DNA replication stress
DNA replication stress restricts ribosomal DNA copy number
... replication stress and tumorigenesis is well established [ 33 ...of DNA replication, such as ORC1, ORC4, ORC6, CDT1, CDT6, and CDC45, have been reported to be the cause of Meier-Gorlin ...
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CiteSeerX — DNA replication stress is a determinant of chronological lifespan in budding yeast
... to DNA replication stress downstream of deregulated nutrient signaling as an important determinant of chronological aging in budding ...reduces replication stress, as well as age- ...
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DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
... inhibits DNA polymerase alpha whereas camptothecin is a topoisomerase I ...tested DNA damaging agents is their ability to induce suf- ficient ssDNA provoking downstream DNA replication ...
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Functions of Saccharomyces cerevisiae 14-3-3 Proteins in Response to DNA Damage and to DNA Replication Stress
... /M DNA damage checkpoints, whereas only the G 2 /M checkpoint is altered by the bmh1-169 and bmh1-221 ...resuming DNA replication after transient deoxynucleotide depletion, and all display synthetic ...
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Targeting Mcl 1 enhances DNA replication stress sensitivity to cancer therapy
... stalled DNA replication forks, leading to sensitization of cells to radiation ...ing DNA resection and activation of the HR ...with DNA replication stress agents (hydroxyurea or ...
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DNA replication stress underlies renal phenotypes in CEP290 associated Joubert syndrome
... enhanced DNA damage signaling and accumulation of DNA breaks ex vivo and in ...decreased replication fork velocity, fork asymmetry, and increased levels of cyclin-dependent kinases ...rescued ...
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Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress In Vitro and In Vivo
... causes DNA replication stress? How are the expressions of ATR, Rad17, and Chk1 extinguished in postmitotic noncycling cells and stimulated in cycling cells? Will reconstitution of the ATR pathway in ...
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The Yeast PUF Protein Puf5 Has Pop2-Independent Roles in Response to DNA Replication Stress
... to DNA replication stress in cells lacking Pop2, as well as in cells mutated for two activities recruited to mRNAs by the Puf5-Pop2 interaction, the deadenylase Ccr4 and the translational repressor ...
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Establishing DNA combing to investigate DNA replication stress in vitro
... in replication dynamics between different batches of cells could lead to false ...different replication fork speeds on multiple occasions between studies (Técher et al, ...on replication fork speed ...
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CiteSeerX — SURVEY AND SUMMARY DNA replication stress, genome instability and aging
... to replication stress accelerate aging by amplifying the consequences of replication stress that develops during normal ...oxidative stress-induced and replication stress- ...
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Ploidy Dictates Repair Pathway Choice under DNA Replication Stress
... to replication stress presented by a defective minichromosome maintenance (MCM) helicase allele in ...causes replication stress in both haploid and diploid yeast, only diploid mutants exhibit ...
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Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
... possess DNA nickase activity implicated in the direct formation of DSBs and ssDNA breaks (SSBs) 19–21 that activate ATM/ATR pathways and induce G1 and G2 cell-cycle arrest 22–25 ...
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6 - DNA Replication. Overview of DNA Replication
... is DNA replication and division of the bacterial cytoplasm coordinated? ...of DNA replication. There are two general ways that DNA replication is coordinated with cell division ...
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The kinase MK2 in DNA replication upon genotoxic stress and chemotherapy
... For DNA fiber analysis, exponentially growing cells in 6-well plates with about 60% confluence were used with one well per ...of DNA fibers obtained by DNA fiber assay and schematic representation of ...
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Mismatch Repair Processing of DNA Damage Causes Replication Stress
... interrupt replication fork progression, uncoupling the DNA polymerase from the replicative helicase resulting in ssDNA stretches (Byun, Pacek et ...cellular DNA prior to MNNG treatment for 2 h and ...
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Formation of a Complex between Nucleolin and Replication Protein A after Cell Stress Prevents Initiation of DNA Replication
... of DNA synthesis at previously generated DNA repli- cation ...in DNA replication, perhaps acting as a factor that signals cell ...the DNA-damaging agent mitomycin C, suggest- ing that ...
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Spatial cross-talk between oxidative stress and DNA replication in human fibroblasts
... The nine Emerin complexes compiled in CORUM contain 59 different proteins, of which 44 were detected in our experiments. Significant changes were observed only for complexes containing lamin B1 (LMNB1). No apparent ...
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TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress
... genotoxic stress. A. Representative histograms of Ser139- phosphorylated H2AX /DNA content (propidium iodide) flow cytometry for DNA damage estimation in TSC1 +/+ and TSC1 -/- MEFs, untreated or ...
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The Role of Fanconi Anemia Proteins in DNA Repair, Replication Stress and Genome Stability
... of replication stress, but FANCI null cells were not (Chapter 2, Figure 5 A, ...increased DNA damage, recruitment of HDR factors and activation of DNA damage tolerance pathway, however none of ...
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Adenovirus type 2 DNA replication. II. Termini of DNA replication.
... labeled viral DNA, extracted from infected cells, into mature and replicating forms. Exper-[r] ...
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