DNA damage response pathways
Diverse Roles for Histone H2A Modifications in DNA Damage Response Pathways in Yeast
... of DNA damage that are repaired by a multiplicity of different repair ...All damage and repair occur in the context of chromatin, and histone modifications are involved in many repair ...multiple ...
11
Human Papillomavirus Episome Stability Is Reduced by Aphidicolin and Controlled by DNA Damage Response Pathways
... by DNA Damage Response Pathways Terri ...activate DNA damage response (DDR) pathways, effects of inhibitors and small interfering RNAs (siRNAs) acting within DDR ...
11
Aberrant DNA damage response pathways may predict the outcome of platinum chemotherapy in ovarian cancer.
... of DNA dam- age response (DDR) pathways, which are triggered by the detection of DNA lesions through specific sensors [ 15 ...repairing DNA damage or undergoing apoptosis, its ...
20
Rad53 and Chk1 Dependent DNA Damage Response Pathways Cooperatively Promote Fungal Pathogenesis and Modulate Antifungal Drug Susceptibility
... repair DNA damage. However, how the DNA damage response path- way is regulated for maintaining the genome integrity of fungal pathogens and how this contributes to their pathogenicity ...
22
The role and clinical significance of DNA damage response and repair pathways in primary brain tumors
... on DNA damage, the cell ’ s DNA damage repair and response (DRR) pathways may hold the key to new therapeutic ...strategies. DNA double-strand breaks (DSBs) generated by ...
6
CiteSeerX — Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways
... in DNA repair has not yet been clearly ...of DNA-repair is independent of wild-type BRCA2 ...cellular response to stalled replication forks or in the repair of replication-associated double-strand ...
8
Cell free Xenopus egg extracts for studying DNA damage response pathways
... DDR pathways in addition to the cell-free Xenopus egg extract ...of DNA repair proteins on ICL-damaged chromatin in Xenopus becomes ...of DNA damage and stressful ...
9
CiteSeerX — DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways
... Evidence has accumulated to implicate the tumor suppressor protein p53 as a major regu- lator of the G, cell cycle checkpoint in mammalian cells: cells with wild-type p53 genes exhibit t[r] ...
10
CiteSeerX — HPV Episome Stability is Reduced by Aphidicolin and Controlled by DNA Damage Response Pathways
... episomes in W12E cells and aphidicolin treatment causes no additional episome 747. loss[r] ...
40
The relationship of adenoviruses to the DNA damage response protein BLM & Understanding the modulation of DNA repair pathways by the human oncogenic virus KSHV
... 4.1 Limitations One issue throughout the duration of this project was the use of the Ad5E1HEK293 cell line as a target for infection with KSHV. Since the Ad5E1HEK293 cell line is virally transformed using the Adenovirus ...
130
Ciliogenesis and the DNA damage response: A stressful relationship.
... stress response pathways, which are in constant com- munication with the DNA damage response pathways and cell cycle ...stress/DNA damage and can regulate ...
13
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.
... the pathways of interest or which showed significant altered expression were validated by qPCR on LCM-isolated neurones from all additional cases from the CFAS Braak and Braak stage 0–II cohort, which contained ...
14
Autophagy in DNA Damage Response
... One of the best described pathways leading to autophagy is activated during starvation. In this pathway mammalian target of rapamycin (mTOR) plays a central role as a negative regulator of autophagy. mTOR complex ...
22
A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... metabolic pathways to form novel products not found in nature, or to re-engineer the regulation of these pathways for orthogonally inducible ...natural pathways to be able to activate them using ...
135
The Smc complexes in DNA damage response
... mediate DNA repair are not ...their DNA repair functions are separ- able from their major functions in sister-chromatid cohesion and chromosome ...the DNA repair func- tions of the Smc complexes are ...
11
The role of Plk4 in DNA damage pathways and entry into mitosis.
... in response to ionizing ...in response to DNA damage in a p5 3-dependent manner, the decrease in protein levels observed with UV radiation cannot be explained by a decrease in the amount of ...
80
Activation of DNA damage repair pathways by murine polyomavirus
... of DNA is required to maintain the integrity of the cellular genome. DNA damage repair (DDR) pathways protect the genome from mutation by repairing lesions from endogenous and exogenous ...
11
Role and Regulation of CIEBPa in Response to DNA Damage
... damaged DNA will enter cell cycle and mutations will accumulate at higher rate in the ...the pathways impinging upon induction of C/EBPα in response to DNA damage may be a potential ...
155
DNA-PK suppresses a p53 independent apoptotic response to DNA damage
... of DNA-PK does not rescue all modes of p53 dependent apoptosis, but is specific to DNA damage initiated ...DISCUSSION DNA-PK is not required for the canonical p53 mediated apoptotic ...
20
ATP-dependent chromatin remodeling in the DNA-damage response
... on DNA of nucleosome occupancy, the loss of which results from DNA damage and its repair, may also require ATP-dependent chromatin ...synthesized DNA as well ...alternative DNA ...
14