dopamine D2-receptor studies
Regulation of Akt and Wnt signalling by the dopamine D2 receptor and metabotropic glutamate receptor 2/3
... Animal studies have shown that mGluR2/3 antagonists LY341495 and LY366457 increase locomotor activity and that the increase in activity can be attenuated by treatment with antipsychotics 6, 7 ...Animal ...
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A Randomized, Prospective Comparative Study to Evaluate the Efficacy and Safety of Lurasidone and Risperidone in Treatment of Schizophrenia
... effects. Dopamine was one of the approximately 10 neurotransmitters distributed diffusely throughout the brain considered for pathophysiology of ...between dopamine function and schizophrenia came from ...
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Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects
... striatal D2/3R availability than non-obese subjects. The first two studies to demonstrate this differ- ence [7,8] were in a largely overlapping sample of obese subjects with a mean BMI of 51 kg/m 2 ...lower ...
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Chemical Scale Studies of the 5 HT₃ and D2 Dopamine Receptors
... these studies have been limited to the Xenopus oocyte heterologous expression ...many studies, there are clear benefits to expanding this technology to a mammalian expression ...study receptor ...
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Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance
... of dopamine, such as the control of motor behavior [7] or dopamine-mediated reward pro- cesses in nucleus accumbens [8], a concomitant stimula- tion of D1 and D2 receptors is required, a phenomenon ...
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THE INHIBITORY EFFECT OF ASCORBIC ACID ON APOMORPHINE-INDUCED LICKING BEHAVIOR IS MEDIATED BY DOPAMINE D2 RECEPTOR MECHANISMS IN RAT
... these studies in dopamine receptor function has been ...these studies suggest that ascorbate should be able to attenuate the stereotyped licking behavior induced by the mixed dopamine ...
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The expression profile of Dopamine D2 receptor, MGMT and VEGF in different histological subtypes of pituitary adenomas: a study of 197 cases and indications for the medical therapy
... of dopamine agonists (DAs), somatostatin analogs (SSAs) or combinations ...of dopamine D2 receptors (D2R) on tumor ...more studies demonstrated the inspiring therapeutic effect of TMZ on ...
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Effects of Ovariectomy and 17β Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight
... recent studies suggested that estradiol increased palatable food consumption ...by receptor trans- location into nucleus and transcription of hormonally regulated genes [37] ...
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Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure
... gene transfer technology to demonstrate that the deleterious effect of renal Drd2 silencing could be mini- mized by the reexpression of DRD2 in the Drd2-silenced kidney. AAV vectors have become one of the most attractive ...
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QSAR and Docking Studies on 1,2-benzisoxazole Derivatives for Antipsychotic activity against Dopamine receptor (D2)
... docking studies suggest that compound 38 interact with GLU43, THR48, GLN79, GLN147, LEU148, ASN149, ASP150, SER151, ARG178, LYS270, LEU273, THR327, GLU43, GLN79, GLN147, ASN149, ASP150, SER151 and GLU43 amino acid ...
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A thieno[2,3 d]pyrimidine scaffold is a novel negative allosteric modulator of the dopamine D2 receptor
... of dopamine binding and/or ...of dopamine efficacy, we identified analogues of 1 that displayed modulatory effects upon dopamine affinity ...both dopamine affinity and efficacy ...with ...
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Dopamine agonist inhibits vascular endothelial growth factor protein production and secretion in granulosa cells
... vitro studies [11] have suggested a role for dopamine in the regulation of the VEGF/VEGFR2 ...of dopamine are present in follicular fluid and human ovar- ian biopsies [12, 13], and dopamine ...
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Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
... twin studies (heritability estimates around 85% 3 ...twin studies may simply be due to the fact that polygenic risk scores only include com- mon genetic polymorphisms and do not assess effects of rare gene ...
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mi-Opioid/D2 dopamine receptor pharmacophore containing ligands: Synthesis and pharmacological evaluation
... was inferred, primarily involving MOR and other opioid or non-opioid receptors. The main tools in these have been numerous homo and heterobivalent ligands, designed as specific pharmacological probes. Some of the ...
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Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population
... of dopamine to neuromelanin that can enhance the formation of cyototoxic radicals contributing to neuronal degeneration ...decreased receptor binding in positron emission tomography in vivo [12] and ...
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Differential regulation of renal phospholipase C isoforms by catecholamines
... phospholipase C (PLC) activity, but whereas dopamine produces a natriuresis, NE has an antinatriuretic effect. To determine if catecholamines differentially regulate the expression of PLC isoforms, we infused ...
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Insights into Parkinson’s disease from computational models of the basal ganglia
... because dopamine depletion either changes basal ganglia control over the thalamo-cortical loop, causing it to oscillate at beta-band frequencies which are then input to the basal ganglia via cortex [S59–S61]; or ...
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... Statistical analysis of CCRCs was performed by unpaired Student’s t Test when comparing two groups, or by analysis of variance (ANOVA) followed by the Student-Newman-Keuls post hoc test in the case of three or more ...
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Interaction between the trace amine associated receptor 1 and the dopamine D2 receptor controls cocaine’s neurochemical actions
... amine-associated receptor 1 (TAAR1) plays a pivotal role in the regulation of dopamine (DA) transmission and cocaine’s ...2 receptor antagonist, L-741,626, rescued cocaine’s ability to produce ...
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Endoscopic Evaluation of Gastric Emptying and Effect of Mosapride Citrate on Gastric Emptying
... Purpose: Gastric emptying has been evaluated by scintigraphy in spite of its limitations of time consumption, cost, and danger of radioisotope. Endoscopy is a simple technique, however, its validation for gastric ...
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