DNA-PK
DNA-PK Deficiency in Alzheimer's Disease
... Reduced DNA repair ability has been reported in AD ...double-strand DNA breaks (DSB) is non-homologous end joining (NHEJ) that requires DNA-dependent protein kinase (DNA-PK) ...
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Lithium mediated protection of hippocampal cells involves enhancement of DNA PK–dependent repair in mice
... mum 17 fold; Figure 8B), which suggests that the intrinsic resis- tance to IR-induced DSBs in glioma cells may be, at least in part, caused by an enhanced capacity of glioma cells for DNA-PK–depen- dent ...
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Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status.
... and DNA-PK inhibition (DNA-PKi) are actively being investigated in clinical trials with preclinical data supporting clinical translation as ...and DNA-PK with small molecule inhibitors ...
12
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells
... of DNA damage combined with temporally regu- lated NHEJ repair could result in a high number of genetic mutations in CSCs, which leads to genomic instability and fuels oncogenic ...damage DNA, may have ...
17
Hammitzsch, Ariane (2011): Einfluss der endothelialen DNA abhängigen Proteinkinase, DNA-PK, auf wachstumsfaktorabhängige angiogene Prozesse und Signaltransduktion. Dissertation, LMU München: Medizinische Fakultät
... der DNA- PKcs besitzen, schneller proliferieren ...dass DNA-PK- Knockout zu einer verlangsamten Proliferationsrate führen kann, darunter Experimente in einer humanen Adenokarzinom-Zelllinie ...und ...
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NR5A1 prevents centriole splitting by inhibiting centrosomal DNA-PK activation and β-catenin accumulation
... SF-1 restricts aberrant centriole splitting via DNA-PK We have previously shown that SF-1 depletion in Y1 cells leads to centrosome amplification [10]. The config- uration of these centrioles was here ...
9
EBNA-LP Associates with Cellular Proteins Including DNA-PK and HA95
... active DNA-PKcs, and EBNA-LP autophosphorylation is suppressed by the spe- cific DNA-PKcs inhibitor ...Wortmannin. DNA-PK phosphory- lates a number of transcription factors, in vitro, ...
7
Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing
... 1 DNA-PKcs inhibitors stimulate HDR following Cas9 induction of a ...of DNA-PK, DNA Ligase IV, and PI3K-p110 α in 293/TLR cells transfected with the indicated ...
11
Increased non-homologous end joining makes DNA-PK a promising target for therapeutic intervention in uveal melanoma
... protein DNA-dependent protein kinase (DNA-PK) was measured by analysing the foci formation and the ligation efficiency by NHEJ determined using a plasmid-based end-joining ...of DNA-PK, ...
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Physical and in silico approaches identify DNA PK in a Tax DNA damage response interactome
... and DNA-PK was selected, through our functional clustering approach, whereas other equally critical damage response proteins were ...the DNA damage-response arena equal to DNA-PK ...the ...
13
Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK
... of DNA-PK activity reduces E4orf4 recruitment to DNA damage sites but does not affect E4orf4 localization to viral replication ...of DNA-PK prevented E4orf4 from reducing ATM and ATR ...
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Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC
... in DNA-repair activity including DNA-PK, potentiating the activity of cytotoxic drug like ...of DNA-PK are less sensitive to paclitaxel-induced DNA-PK cytoplasmic ...
8
DNA-PK suppresses a p53 independent apoptotic response to DNA damage
... to DNA damage. In contrast, DNA-PK plays an anti-apoptotic role, suppressing a robust apoptotic response that is entirely p53 ...this DNA-PK regulated apoptotic ...in ...
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DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP
... of DNA-PKcs in mice results in radiosensitivity as well as immunodeficiency due to a failure to complete V(D)J recombination, and naturally occurring mutations in the gene have generated viable but ...
13
PRKDC mutations in a SCID patient with profound neurological abnormalities
... 3 DNA-PK component polypeptides. Indeed, DNA-PK protein and enzymatic activity is approximately 50-fold higher in human versus mouse cells (16, ...humans. DNA-PK avidly binds to ...
13
DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration
... whether DNA-PK was required for integration, scid and WT MEF cells were transduced at low MOI ...for DNA-PK-mediated DNA repair is apparent only in cells undergoing mitosis, we passaged ...
8
H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues
... in DNA damage response induced by different genotoxic ...around DNA double-strand breaks (DSBs) after the action of ionizing radiation or chemical agents and at stalled replication forks during replication ...
15
Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase
... AAV, DNA-PK has been previously impli- cated in the cellular response to infection by a number of other viruses ...subvert DNA-PK repair func- tions, such as the Tax oncoprotein of human ...
10
Gene expression and mutation guided synthetic lethality eradicates proliferating and quiescent leukemia cells
... and DNA-dependent protein kinase–mediated (DNA- PK–mediated) nonhomologous end-joining, whereas DNA repair pathways mediated by poly(ADP)ribose polymerase 1 (PARP1) serve as ...and ...
16
An investigation of genes involved in doubled-stranded break repair of DNA
... The DNA-dependent protein kinase (DNA-PK), comprised o f the Ku70/Ku80 (now know n as G 2 2 p l/\r c c 5 ) heterodimer and the catalytic subunit DNA PKcs (now known as Prkdc), is required for ...
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