Dorsal root ganglia
Friedreich ataxia: metal dysmetabolism in dorsal root ganglia
... Dorsal root ganglia (DRG) are a primary target of Friedreich ataxia (FA) [1,2]. The reason for this vulner- ability in comparison with other neural tissues is un- known. The mutation in the vast ...
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Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia
... the dorsal root ...spinal dorsal horn; however, it remains unknown whether the expression of these receptors is altered in the dorsal root ganglion after nerve ...(L)4/L5 dorsal ...
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A SCN9A gene encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia
... Results: The frequency of the rs6754031 polymorphism was significantly different in both groups (P = 0.036) mostly due to an absence of the GG genotype in controls. Interestingly; patients with this rs6754031 GG genotype ...
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Upregulation of CXCL10 in Human Dorsal Root Ganglia during Experimental and Natural Varicella-Zoster Virus Infection
... human ganglia during herpes ...two dorsal root ganglia (DRG) were obtained, one of which innervated the site of the lumbar ...VZV-infected ganglia treated with ...(B) ganglia. ...
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Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation
... Introduction: Dorsal root ganglia (DRG) are highly vulnerable to frataxin deficiency in Friedreich ataxia (FA), an autosomal recessive disease due to pathogenic homozygous guanine-adenine-adenine ...
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TDP43 pathology in the brain, spinal cord, and dorsal root ganglia of a patient with FOSMN
... Postmortem examination revealed TAR DNA-binding protein (TDP) 43 proteinopathy with widespread distribution. TDP43 pathology was seen in the neurons and glial cells and was most pronounced in the subthalamic nucleus ...
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Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons
... Anatomical studies have revealed that, unlike the ol- factory bulb and the amygdala, the lower brainstem nu- clei, including the medullary reticular formation, locus ceruleus, and raphe nucleus, are directly connected to ...
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Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury
... mouse dorsal root ganglia (DRG) following spared nerve injury ...the dorsal horn, resulting in its dissociation from the genome, thereby alleviating repression of genes linked to pain ...
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Increase of TRPV1 Immunoreactivity in Dorsal Root Ganglia Neurons Innervating the Femur in a Rat Model of Osteoporosis
... in dorsal root ganglia (DRG) neurons labeled with neurotracer [Fluoro- Gold (FG)] innervating the femurs of Sprague Dawley rats were examined in control, sham, and ovariectomized (OVX) ...
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Original Article Decreased calcitonin gene-related peptide expression in the dorsal root ganglia of TNF-deficient mice in a monoiodoacetate-induced knee osteoarthritis model
... Abstract: Background: The detailed mechanisms of knee osteoarthritis (OA) pain have not been clarified, but in- volvement of inflammatory cytokines such as tumor necrosis factor-alpha (TNF) has been suggested. The ...
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Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study
... Sundt D, Gamper N, Jaffe DB. Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study. J Neurophysiol 114: 3140 –3153, 2015. First published Sep- tember ...
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An immunocytochemical, morphological and morphometric study of the axotomy-induced degeneration in dorsal root ganglia and the effect of administered neurotrophic factors
... the ganglia with myelinating and unmyelinating Schwann cells associated with axons (for review see Lieberman, ...Ultrastructurally, dorsal root ganglia are seen to consist o f these various ...
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The discovery of stannin in rat dorsal root ganglia using an integrated proteohistological approach
... In an effort to discover novel targets, we have used this unique integration of functional proteomics, in situ hybridization, and histo- chemical techniques to study a well-character- ized model of inflammation and ...
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Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling
... larval dorsal root ganglia ...of ganglia-containing cells that express the Tg(sox10:nlsEos) transgene (green) and neurons labeled with Elavl ...
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Porphyrin heme biosynthesis in organotypic cultures of mouse dorsal root ganglia Effects of heme and lead on porphyrin synthesis and peripheral myelin
... mouse dorsal root ganglia may be due to toxic effects of the metal on the heme biosynthetic pathway in myelinating cells and that exogenous heme may counteract this toxic effect of ...
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The Lyme disease spirochete Borrelia burgdorferi induces inflammation and apoptosis in cells from dorsal root ganglia
... of dorsal root ganglia cells from normal adult rhesus macaques and characterized the cells phenotypic- ...the dorsal roots, we investigated whether ...
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Collagen as Adherent Substratum and Inducer of Dorsal Root Ganglia Outgrowth
... substratum. Dorsal root ganglia (DRG) from a 8-day chick embryo were cultured in a 96-multiwell plate coated with collagen and different concentration of NGF 0, 10, 25, 50, 100, 200 and 300 ...ng/ml. ...
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The role of the transcription factor Rbpj in the development of dorsal root ganglia
... The function of Notch signaling in DRG development, as revealed by in vitro studies and in vivo chick studies, is consistent with its two fundamental roles in the devel- opment of the nervous system: maintaining ...
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Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitrostudy
... the dorsal horn, we speculate that enhanced BDNF would also have chance to activate local trkB receptors in DRG, leading to trkB dimeriza- tion and auto-phosphorylation, which would ultimately trigger pre-synaptic ...
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Demyelination and cytopathic effects in cultures of mammalian dorsal root ganglia infected with encephalomyocarditis virus.
... SHAHAR, AND RACHEL MONZAIN Israel Institute for Biological Research, Ness-Ziona, Israel Replication of encephalomyocarditis virus and its cytopathic effects were studied in myelinated cu[r] ...
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