Dopamine D2 Receptors
Effects of 17β Estradiol on Dopamine D2 Receptors in Thiamine Deficient Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight
... and dopamine D2 receptors ...central dopamine-D2 receptors [21] [22] and their binding receptors were described as D2/BR and D2/SUL ...and dopamine ...
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Effects of Ovariectomy and 17β Estradiol Replacement on Dopamine D2 Receptors in Female Rats: Consequences on Sucrose, Alcohol, Water Intakes and Body Weight
... of dopamine D2 receptors in the regula- tion of food intake and body ...that D2 receptor KO mice showed reduced food intake and body weight along with an increased basal energy expenditure ...
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Dopamine D2 receptors in the pathophysiology of insulin resistance
... Hoewel hoog vet voeding over het algemeen overgewicht en insuline resistentie veroorzaakt in knaagdieren, kunnen individuele dieren van eenzelfde stam toch heel verschillend reageren. Aan de hand van de gewichtstoename ...
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Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits
... mutant mouse brains, we then performed immu- nohistochemical staining of TH. Elevated TH was mainly distributed in the prefrontal cortex and striatum (Fig. 1c). Downstream of increased dopaminergic synthesis from TH is ...
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Modulatory Effects of Dopamine D2 Receptors on Spreading Depression in Rat Somatosensory Neocortex
... Evoked field excitatory postsynaptic potentials (fEP- SP) were recorded in the third layer of neocortical slices. The fEPSP was elicited by adjusting the inten- sity of stimulation to ~50% of that at which popula- tion ...
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Role of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes
... death receptors of the tumor necrosis factor receptor superfamily (Fas and TNF receptor) results in activation of the initiator cas- pase-8, which can propagate the apoptosis signal by direct cleavage of ...
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D amphetamine and antipsychotic drug effects on latent inhibition in mice lacking dopamine D2 receptors
... glutamate receptors, has also been implicated in schizophrenia (Olney et al, ...NMDA receptors are regulated by the amino-acid glycine and drugs that interact with transporters for glycine (GlyT1) may have ...
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Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice
... Background: Astrocyte-mediated neuroinflammation plays a critical role in ischemic stroke-induced secondary cerebral injury. Previous studies have suggested that the dopamine D2 receptor (DRD2) acts as a ...
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Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors
... of dopamine less readily dis- place more rapidly associating radioligands, such as chlorpro- mazine, compared to more slowly associating radioligands, such as clozapine, despite their off rates being almost ...
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THE INHIBITORY EFFECT OF ASCORBIC ACID ON APOMORPHINE-INDUCED LICKING BEHAVIOR IS MEDIATED BY DOPAMINE D2 RECEPTOR MECHANISMS IN RAT
... a dopamine D2 receptor antagonistic mechanism for ascorbate in reducing of apomorphine-induced licking ...when dopamine D2 receptors were blocked by sulpiride, ascorbate failed to ...
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Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
... with dopamine release mea- sured indirectly by displacement of radio ligands of dopamine D2 receptors in this brain area 21 ...that dopamine-dependent encoding of reward-anticipatory ...
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Hypotension and bradycardia, a serious adverse effect of piribedil, a case report and literature review
... via dopamine D2 recep- tors located in peripheral circulation and within the spinal ...the dopamine D2 receptors in the spinal ...the dopamine D2/D3 receptors ...
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Knocking Down the DRD2 by shRNA Expressing Plasmids in the Nucleus Accumbens Prevented the Disrupting Effect of Apomorphine on Prepulse Inhibition in Rat
... Traditionally, dopamine D2 receptors antagonists were prescribed for treating ...corresponding receptors in the sites rather than ventral striatum, has limited their ...on D2 ...
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Co-Administration of Curcumin and Bromocriptine Nano-liposomes for Induction of Apoptosis in Lung Cancer Cells
... the dopamine D2 receptors on pituitary epithelial cells to prevent prolactin ...stimulates dopamine receptors and has anti-mitotic and anti-tumor ...properties. D2 receptor mRNA ...
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Endoscopic Evaluation of Gastric Emptying and Effect of Mosapride Citrate on Gastric Emptying
... Mosapride, a substituted benzamide, is a 5-HT4 receptor agonist.14-16 This drug does not antagonize dopamine D2 receptors, but selectively acts on 5-HT4 receptors, thus enhancing gastroi[r] ...
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Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia
... Levodopa-induced dyskinesias (LID) are a prevalent side effect of chronic treatment with levodopa (L-DOPA) for the motor symptoms of Parkinson ’ s disease (PD). It has long been hypothesized that serotonergic neurons of ...
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The Blockade of D1/D2-Like Dopamine Receptors within the Dentate Gyrus of Hippocampus Decreased the Reinstatement of Morphine-Extinguished Conditioned Place Preference in Rats
... of receptors in the HIP mediate such ...when dopamine receptors are blocked in the HIP, and it suggests that this region by itself is not a place of rewarding but it cooperates with other parts ...
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Modulation of CaV1 3b L type calcium channels by M1 muscarinic receptors varies with CaVβ subunit expression
... Abstract Objectives: We examined whether two G protein-coupled receptors GPCRs, muscarinic M1 receptors M1Rs and dopaminergic D2 receptors D2Rs, utilize endogenously released fatt[r] ...
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Dopamine D2 receptor functional selectivity as a mechanism of atypical antipsychotic drug action
... both receptors and ligands ...of receptors on the cell surface, allowing for new types of heterodimerizations; and (4) test a much larger variety (structurally and chemically) of artificially created ...
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Neurobiological Mechanisms Linking Stress And Nicotine To Increased Alcohol Consumption
... Figure 2.6 Stress and corticosterone increase GABA release onto DA neurons ex vivo. (A) Spontaneous inhibitory postsynaptic currents (sIPSCs) onto VTA DA neurons were recorded using the whole-cell patch-clamp ...
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