DNA-dependent protein kinase
Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase
... single-stranded DNA genome with inverted terminal repeats that form hairpin ...a DNA damage response (DDR) that is distinct from that seen during Ad or AAV infection ...and DNA- dependent ...
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Autoantibodies to DNA dependent protein kinase Probes for the catalytic subunit
... DNA-dependent protein kinase (DNA-PK) is an important nuclear enzyme which consists of a catalytic subunit known as DNA-PKcs and a regulatory component identified as the Ku ...
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DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease
... reduced DNA end-joining ...of DNA repair is further compromised by ...double-strand DNA (dsDNA) breaks (DSB) is non-homologous end joining (NHEJ), which requires DNA-dependent ...
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DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration
... How DNA is repaired after retrovirus integration is not well understood. DNA-dependent protein kinase (DNA-PK) is known to play a central role in the repair of double-stranded ...
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DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP
... of DNA-PKcs in mice results in radiosensitivity as well as immunodeficiency due to a failure to complete V(D)J recombination, and naturally occurring mutations in the gene have generated viable but ...
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Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 Induces the Proteasome-Dependent Degradation of the Catalytic Subunit of DNA-Dependent Protein Kinase
... on DNA-PKcs could be observed. As DNA-PKcs is present throughout the nucleus, it is possible that its degrada- tion may occur in a manner related to the localization of Vmw110 early in ...of DNA-PKcs ...
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DNA–dependent protein kinase in telomere maintenance and protection
... telomeric DNA, including double – stranded T – circles and the single – stranded C – circles, are commonly identified in cells with long telomeres through telomerase–mediated ...circular DNA types are ...
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Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage
... DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) is an enzyme encoded by PRKDC in humans ...of DNA double-strand breaks (DSBs) by accessing broken ends of DNA in ...
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Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family
... PRC). DNA dependent protein kinase (DNA-PK) –proficient and -deficient cells, the two human malignant glioma cell lines M059K and M059J, isolated and established by Allalunis-Turner et ...
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The 86 kD subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells
... and protein sequencing studies identified the tar- get antigen of 5E2 mAb as the 86-kD subunit of the Ku ...• DNA-dependent protein kinase • cell membrane • ...
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DNA-PK Deficiency in Alzheimer's Disease
... mutated protein; BER: base excision repair; DNA-PK: DNA- dependent protein kinase; DSB: double strand breaks; DSBR: Double strand break repair; HR: Homologous recombination; NER: ...
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Increased non-homologous end joining makes DNA-PK a promising target for therapeutic intervention in uveal melanoma
... pathway protein DNA-dependent protein kinase (DNA-PK) was measured by analysing the foci formation and the ligation efficiency by NHEJ determined using a plasmid-based ...
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Evaluation of Immune Responses in Mice after DNA Immunization with Putative Toxoplasma gondii Calcium-Dependent Protein Kinase 5
... It has been established that the Th1-type immune response plays a critical role in protective immunity against T. gondii (38). In this study, we have further evaluated the Th1 and/or Th2 im- mune responses in mice ...
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Toxoplasma gondii Cyclic AMP Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development
... is dependent on a TgPKAc3 ...cAMP- dependent tachyzoite maintenance was ...genomic DNA sequence spanning TgPKAc3 coding sequence (CDS) just before the stop codon followed by the 3HA tag (red box) and ...
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MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction
... cyclin-dependent kinase-like 5; ChIP: chromatin immuno-precipitation; CREB: cAMP response element-binding protein; Crh : corticotropin releasing hormone gene; Dnmt: DNA methyl-transferases; ...
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Plasmodium falciparum Calcium Dependent Protein Kinase 2 Is Critical for Male Gametocyte Exflagellation but Not Essential for Asexual Proliferation
... The kinase genes selected were either members of the CDPK family or reported to be in the calcium signaling cascade, or are activated by a second messenger other than calcium ...of DNA in the purified RNA ...
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The Role of Dbf4-Dependent Protein Kinase in DNA Polymerase ζ-Dependent Mutagenesis in Saccharomyces cerevisiae
... of protein extract was combined with 40 ml of Protein G-Sepharose 4B Fast flow beads (Sigma-Aldrich) and 25 mg of antibody in the presence of protease inhibitors [mini protease inhibitor cocktail tablets ...
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Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... mutated kinase; CiP, cyclin dependent kinase interacting protein; CDK, cyclin dependent kinase; CycD, cyclin D; DNA, deoxyribonucleic acid; eGFR, epidermal growth factor ...
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Reduced Activity of Mutant Calcium Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
... quantify kinase activity of recombinant enzymes, but these cannot differentiate between autophosphory- lation and ...the kinase activity of PfCDPK1 in terms of autophosphorylation and transphosphory- ...in ...
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Stress Granules Regulate Double Stranded RNA Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1
... contributes to the previously reported antiviral function of G3BP1 against several picornaviruses (27). This mechanism shows that SG formation, through G3BP1 and Caprin1, can induce innate immune activation. These ...
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