DNA-PKcs
Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment
... Human cervical SiHa cancer cells were injected into the right hind leg of Athymic mice. Approximately 4 weeks after administration, tumor volumes of 100 mm3 were reached and mice were randomly divided into 8 groups (n = ...
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DNA Damage Sensors ATM, ATR, DNA-PKcs, and PARP-1 Are Dispensable for Human Immunodeficiency Virus Type 1 Integration
... Viral DNA integration is an essential step in the retroviral life ...stranded DNA copy of the viral genomic ...initial DNA cutting and joining steps of the integration process are mediated by the ...
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Selective DNA PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy
... of DNA- ...episodic DNA-PK inhibi- tion, as opposed to continuous or sustained inhibition, may also be beneficial in extended combination regimens, since it may avoid a potential effect on telomere ...
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Activation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage
... experimental DNA-PK in- hibitors, such as NU7026, are also under investigation for various cancers [54, ...and DNA-PKcs in DNA damage or drug resistance in EAC, the use of ...
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The Role of DNA-PKcs and Artemis in Opening Viral DNA Hairpin Termini in Various Tissues in Mice
... of DNA repair components away from sites of viral replication has been reported in the herpes simplex virus type 1 life cycle ...to DNA damage. In the past 5 years, our knowledge about the roles of ...
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TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1
... by DNA strand breaks and is also a key component involved in DNA damage recognition, repair and signal ...and DNA-PKcs cooperated within the same pathway to promote DSBs ...other ...
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<p>DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-β1/Smad Signaling Pathway</p>
... of DNA-PKcs in the migration and invasion beha- viors of cSCC cells as well as the impact of DNA-PKcs had remained ...of DNA-PKcs, we used TGF- β 1 (5 ng/mL, 48 h) to induce EMT ...
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Interaction between HIV-1 Tat and DNA-PKcs modulates HIV transcription and class switch recombination
... a DNA DSB occurs, Ku70/Ku80 is recruited to the DSB sites, which fur- ther recruits ...DNA-PKcs. DNA-PKcs is then activated by the DNA ends. In vitro, DNA-PKcs has ...
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DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis
... Because DNA-PKcs has been explored in innate DNA sensing [11, 12], studies were first performed to assess the role of this kinase in CpG-mediated fibroblast to myofibroblast ...that ...
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A DNA PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end joining
... (NHEJ) DNA repair pathway, which results in failure of functional V(D)J ...a DNA-PKcs missense mutation ...or DNA end-binding capacity of DNA-PKcs itself; rather, the presence of ...
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NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA- PKcs inhibitor
... of DNA-PKcs contributes to processing and direct ligation of broken DNA ...in DNA DSB repair, DNA-PKcs also participates in DNA DSB-induced G2/M cell cycle checkpoint ...
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Wechsler, Thomas (2005): Characterization of new interaction partners of the DNA double-strand break repair protein DNA-PKcs. Dissertation, LMU München: Fakultät für Biologie
... Second, DNA-PKcs and ATM independent pleiotropic effects might play a role as ...of DNA damage might lower their viability beyond ...of DNA-PKcs. So could be shown that in ...
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PIG3 Functions in DNA Damage Response through Regulating DNA-PKcs Homeostasis
... The DNA double-strand break (DSB) is consid- ered to be the most severe type of DNA damage in- duced by ionizing radiation, and this form of DNA damage must be repaired immediately to prevent cell ...
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KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms
... Thymidine incorporation assay (Supplementary Figure S1B) demonstrated clearly that KU-0060648 inhibited primary HCC cell proliferation. Significantly, same KU- 0060648 treatment was general safe to non-cancerous HL- 7702 ...
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Identification of DNA-PKcs as a primary resistance factor of salinomycin in osteosarcoma cells
... human DNA-PKcs were gifts from Dr. Bing Zheng [27]. The third DNA-PKcs shRNA (“-3”) was purchased from Santa Cruz Biotech (sc- ...of DNA-PKcs or Beclin-1 in the stable cells was ...
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DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway
... that DNA-PKcs is phosphorylated in mitotic phase, and the phosphor- ylated DNA-PKcs localizes at mitotic apparatus, in- cluding centrosomes, kinetochore and midbody dur- ing ...that ...
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Purification and Characterization of a Cellular Protein That Binds to the Downstream Activation Sequence of the Strict Late UL38 Promoter of Herpes Simplex Virus Type 1
... of DNA-PK in late HSV transcrip- tion, it is significant that this cellular protein is modified during HSV infection of tissue culture ...of DNA-PKcs are both greatly reduced during pro- ductive ...
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Adeno-Associated Virus Type 2 Modulates the Host DNA Damage Response Induced by Herpes Simplex Virus 1 during Coinfection
... potential DNA-PK-mediated signaling to downstream targets in coinfected cells, we assessed virus-induced phosphorylation of Chk2 and p53 in normal cells and in cells defective for either DNA-PKcs ...
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The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance
... in DNA-PKcs 3A/3A Fanca −/− ..., DNA-PKcs 3A/3A , and DNA- PKcs 3A/3A Fanca −/− embryos at ...in DNA-PKcs 3A/3A embryos compared to WT and Fanca − / − embryos, this ...
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Hammitzsch, Ariane (2011): Einfluss der endothelialen DNA abhängigen Proteinkinase, DNA-PK, auf wachstumsfaktorabhängige angiogene Prozesse und Signaltransduktion. Dissertation, LMU München: Medizinische Fakultät
... oder DNA-PKcs-Hemmung, sei es durch NU7026 oder durch siRNA, konnten die Phosphorylierung von Akt an Ser473 eindeutig erhöhen, wenn sie mit nicht be- handelten Zellen verglichen ...und ...
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