DNA ligase IV
DNA ligase IV syndrome; a review
... for DNA Ligase IV ...of DNA- DSB, and therefore progressive apoptosis, in haemato- poietic stem cells of LIG4 patients causing progressive immunodeficiency as lymphocytogenesis reduces over ...
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Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency: a case report and review of the literature
... a DNA ligase IV deficiency, as- sociated with SCID, with a compound heterozygous mu- tation in exon two of DNA LIG4 gene ((NM_002312) exon 2: ...(mother: ligase IV exon 2: ...
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End-Joining Repair of Double-Strand Breaks in Drosophila melanogaster Is Largely DNA Ligase IV Independent
... of DNA double-strand breaks can occur by either nonhomologous end joining or homologous ...specialized ligase, DNA ligase IV ...
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The Drosophila melanogaster DNA Ligase IV Gene Plays a Crucial Role in the Repair of Radiation-Induced DNA Double-Strand Breaks and Acts Synergistically With Rad54
... DNA Ligase IV has a crucial role in double-strand break (DSB) repair through nonhomologous end joining ...of DNA Ligase IV (Lig4) in DSB repair in a multicellular lower ...
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Successful bone marrow transplantation in a patient with DNA ligase IV deficiency and bone marrow failure
... of DNA ligase IV deficiency ...the DNA ligase IV deficiency ...R814X ligase IV mutation in vivo (hamster cell experiments) revealed an impaired interaction between ...
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Deletion of the DNA Ligase IV Gene in Candida glabrata Significantly Increases Gene-Targeting Efficiency
... The process of NHEJ is less complicated in yeasts than in mam- malian cells, where it requires many proteins. In yeast, NHEJ de- pends on the combined action of KU genes and DNA ligase IV (13, 14). ...
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Adenovirus E4 34k and E1b 55k Oncoproteins Target Host DNA Ligase IV for Proteasomal Degradation
... of DNA ligase IV. The E3 ubiquitin ligase responsible for p53 ubiquitination and deg- radation in adenovirus infection contains the cellular proteins cullin 5, elongin B and C, and Rbx1 in ...
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Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome
... of DNA DSBs during V(D)J recombination and carry translocations involving IgH and c-myc ...impaired DNA repair and genomic instability or as a secondary effect of immunodeficiency (8, ...
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ATP dependent DNA ligases
... T7 DNA ligase complexed with ATP and (b) the Chlorella virus of Paramecium bursaria (PBCV-1) DNA ligase enzyme-adenylate complex, determined by X-ray ...human DNA-repair factor Xrcc1 ...
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Serotype-Specific Inactivation of the Cellular DNA Damage Response during Adenovirus Infection
... Mre11, DNA ligase IV is degraded during infection with all of the viruses examined, probably preventing the ille- gitimate repair of viral genomes by ...endogenous DNA ligase IV ...
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Nijmegen breakage syndrome (NBS)
... radioresistant DNA synthesis, (4) biallelic hypomorphic mutations in the NBN gene, and (5) absence of full-length nibrin ...to DNA ligase IV deficiency (LIG4 syndrome) and severe combined ...
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Complete steady state rate equation for DNA ligase and its use for measuring product kinetic parameters of NAD+ dependent DNA ligase from Haemophilus influenzae
... Results: The rate equations for two possible Bi Ter kinetic mechanisms for DNA ligase, including products, are reported. The mechanisms differ according to whether the last two products, AMP and sealed ...
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Lysogenization of Escherichia coli by bacteriophage Lambda: complementary activity of the host's DNA polymerase I and ligase and bacteriophage replication proteins Q and P.
... Lysogenization ofEscherichia coli by Bacteriophage Lambda: Complementary Activity of the Host's DNA Polymerase I and Ligase and Bacteriophage Replication Proteins 0 and P USHARANJAN RAY'[r] ...
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XNA ligation using T4 DNA ligase in crowding conditions
... The above findings allow the construction of long XNA or mixed chemistry oligonucleotides, which could be useful for producing non-toxic origami structures with an enhanced stability for in-cell delivery, 8 circular ...
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Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage
... In this study, we showed that lamin A/C was a selective nuclear autophagy substrate in response to DNA dam- age. We revealed that the autophagy protein LC3 inter- acted with the nuclear lamina protein lamin A/C. ...
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A novel approach to the generation of seamless constructs for plant transformation
... foreign DNA to an organism; an issue that intragenesis and cisgenesis have been developed to counteract (reviewed in ...which DNA can be intro- duced into an organism, is limited to crossable species and ...
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Genome of Invertebrate Iridescent Virus Type 3 (Mosquito Iridescent Virus)
... IIV-3 DNA isolation, cloning, and ...genomic DNA was extracted from the pellet as previously described ...Genomic DNA was incompletely digested with TacI endonuclease (New England Biolabs, Beverly, ...
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Efficient assembly of very short oligonucleotides using T4 DNA Ligase
... a DNA Engine Dyad 2 Peltier Thermal Cycler (BIO- RAD) with parameters of 25 cycles at 96°C for 10 seconds (with an additional 2 minutes for the first cycle), 53°C for 5 seconds and 60°C for 1 minute, followed by ...
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DNA damage-induced ubiquitylation:emerging regulators enforce protective mechanisms
... We previously demonstrated that the E3 ubiquitin ligase ARIH1 is responsible for inducing a transient translation arrest upon the induction of DNA damage by cisplatin, and concluded th[r] ...
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A cost-effective method for Illumina small RNA-Seq library preparation using T4 RNA ligase 1 adenylated adapters
... T4 DNA ligase to generate adenylated adapters are partly due to the fact that it works best on double- stranded substrate, while the desired adapter is a single- stranded ...RNA ligase could be a ...
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