Dorsal closure
Drosophila Dok is required for embryonic dorsal closure
... Embryonic dorsal closure (DC), which represents such an epithelial morphogenetic event in Drosophila, begins at stage 11 when, following germband retraction, a dorsal hole appears in the epidermis ...
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The Fes/Fer non receptor tyrosine kinase cooperates with Src42A to regulate dorsal closure in Drosophila
... Generation of loss-of-function dfer mutants Expression of DFer in leading edge cells suggests that it might play a role in dorsal closure. In the GAL4 insertion line MZ465 (Hidalgo and Brand, 1997), a ...
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Spatial, temporal and molecular hierarchies in the link between death, delamination and dorsal closure
... of dorsal closure and the influence on cell behaviour, we imaged embryos of all genotypes from comparable stages (depicted in ...of closure and determined: (1) numbers of delaminations, (2) time to ...
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Cytoskeletal dynamics and supracellular organisation of cell shape fluctuations during dorsal closure
... Drosophila dorsal closure (DC) provide an ideal system with which to understand contractile epithelia, both in terms of the cellular mechanisms and how tissue behaviour emerges from the activity of ...
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PVF1/PVR signaling and apoptosis promotes the rotation and dorsal closure of the Drosophila male terminalia
... ABSTRACT The Drosophila adult male terminalia originate from the genital disc. During the pupal stages, the external parts of terminalia evert from two ventral stalks; the everted left and right dorsal halves fuse ...
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Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure
... Dorsal closure is a paradigm epithelial fusion episode that occurs late in Drosophila embryogenesis and leads to sealing of a midline hole by bonding of two opposing epithelial ...
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The AF-6 Homolog Canoe Acts as a Rap1 Effector During Dorsal Closure of the Drosophila Embryo
... R ap1 belongs to the Ras superfamily of small GTP- of Rap1 are emerging from studies in Drosophila. Loss- ases, which cycle between an inactive GDP-bound of-function (lof) mutations in Drosophila Rap1 cause and an active ...
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Armadillo/β catenin dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila
... The polarisation of the DME cells occurs in the plane of the epithelium and can be seen as a manifestation of the phenomenon of planar cell polarity (PCP). As a specific branch of Wg signalling has been implicated in PCP ...
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Par3/Bazooka and phosphoinositides regulate actin protrusion formation during Drosophila dorsal closure and wound healing
... function. Closure of epithelial wounds is primarily driven by the cells bordering the wound, which undergo morphological changes following wounding, including the assembly of dynamic actin protrusions on the edge ...
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The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation
... 2004). Dorsal closure (DC) of the Drosophila embryo is used in the study of developmental epithelial fusions and wound ...the closure of epithelia, the first row of cells at the edge of the advancing ...
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Smurf Downregulates Echinoid in the Amnioserosa To Regulate Drosophila Dorsal Closure
... drive dorsal closure (Ducuing and Vincent 2016; Pasakarnis et ...the dorsal midline to complete dorsal ...of dorsal closure (Laplante and Nilson ...
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Mechanical control of global cell behaviour during dorsal closure in Drosophila
... ASGal4/UAS-p35 embryo (M-O; see Movie 3 in the supplementary material), carrying the ubiECadGFP transgene at 20, 80 and 140 minutes after the start of dorsal closure (DC), defined as the onset of ...
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Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure
... on dorsal closure, the movement of lateral ectodermal cells towards the dorsal midline thereby sealing the hole left following germ band ...During dorsal closure the cardioblasts appear ...
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Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure
... an increase in embryonic lethality and penetrance of morphogenetic defects (supplementary material Table S5). Of unhatched rpk/Df embryos (n=103 unhatched, 34.3% total observed), 78% fail to develop cuticle and were not ...
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Integration of actomyosin contractility with cell cell adhesion during dorsal closure
... Since in SqhA21 and SqhE21 embryos the contraction of AS cells is affected, we analysed if this perturbed cell behaviour also affected tissue closure. The contractile force of the AS is the major force driving ...
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Emergent material properties of developing epithelial tissues
... over dorsal closure ...as dorsal closure evolves, which sug- gests that the lag between the two signals decreases over ...over dorsal closure evolutions, which suggests a higher ...
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Parallels between tissue repair and embryo morphogenesis
... There are a number of lessons for better wound healing that can be learned from the embryo. Undoubtedly, there are many parallels between those tissue movements that shape embryos during development and those that are ...
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Halle_Ronk._Senior_Thesis._Spring_2018.pdf
... mutants can be generated by crossing the strong Mat-Ga14 (II,III) maternal driver with UAS.cno RNAi Valium 22 (II). These very strong canoe knockdown mutants will be appropriate for examining how near-complete loss of ...
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Drosophila embryos as model systems for monitoring bacterial infection in real time
... C Stills from a timelapse movie see Video S7 of an embryo injected with Mcf1 show that the presence of the toxin has no effect on dorsal closure which proceeds at the same speed as obser[r] ...
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Coordinated cell shape changes control epithelial movement in zebrafish and Drosophila
... Drosophila dorsal closure (reviewed by Harden, 2002; Jacinto et ...2002b). Dorsal closure is one of the last morphogenetic movements during Drosophila embryogenesis and occurs as the opposing ...
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