DOCA-salt-induced rats
Physalis minima Leaves Extract Induces Re-Endothelialization in Deoxycorticosterone Acetate-Salt-Induced Endothelial Dysfunction in Rats
... in DOCA-salt-induced rats may be due to oxidative ...in salt- sensitive hypertension (Seifi et ...in DOCA-salt hypertension due to reduced ...
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L-carnitine attenuates cardiac impairment but not vascular dysfunction in DOCA-salt hypertensive rats
... aldosterone- salt hypertensive rat [7] produced similar results, following endothelin-induced increases in vascular and cardiac super- oxide production by NADPH oxidase ...
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Sesamol exerts antihypertensive and renoprotective effects in a rat model of doca salt induced hypertension
... body salt and water balance, and then disordered regulation of renal functions is liable for the altered balance of salt and water in pathophysiological states including some experimental models of ...
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Homeopathic Medicine Rauwolfia Serpentina Ameliorate Blood Pressure and Oxidative Stress Parameters of Kidney by Modulating Expression of Antioxidant Enzymes in Deoxycorticosterone Acetate (DOCA)-Salt-Induced Hypertensive Rat Model
... male rats. Administration of R. serpentina to hypertensive rats resulted in reduction of systolic and diastolic blood ...hypertensive rats were reduced in response to 30c and 6c potencies of the ...
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Antihypertensive and Antioxidant Efficacy of Sesame Cake Extract (SCE) on Uninephrectomized DOCA-Salt Rats.
... hypertensive rats. Thirty six male Wistar rats were uninephrectomized and randomly divided into six ...was induced by injecting DOCA-salt, 25 mg/kg BW subcutaneously, twice a week for ...
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Original Article Correlation between platelet-derived growth factor signaling pathway and inflammation in desoxycorticosterone-induced salt-sensitive hypertensive rats with myocardial fibrosis
... of DOCA/salt induced hypertensive rats, the inflammatory response is obvious in the myocardial intersti- tium, and it has been regarded that inflamma- tion is involved in the mineralocorticoid ...
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Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats: research paper
... The left ventricular function of the rats in all treatment groups was assessed using the Langendorff heart preparation. Terminal anaesthesia was induced via i.p. injection of pentobarbitone sodium 100 mg kg ...
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Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats
... of DOCA-salt control rats was also found to be substantially fibrosed, as evidenced by a significant increase in both interstitial and perivascular left ventricular collagen area compared with UNX ...
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HEMORRHAGIC SHOCK IN DOCA-SALT HYPERTENSIVE RATS: EFFECTS OF OXOTREMORINE ON BLOOD PRESSURE AND VASOPRESSIN RELEASE
... It has been shown that cholinomimetics improved hypotension and increased survival rate in rats subjected to severe hemorrhagic shock (10,11). The antishock effects of cholinomimetics were claimed to be mediated ...
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Original Article Role of PDGFs/PDGFRs signaling pathway in myocardial fibrosis of DOCA/salt hypertensive rats
... in DOCA/salt induced hypertensive MF rats, the myofibroblasts increased marked- ly when compared with CON group, but reduced dramatically after treatment with IMA, an inhibi- tor of tyrosine ...
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“Antihypertensive Efficacy of Methanol Extracts of Pisonia aculeata L. on Uninephrectomized Doca-salt Hypertensive Rats” by S.Priya, A.Subhashini, India.
... stress induced by reactive oxygen species (ROS) could be involved in the pathogenesis of ...7 Salt-sensitive hypertension is characterized by endothelial dysfunction associated with increase in ROS and ...
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Title: EVALUATION OF ANTIHYPERTENSIVE AND ANTIGLAUCOMA ACTIVITY OF ANDROGRAPHIS PANICULATA AND ACACIA ARABICA USING RAT ANIMAL MODEL Author: Md. Salahuddin Ansari* and Pankaj Sharma Keyword: Andrographis paniculata, Acacia Arabica, Hypertension, GlaucomaPage No: 24-28Abstract: Cardiovascular diseases are the leading cause of death globally. The medicinal value of plants lies in some chemical substances that produce a definite physiological action on the human body. Androgr aphis paniculata is used traditionally as a remedy against common cold, dysentery, cardiovascular disease and Acacia arabica is used for the treatment of asthma, cough, and ophthalmic. Hypertension induced by adding 1-2 % NaCl to drinking water for 3-6 months and injecting Deoxycorticosterone acetate-induced (10 mg/kg). Glaucoma is induced in rabbits by intraocular injection of alpha-chymotrypsin. Male rabbits weighing about 2 kg will be pretreated with 10 mg/kg i.p. indomethacin to prevent the otherwise immediate onset of inflammation and then slightly anesthetized with pentobarbital to eliminate any nystagmus. The right eye is anesthetized topically with 2% lidocaine. The interesting fact is that low dose combination of AP and AEP in highly effecting in decreasing MABP but neither High dose AP nor High dose AEP alone was achieved highest Decrease in MABP. The diabetic rats treated with the EEME (250mg/kg) showed a significant (pDownload PDF
... HT: DOCA- treated rats were developed HT as previously reported ...of DOCA was initiated, twice weekly by subcutaneous injection in a suspension of ...of DOCA–salt ...5–6 rats of ...
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SOLUBLE GUANYLYL CYCLASE ACTIVATOR BAY 41 2272 IMPROVES VASCULAR ACTIVITY OF THORACIC AORTA ISOLATED FROM DOCA HYPERTENSIVE MALE WISTAR RATS
... DOCA salt treatment significantly increases the MAP of DOCA hypertensive rats in comparison to sham ...(DOCA salt) induced hypertension by enhancing sodium intake followed ...
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Protective Effect of TRPV1 against Renal Fibrosis via Inhibition of TGF-β/Smad Signaling in DOCA-Salt Hypertension
... during salt load or salt-dependent hypertension has been established ...high salt in- take increases renal superoxide produc- tion and expression of the NAD(P)H oxi- dase subunits in sensory ...
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Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats
... Overactivity of the proinflammatory cytokines such as TNF-α and IL-1β in the PVN, a critical cardiovascular and autonomic center, has been implicated in the devel- opment and the maintenance of hypertension and heart ...
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Aliskiren Augments the Activities of Anti Oxidant Enzymes in Liver Homogenates of DOCA Salt Induced Hypertensive Rats
... tested rats of all groups for measurement of SOD levels in erythrocyte lysates using commercially available colorimetric assay kit as described above in material ...
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ANTIHYPERTENSIVE EFFICACY OF ROUWOLFIA TETRAPHYLLA – ROOT OF THE PLANT ON UNINEPHRECTOMIZED DOCA – SALT HYPERTENSIVE RATS
... in DOCA salt induced hypertension, where a significant variation in serum creatinine and urea is ...the DOCA - salt model 22 ...in DOCA-salt hypertensive rats, ...
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L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats
... 26. Koyanagi M, Egashira K, Kitamoto S, Ni W, Shimokawa H, Takeya M, Yoshimura T, and Takeshita A. Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric ...
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Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats
... in rats (Li et ...oxidant induced apoptosis (Giardino et al., 1998). In rats, aminoguanidine ameliorated the neuropathic, ocular and cardiac complications of diabetes (Miyauchi et ...ageing ...
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INVESTIGATION OF ANTIHYPERTENSIVE MECHANISM OF CURCULIGO ORCHIOIDES IN DOCA SALT INDUCED HYPERTENSIVE RATS
... in DOCA salt treated nephrectomised rats as compared to normal rats in tail-cuff with AD instrument; simultaneously derived hemodynamic parameters like mean arterial blood pressure (MABP) and ...
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