end joining ...of DNA strands and a subsequent direct ligation of the break, NHEJ generally ...
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Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice
... and DNA damage ...induced DNA mutations in the mouse lungs [12, ...of DNA damage, such as gene mutation and DNA strand break formation, are important parts of evaluation ...
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Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations
... [4]. Mutations in mismatch repair (MMR) genes, one of many pathways involved with DNA damage repair (DDR), are associated with microsat- ellite instability in advanced prostate cancer and may serve ...
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DNA damage repair gene mutations and their association with tumor immune regulatory gene expression in muscle invasive bladder cancer subtypes
... function mutations in DNA damage repair (DDR) genes ...exhibit mutations in DDR genes ...(BRCA1/2) mutations are immunologically hot with high CD8 + TILs ...
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Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase
... a DNA translocase that helps to maintain genomic ...compromises DNA repair in a manner consistent with PriB being required to limit exposure of recombino- genic ...
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DNA Damage and Repair
... in DNA and prevent the code from being used properly. In fact, the DNA in each cell of our bodies probably sustains at least 10,000 injuries or errors each day! If DNA is like a zipper, free radicals ...
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Review on DNA damage, repair and DNA sequencing
... corrects damage to the DNA molecules that encode its ...cause DNA damage, Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ...
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Targeting DNA damage in SCLC
... 8.88 mutations per megabyte ...driver mutations, George et ...accumulating DNA damage due to replication stress [22] and genomic ...endogenous DNA replication. DNA repair ...
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Autophagy in DNA Damage Response
... mtDNA mutations, ROS and UV ...yeast mutations causing mitochondrial dysfunctions, especially these impairing the mitochondrial electrochemical transmembrane potential, have induced mitophagy even during ...
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grp (chk1) replication checkpoint mutations and DNA damage trigger a Chk2 dependent block at the Drosophila midblastula transition
... in DNA-damage signaling. Here, we show that mutations in the mnk (also known as loki – FlyBase) gene, which encodes Chk2, suppress the cellularization, gastrulation and zygotic gene-activation ...
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Phosphatases in the cellular response to DNA damage
... induce DNA breaks must be repaired in order to prevent the propa- gation of mutations that can contribute to malignant ...transformation. DNA damage occurs following a variety of stimuli ...
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DNA Damage and Its Links to Neurodegeneration
... defective DNA damage response are well studied in proliferating cells, especially with regards to the development of cancer, yet its precise roles in the nervous system are relatively poorly ...from ...
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DNA Damage, Repair, and Cancer Metabolism.
... that mutations lead to the rewiring of cancer metabolism, in fact, it may be more pertinent to question whether these mutations arise in the first place from selective pressures applied by extrinsic ...
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DNA methylation changes following DNA damage in prostate cancer cells
... increased DNA methylation observed in the PC-3 cells however, does not appear to influence susceptibility to DNA damage as PC-3 and LNCaP cells displayed similar levels of ...of DNA ...
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Regulation of DNA Damage Processing by Covalent Modification of Thymine DNA Glycosylase
... Chapter 1: Introduction 1.1 Overview Maintenance of genomic stability is crucial to ensure the fidelity of information contained within nucleotide sequences comprising genes and corresponding regulatory regions. The ...
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Mitochondrial DNA mutations in disease and aging
... mtDNA mutations, are also applicable to ...mtDNA mutations in mammalian aging has recently been extensively reviewed (Krishnan et ...mtDNA mutations in human aging undergo clonal expansion and cause ...
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Mitochondrial DNA mutations in disease and aging
... mtDNA mutations, are also applicable to ...mtDNA mutations in mammalian aging has recently been extensively reviewed (Krishnan et ...mtDNA mutations in human aging undergo clonal expansion and cause ...
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A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... SOS DNA damage response without a requirement for DNA ...following DNA damage and RecA* ...NTD DNA-binding and CTD protease activities while acquiring the novel function of TEV ...
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DNA damage induced by acrylamide: roe of genetic polymorphisms in DNA damage levels
... 121 relatively low toxicity leading to a slight decrease in cell viability (Fig. 4.1.A) and to a slight increase in the frequency of ACEG (Fig. 4.2.A). Several reports have shown the sensitization potential of GSH ...
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GENETIC ANALYSIS OF DNA REPLICATION IN BACTERIA: dna B MUTATIONS THAT SUPPRESS dnaC MUTATIONS AND dnaQ MUTATIONS THAT SUPPRESS dnaE MUTATIONS IN SALMONELLA TYPHIMURIUM
... Complementation analysis: T o identify the locus of the dnaE suppressors, we tested the three suppressor phage for ability to complement strains represent- ing almost all[r] ...
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