DNA topoisomerase
Polyomavirus minichromosomes: associated DNA topoisomerase II and DNA ligase activities.
... When DNA topoisomerase II activity arbitrary units based on the appearance of completely unknotted bacteriophage P4 DNA molecules was computed relative to the total number of polyomaviru[r] ...
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Effects of uvsX, uvsY and DNA topoisomerase on the formation of tandem duplications of the rII gene in bacteriophage T4.
... We conclude that T 4 DNA topoisomerase muta- tions affect the frequency of rZZ diploids, but that the effect is allele-specific and that T 4 DNA topoisomer- ase therefore[r] ...
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Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II
... DNA topoisomerases have been identified as targets for drug development and some TOP I or TOP II inhibi- tors have already been used in clinic [23]. Many studies showed that the antitumor activity of ...
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Quantitative Structure Activity Relationship Study of Naphthoquinone Analogs as Possible DNA Topoisomerase Inhibitors
... deficient DNA repair. DNA topoisomerases are enzymes that alter DNA topology by causing and resealing DNA strand ...of DNA topoisomerases, i.e. Type I DNA topoisomerases (Topo I) ...
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The significance of Epstein Barr Virus (EBV) & DNA Topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, Oral Epithelial Dysplasia (OED) and Oral Squamous Cell Carcinoma (OSCC)
... Results: DNA-Topo II∝ was expressed in all examined ...OEDs. DNA-Topo II∝ expression was significantly higher in tumors of low differentiation versus tumors of moderate and high differentiation (P < ...
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MOLECULAR DOCKING STUDIES OF INDENOISOQUINOLINE DERIVATIVES WITH DNA TOPOISOMERASE I COMPLEX
... interaction with DC112 with the bond length of 2.699(Å). Kumar and Bora 1 , analysed molecular docking studies of curcumin derivatives with Top 1-DNA complex as a potential lead molecule for the development of ...
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Genetic analysis of the gyrase A-like domain of DNA topoisomerase II of Saccharomyces cerevisiae.
... used tetrad analysis to group the extragenic suppres- sor mutations. Tetrad analysis showed that seven of the 16 tos mutations fell into one linkage group, which we refer to[r] ...
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Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I.
... Biological function of TRF and TOPl gene prod- ucts: TRFl (HPRl), TRF2 and TRF4 do not encode pro- teins that are essential for proper top0 I1 transcription, translatio[r] ...
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DNA Topoisomerase 1 Facilitates the Transcription and Replication of the Ebola Virus Genome
... Phosphodiester bridge-cleaving and recombination activi- ties of TOP1. TOP1 unwinds the helical structure of DNA and RNA by cleaving the phosphodiester bridges of the nucleotide chain (26, 27). To examine whether ...
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DNA Topoisomerase I differentially modulates R loops across the human genome
... as DNA breakage [3], we speculate that R-loop suppression by Top1 plays an important role in ensuring proper gene expression and genome ...R-loop-induced DNA breakage and instability phenotypes [2, 14], the ...
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In vitro detection of apoptotic stimuli by use of the HL-60 myeloid leukemic cell line.
... a DNA topoisomerase inhibitor, as well as physiologic stimuli, including ceramide analogs and a monoclonal antibody against the Fas ...measuring DNA endonuclease activity by both enzyme-linked ...
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Vepris nobilis plant: a potential source of anticancer agents
... the topoisomerase inhibitors. Therefore, DNA topoisomerase (PDB ID:1A36) was downloaded from the protein ...the DNA topoisomerase enzyme using the chimera ...
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Tyrosyl-DNA Phosphodiesterase I a critical survival factor for neuronal development and homeostasis
... to DNA damage. Tdp1-/- and Atm-/- mice exhibit accumulation of DNA topoisomerase I-DNA covalent complexes (TOPO1-cc) explicitly in neuronal tissue during ...
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Repair of Topoisomerase-Mediated DNA Damage in Bacteriophage T4
... II topoisomerase inhibitors are used to treat both tumors and bacterial ...covalent DNA-topoisomerase cleavage complexes that ultimately cause lethal DNA ...erase-mediated DNA damage is ...
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PODOPHYLLOTOXIN AND THEIR GLYCOSIDIC DERIVATIVES
... It is a semisynthetic glucosidic cyclic acetals of podophyllotoxin. They are currently used in the chemotherapy for various types of cancer, including small cell lung cancer, testicular carcinoma, lymphoma, and Kaposi’s ...
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Coping with antibiotic resistance: contributions from genomics
... as DNA topoisomerase or RNA polymerase modifications, conferring resistance to quinolones and rifampicin, respectively; third, drug target protection, for example ribosomal methylation confer ring ...
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Genome of Invertebrate Iridescent Virus Type 3 (Mosquito Iridescent Virus)
... repetitive DNA, with DNA repeats localized in 15 apparently noncoding ...encoding DNA topoisomerase II, NAD-dependent DNA ligase, SF1 helicase, IAP, and BRO protein, are present in ...
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Synthesis of novel β-carboline derivatives with potential antimicrobial and anti helminthic activities
... alkaloids were found in several medicinal plants and displayed a variety of action on the central nervous, muscular, and cardiovascular systems. It was discovered that β-carboline derivatives might possess anti-tumor ...
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TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1
... creases DNA strand break repair rates and cell survival above that observed in Tdp1 / DT40 cells, suggesting that Tdp2 over-expression can partially complement the defect imposed by loss of ...Top1-mediated ...
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Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells
... many DNA viruses, DDR signaling can result in deleterious effects, including triggering of apoptosis and cell cycle ...many DNA viruses have evolved mechanisms to antagonize the DDR pathway in order to ...
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