DNA repair
Involvement of the Yeast DNA Polymerase δ in DNA Repair in Vivo
... Since spontaneous mutagenesis and spontaneous recombination are efficient in pol3-13, we propose that POL3 plays an important role in DNA repair after irradiation, [r] ...
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Genomic landscape of DNA repair genes in cancer
... 193 DNA repair genes; 122 were considered directly involved in at least 1 DNA repair pathway and 71 were classified as caretaker genes indirectly involved in maintaining genomic stability ...
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DNA-Repair Capacity in Down's Syndrome
... unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical or physical ...
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Mechanism of DNA loading by the DNA repair helicase XPD
... of DNA repair ...of DNA damage detec- tion (44–46) and the possibility of CT from the 4FeS cluster to DNA (reviewed in ...the DNA adopts, is still not fully under- ...a repair ...
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DmBLM’s functions in DNA repair and recombination
... in DNA repair and recombination pathways by recognizing and cleaving specific DNA structures, including 50 and 30 flaps, bubbles, forks, and Holliday junctions ...in repair of double-strand ...
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DNA methylation reprogramming and DNA repair in the mouse zygote
... Both DNA and histone modifications in parental pronuclei of the mammalian zygote should synergistically form a specific epigenetic landscape in order to achieve a certain degree of genomic ...The DNA ...
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DNA repair in the archaea – an emerging picture
... a DNA lesion in the translocated strand as a mechanism to increase the specificity of the NER reaction (Mathieu et ...reduced DNA repair in a eukaryal system (Mathieu et ...undamaged DNA ...
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Promoter DNA Methylation of DNA Repair Genes in Cancer
... of DNA damaging events take place every day in our body but efficient DNA repair systems prevent ...of DNA damage has been linked to cancer and genetic deficiencies in specific DNA ...
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DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae
... UV-irradiated DNA has identified six essential NER factors: Rad4-Rad23, Rad14, TFIIH, Rad1- Rad10, Rad2, and replication protein A (RPA) (Guzder et ...of DNA repair factors/subcomplexes during NER ...
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Sirtuins in metabolism, DNA repair and cancer
... SIRT6, a NAD + −dependent deacetylase and ADP- ribosyltransferase, plays a critical role in numerous DNA repair pathways. The first clues to the function of SIRT6 came from SIRT6 knockout mice. These ...
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Chromatin modifiers and remodellers in DNA repair and signalling.
... a DNA repair disorder and later a checkpoint disorder, it could now be argued to be a disorder that fails to appropriately orchestrate DSB-induced chromatin changes, helping to explain its more significant ...
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Expanding the Repertoire of DNA-Mediated Signaling in DNA Repair
... of DNA repair pathways for specific types of damage, such as base excision repair (BER), which involves the excision of a single damaged base, followed by gap filling and ligation by a polymerase ...
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DNA Mediated Charge Transport in DNA Repair
... cooperative DNA CT makes possible for MutY, an extremely low copy number enzyme, a full scan of the Escherichia coli genome within the doubling time of the cell (~ 20 ...the DNA repair response to ...
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DNA repair defects and implications for immunotherapy
... of DNA repair defects with regard to tumor immunogenicity is the defect in homology-dependent recombi- nation ...of repair of DNA double-strand breaks ...
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Brc1-Mediated DNA Repair and Damage Tolerance
... Brc1 is required for tolerance of radiomimetic drugs: brc1 was originally identified as an allele-specific high-copy suppressor of the UV-C and IR hypersensitiv- ity of smc6-74. Somewhat surprisingly, brc1 D cells did ...
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DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease
... [22]. DNA-PK enzyme activity is essential for NHEJ [5]. Although DNA-PK is implicated in a variety of functions from activation of innate immunity [23] to regulation of gene expression [24], its primary ...
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Linc'ing' RNA to DNA Repair
... upon DNA damage by several DNA double-strand break (DSB) ...upon DNA damage but independent of p53 (Sharma et ...reduces DNA repair capacity by ...upon DNA damage (~3 h), at a ...
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MutL involvement in two DNA repair pathways : methyl-directed mismatch repair and very short patch repair
... a DNA substrate in the absence of ATP hydrolysis but in a reaction that requires the ATP-bound form of ...then repair events might not be properly completed due to the uncoupling and there would be an ...
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Increase in the frequency of hepadnavirus DNA integrations by oxidative DNA damage and inhibition of DNA repair.
... hepadnaviral DNA may have greater access to sites of DNA damage, which also have a longer ...chromosomal DNA is a limiting factor in hepadnaviral integration, inhibition of PARP would be expected to ...
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DNA repair and the evolution of transformation in Haemophilus influenzae.
... However, additional experiments demonstrate that this increase in survival cannot be accounted for by DNA serving as a template to recover genetic information whic[r] ...
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