DNA damage and genome stability theory
The DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds
... DSB damage response during germination, indicative of high levels of genotoxic stress, which is induced following maturation drying and ...of genome integrity. Mechanistically ATM functions through control ...
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Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair
... DNMT, DNA methyltransferase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GPx- 1, glutathione peroxidase-1; Grx, glutaredoxin; HAT, histone acetyltransferase; HDAC, histone deacetylase; HIF-1α, hypoxia ...
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CRISPR-Cas immunity, DNA repair and genome stability
... DDSB, DNA double-strand break; D-loop, displacement-loop; FA, Fanconi anaemia; HR, homologous recombination; In/Del, insertion/deletion; MGE, mobile genetic element; MMEJ, microhomology-mediated end joining; MMR, ...
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The impact of the neisserial DNA uptake sequences on genome evolution and stability
... Modeling the effect of DUS proximity The previous analyses of core genes and diversifying genes accounted for the presence of DUSs inside genes. However, a DUS that is not intragenic but is contiguous to a gene may still ...
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Maintenance of genome stability in plants: repairing DNA double strand breaks and chromatin structure stability
... of DNA damage resulting from plant’s obligatory dependence on sunlight and the associated exposure to environmental stresses like solar UV radiation, high soil salinity, drought, chilling injury, and other ...
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Adenovirus Core Protein VII Downregulates the DNA Damage Response on the Host Genome
... in damage signaling upon protein VII expression was caused by protein VII accumulation at chromatin, we examined whether the chromatin distortion caused by protein VII correlates with downregulation of the ...
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Chromatin Regulation of DNA Damage Repair and Genome Integrity in the Central Nervous System
... helicase DNA-binding) ...the damage sites is part of the activation loop of the DDR and helps facilitate functional factor recruitment, phosphorylation of ...to DNA damage sites, with SNF2H ...
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Alpi, Arno (2004): DNA damage checkpoint pathways and the maintenance of genome stability in C. elegans. Dissertation, LMU München: Fakultät für Biologie
... and DNA damage ...to DNA damage, checkpoint pathways cause cell cycle arrest of mitotic germ cells and apoptotic death of meiotic pachytene cells (Ahmed et ...
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Longevity, Aging and DNA Damage: Investigation of the Role of 53BP1 in the Maintenance of Genomic Stability
... the DNA methylation patterns (H4K20 or H3K4 trimethylation, as well as decreased H3K9 methylation) have been showed to be related to age-associated epigenetic marks ...mentioned DNA methylations, post- ...
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The Role of Fanconi Anemia Proteins in DNA Repair, Replication Stress and Genome Stability
... increased DNA damage, recruitment of HDR factors and activation of DNA damage tolerance pathway, however none of these were any different in any of the knockout cell ...
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Adaptation to DNA damage checkpoint in senescent telomerase-negative cells promotes genome instability.
... drives genome instability in sen- ...persistent DNA damage. Upon telo- merase inactivation, the DNA damage checkpoint is ac- tivated in response to telomere replication defects or ...
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Human Papillomavirus Episome Stability Is Reduced by Aphidicolin and Controlled by DNA Damage Response Pathways
... by DNA Damage Response Pathways Terri ...the stability of human papillomavirus (HPV) in undif- ferentiated keratinocytes that maintain viral ...activate DNA damage response (DDR) ...
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CiteSeerX — HPV Episome Stability is Reduced by Aphidicolin and Controlled by DNA Damage Response Pathways
... episomes in W12E cells and aphidicolin treatment causes no additional episome 747. loss[r] ...
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Deregulation of DNA double-strand break repair in multiple myeloma: Implications for genome stability
... this genome instability remains un- ...in DNA rearrangements, we investigated the functionality of DSB repair in MM ...G2/M DNA damage checkpoint activation and hypersensitivity to IR, ...
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Delineating the Requirements for Spontaneous DNA Damage Resistance Pathways in Genome Maintenance and Viability in Saccharomyces cerevisiae
... remove damage whereas the recombination (REC) and postreplication repair (PRR) pathways bypass the damage, allowing deferred ...key damage resistance pathway in yeast and may be responsible for the ...
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DNA damage induced by acrylamide: roe of genetic polymorphisms in DNA damage levels
... 1.3. DNA Damage 1.3.1. Principles DNA damage is a relatively common event in the life of a cell and may lead to mutation, cancer and cellular or organismic death ...The genome is ...
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Review on DNA damage, repair and DNA sequencing
... corrects damage to the DNA molecules that encode its ...cause DNA damage, Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ...
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VOLUME 5 DAMAGE STABILITY
... 91 g =9.81 m/s 2 or 32.2 ft/s 2 The following data on this data set controls the calculation. For detail understanding of these data it is necessary to study the enclosed “Theory of calculation method for ...
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Epigenetic mechanisms and genome stability
... proper DNA methylation patterns and maintenance of those patterns through mitotic division is critical for cellular ...widespread DNA demethylation, especially of the paternal genome (Jaenisch and ...
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Targeting DNA damage in SCLC
... SCLC genome is highly damaged as evidenced by an exceptionally high mutation burden, with approximately ...whole genome sequencing to identify therapeutically targetable oncogenic driver mutations, George ...
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