DOCA-salt
Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats
... rats, DOCA/ salt treatment upregulated not only the expression of AT1-R and ACE1, but also expression of AT2-R and ACE2 in the PVN while the renin expression was de- ...of DOCA/salt-induced ...
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Protective Effect of TRPV1 against Renal Fibrosis via Inhibition of TGF-β/Smad Signaling in DOCA-Salt Hypertension
... after DOCA-salt ...to DOCA-salt treatment, indicating that TRPV1 may act as an en- dogenous renoprotective means to limit renal fibrosis via possibly interfering with TGF-β1 expression and ...
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HEMORRHAGIC SHOCK IN DOCA-SALT HYPERTENSIVE RATS: EFFECTS OF OXOTREMORINE ON BLOOD PRESSURE AND VASOPRESSIN RELEASE
... in DOCA-salt hypertension model ...to DOCA-salt hypertension (32) might explain the exaggerated responses to oxotremorine in DOCA-salt hypertension ...
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Sesamol exerts antihypertensive and renoprotective effects in a rat model of doca salt induced hypertension
... Proteinuria, which consists mainly of albuminuria, can be used as an intermediate endpoint indicating elevated intraglomerular pressure and renal damage, as well as a marker indicating treatment efficacy (de Zeeuw et al., ...
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Original Article Role of PDGFs/PDGFRs signaling pathway in myocardial fibrosis of DOCA/salt hypertensive rats
... in DOCA/salt induced hypertensive MF rats, the myofibroblasts increased marked- ly when compared with CON group, but reduced dramatically after treatment with IMA, an inhibi- tor of tyrosine ...
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Antihypertensive and Antioxidant Efficacy of Sesame Cake Extract (SCE) on Uninephrectomized DOCA-Salt Rats.
... such as sesamin, sesamolin and sesaminol, etc. Sesame cake, one of the by-products, obtained from sesame seeds after pressing for oil, has been identified for some neutraceutical characteristics including antioxidant, ...
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ANTIHYPERTENSIVE EFFICACY OF ROUWOLFIA TETRAPHYLLA – ROOT OF THE PLANT ON UNINEPHRECTOMIZED DOCA – SALT HYPERTENSIVE RATS
... body salt and water and then disordered regulation of renal functions is responsible for the altered balance of salt and water in pathophysiological states including some experimental models of hypertension ...
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Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats
... and lovastatin) [27, 28], including DOCA-salt hypertensive mice (lovastatin) [29]. We, on the other hand, found that rosuvastatin was without effect on DOCA-salt-induced hypertension in rats. ...
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“Antihypertensive Efficacy of Methanol Extracts of Pisonia aculeata L. on Uninephrectomized Doca-salt Hypertensive Rats” by S.Priya, A.Subhashini, India.
... The reduced antioxidant status might also be involved in the hepatic injury because reactive free radicals are implicated as the potential mediators of tissue injury. In this study, the activities of these enzymes were ...
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Homeopathic Medicine Rauwolfia Serpentina Ameliorate Blood Pressure and Oxidative Stress Parameters of Kidney by Modulating Expression of Antioxidant Enzymes in Deoxycorticosterone Acetate (DOCA)-Salt-Induced Hypertensive Rat Model
... in DOCA-salt-induced hypertension, and these physiological dysfunctions are involved in the development and maintenance of hypertension ...in salt-sensitive hypertension [9]. DOCA- ...
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Aliskiren Augments the Activities of Anti Oxidant Enzymes in Liver Homogenates of DOCA Salt Induced Hypertensive Rats
... group]. DOCA-Salt induced Hypertension [6] Twenty wister albino rats [group 2 & 3] were treated twice weekly with DOCA and administered subcutaneously (15 mg/kg), and 1% NaCl was added to their ...
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Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats: research paper
... Inappropriate fibroblast hyperplasia is a hallmark of fibrosis. Myofibroblasts, which are specially differentiated fibroblasts exhibiting contractile properties and expressing smooth muscle -actin, play an important ...
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Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats
... in DOCA-salt rat hearts is as an iNOS inhibitor (Nilsson, ...of DOCA-salt rats (Fujisawa et ...from DOCA-salt rats where the endothelium is ...
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Attentuation of cardiovascular remodelling in DOCA-Salt rats by the Vasopeptidase inhibitor, Omapatrilat
... with DOCA-salt hypertension was corrected by inhibition of the renin- angiotensin system with the ACE inhibitor captopril, the AT1 receptor antagonist candesartan or the aldosterone antagonist ...
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L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats
... precursor of NO, attenuates the development of structural and functional changes in hearts and blood vessels of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Uninephrectomized rats treated with ...
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INVESTIGATION OF ANTIHYPERTENSIVE MECHANISM OF CURCULIGO ORCHIOIDES IN DOCA SALT INDUCED HYPERTENSIVE RATS
... extracts of Curculigo orchioides root possessed profound antihypertensive activity. The antihypertensive effect has been found due to ACE inhibitor mechanism of Curculigo orchioides root extract because this extract ...
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L-carnitine attenuates cardiac impairment but not vascular dysfunction in DOCA-salt hypertensive rats
... the DOCA-salt rat hearts was not significantly different to that of UNX controls; heart failure is unlikely in this 4-week model, compared with 8-week DOCA-salt rats ...
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SOLUBLE GUANYLYL CYCLASE ACTIVATOR BAY 41 2272 IMPROVES VASCULAR ACTIVITY OF THORACIC AORTA ISOLATED FROM DOCA HYPERTENSIVE MALE WISTAR RATS
... (DOCA) salt dispersed in soyabean oil was administered subcutaneously at dose rate of 25mg/kg body weight twice in a week for four weeks (Chan et ...of DOCA salt administration, rats were ...
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Physalis minima Leaves Extract Induces Re-Endothelialization in Deoxycorticosterone Acetate-Salt-Induced Endothelial Dysfunction in Rats
... in DOCA-salt-induced rats may be due to oxidative ...in salt- sensitive hypertension (Seifi et ...in DOCA-salt hypertension due to reduced ...
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DC isoketal modified proteins activate T cells and promote hypertension
... DCs and similar antigen-presenting cells are essential for T cell activation by presenting antigenic peptides in MHCs and by pro- viding costimulation. In a prior study, we showed that hyperten- sion increases expression ...
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