DNA repair gene polymorphisms
Association of DNA repair gene polymorphisms with carcinoma prostate.
... cancer gene is believed to account for only 5–10% of prostate cancers, whereas a larger percentage of prostate cancers may be due to common polymorphisms in genes giving rise to a low penetrance risk of ...
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<p>The Impact of the Genetic Polymorphism in DNA Repair Pathways on Increased Risk of Glioblastoma Multiforme in the Arab Jordanian Population: A Case–Control Study</p>
... rs1799782G>A) DNA repair gene polymorphisms and glioblastoma multiforme (GBM) susceptibility, and survival in the Jordanian Arab ...Genomic DNA was extracted from the formalin- fi xed ...
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Investigation of DNA repair genes in patients with obsessive-compulsive disorder
... impaired DNA repair mechanisms might be rendering the dopaminergic mesocortical path- way more susceptible to these environmental ...between DNA repair gene polymorphisms and ...
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Polymorphisms in DNA repair pathway genes and <em>ABCG2</em> gene in advanced colorectal cancer: correlation with tumor characteristics and clinical outcome in oxaliplatin-based chemotherapy
... XPA gene and ABCG2 gene had significant interaction with environmental factors and prognosis, which could provide a comprehensive understanding of the implications of those SNPs in the prediction of ...
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... the DNA repair complex. XRCC1 has been reported as a candidate gene influencing the risk of ...of polymorphisms in XRCC1, rs25487 (Arg399Gln) and rs1799782 (Arg194Trp), with breast cancer risk ...
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Association between polymorphisms in DNA repair gene <em>XRCC1</em> and non-melanoma skin cancer risk: a meta-analysis
... XRCC1 polymorphisms and NMSC susceptibility, 2) studies in which NMSC was confirmed in patients by experienced pathologists, and controls were age- matched unrelated participants without any type of cancer, 3) ...
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The alterations of XRCC1 gene’s polymorphism with a different SNP is involved in breast cancer
... 14. Luo H, Li Z, Qing Y, Zhang S-H, Peng Y, Li Q, et al. Single nucleotide polymorphisms of DNA base-excision repair genes (APE1, OGG1 and XRCC1) associated with breast cancer risk in a Chinese ...
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G₂ chromosomal radiosensitivity in childhood and adolescent cancer survivors and their offspring
... of DNA repair in the protection of the genome and prevention of cancer is however appreciated (Goode et ...nucleotide polymorphisms (SNPs) make up 90% of the natural variation in the human ...
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Influences of Genetic Abnormality on the Risk of Acute Lymphoblastic Leukemia
... candidate gene association studies to the understanding of genetic susceptibility to acute lymphoblastic leukemia we conducted a systematic review from published ...The polymorphisms of genes encoding ...
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Original Article Association of single nucleotide polymorphisms of DNA repair gene and susceptibility to pancreatic cancer
... between gene polymorphisms of XRCC4 and develop- ment of pancreatic cancer was assessed by conditional logistic regression models adjusted for potential confounding factors, and the results was expressed by ...
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The Influence of Gene Polymorphisms on Tobacco and Alcohol Induced Oral Cancer Risk
... errant DNA content in ...and DNA repair enzyme polymorphisms are constitutive genotypes that may be informative for clinicians in the preventive man- agement of patients at risk, particularly ...
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Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck
... XRCC1 gene polymorphisms have been extensively studied in the association with various human cancers mostly breast, lung or head and neck ...and DNA repair ...of DNA adducts [16] and to ...
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Original Article Genetic polymorphisms of DNA repair enzymes in dilated cardiomyopathy
... polymorphisms located at POLβ codon 289 in the DCM group showed that 258 (51.4%) were homozygous for the Lys/Lys genotype, 53 (10.6%) were variant homozygous for the Met/ Met genotype, and 191 (38.0%) were ...
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Detection of Polymorphisms of DNA Repair Genes (XRCC1 and XPC) in Prostate Cancer
... tics version 20 (IBM Corp., New York, USA). Associa- tion between categorical variables was tested using Chi- square test (Χ2). When more than 20% of the cells have expected count less than 5, correction for chi-square ...
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DNA repair ERCC1 Gene Polymorphisms in Epithelial Ovarian Cancer and Relation to Platinum Resistance and Survival
... Excision repair cross-complementation group 1 (ERCC1) is a key DNA repair gene in the nucleotide exci- sion repair pathway which is activated in the repair of intra- and ...
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Role of genetic polymorphisms in dna repair genes (xrcc1, xrcc2, xrcc3, xrcc4, xrcc5, xrcc6, xrcc7) in head and neck cancer susceptibility in rural indian population: a hospital based case control study from south western maharashtra
... genotype polymorphisms of BER, DSBR, HRR genes and the elevated risk for oral cancer particularly in the users of tobacco and alcohol from the rural areas of ...of polymorphisms of the DNA ...
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<em>ERCC1</em> and <em>XRCC1</em> but not <em>XPA</em> single nucleotide polymorphisms correlate with response to chemotherapy in endometrial carcinoma
... that gene polymorphism of XRCC1 rs25487 was a risk factor for endometrial ...with DNA repair complex. XRCC1 gene was identified by its function to restore the DNA repair capacity ...
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Genome stability pathways in head and neck cancers
... on DNA repair ...Defective DNA repair generates chromosomal derangement that can cause subsequent alterations in gene expression, and is a hallmark of progression toward ...of ...
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Original Article Association of DNA repair relevant gene polymorphisms with the risk of gastric cancer in a Han Chinese population
... of DNA repair genes respon- sible for repair of DNA base damage and single- strand ...non-synonymous polymorphisms, such as Arg194Trp and Arg399Gln in the XRCC1 gene, and ...
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XPA A23G polymorphism and risk of digestive system cancers: a meta-analysis
... or DNA repair gene or NER”, “genetic polymorphism or polymorphisms or variant”, and “digestive system cancer or gastrointestinal cancers or gastric cancer or colorectal cancer or hepatocel- ...
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