Dorzolamide 2%
Brinzolamide 1%/timolol versus dorzolamide 2%/timolol in the treatment of open-angle glaucoma or ocular hypertension: prospective randomized patient-preference study
... Purpose: The objective of this study was to assess preference for fixed-combination brinzolamide 1%/timolol 0.5% (BTFC) versus fixed-combination dorzolamide 2%/timolol 0.5% [r] ...
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Comparative Evaluation of the Efficacy of the Bimatoprost 0 03%, Brimonidine 0 2%, Brinzolamide 1%, Dorzolamide 2%, and Travoprost 0 004%/Timolol 0 5% Fixed Combinations in Patients Affected by Open Angle Glaucoma
... 1%, dorzolamide 2%, and travoprost ...43.57%, dorzolamide/timolol ...Brimonidine, dorzolamide, bimatoprost and travoprost/timolol fixed combinations statistically significantly reduced the ...
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Intraocular pressure reduction of fixed combination timolol maleate 0.5% and dorzolamide 2% (Cosopt) administered three times a day
... tion dorzolamide and timolol in adult patients with elevated intraocular pressure: an eight week, randomized, open-label, parallel-group, mul- ticenter study in Latin ...
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Comparison of timolol 0.5% + brimonidine 0.2% + dorzolamide 2% versus timolol 0.5% + brimonidine 0.2% in a Mexican population with primary open-angle glaucoma or ocular hypertension
... The primary efficacy endpoint was the IOP-lowering effect after 3 months of treatment. Patients were assessed for eligibility at a screening visit 6 weeks before baseline when a medical and ocular history was taken, IOP ...
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Clinical utility and differential effects of prostaglandin analogs in the management of raised intraocular pressure and ocular hypertension
... Abstract: Prostaglandin analogs (PGA) are powerful topical ocular hypotensive agents available for the treatment of elevated intraocular pressure (IOP). Latanoprost 0.005% and travoprost 0.004% are prodrugs and analogs ...
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Brinzolamide-timolol suspension: acceptability and side effect profile
... 13. Vold SD, Evans RM, Stewart RH, Walters T, Mallick S. A one-week comfort study of BID-dosed brinzolamide 1%/timolol 0.5% ophthalmic suspension fixed combination compared to BID-dosed dorzolamide 2%/ ...
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Update and optimal use of a brinzolamide-timolol fixed combination in open-angle glaucoma and ocular hypertension
... A one-year, double-masked, prospective, randomized, multicenter, active-controlled, parallel-group clinical trial compared the fixed combinations of brinzolamide 1%/ timolol 0.5% and dorzolamide 2%/timolol ...
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Role of fixed-combination brinzolamide 1%/timolol 0.5% in the treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension
... Abstract: Brinzolamide 1%/timolol 0.5% is a new fixed-combination for the treatment of open-angle glaucoma or ocular hypertension. Brinzolamide/timolol has a favorable safety profile, with an incidence of ocular burning ...
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Efficacy and tolerability of the fixed combination of brinzolamide 1% and timolol 0.5% in daily practice
... A predefined subgroup analysis based on previous and new therapies was conducted in which change in IOP from the baseline visit to the Week 4–6 visit was calculated for patients who had been taking one of the following ...
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Efficacy and safety of travoprost/timolol vs dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertension
... of dorzolamide 2%/timolol ...the 2 follow-up visits (Week 2 and Week ...least 2 IOP measurements were taken. If the 2 measurements for the same eye differed by 4 mmHg or less, ...
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Efficacy, safety and tolerability of combination therapy with timolol and dorzolamide in glaucoma and ocular hypertension
... receive dorzolamide 2%/timolol ...at 2 and 4 hours after drug administration; only the IOP values from day 36 were ...the 2 treat- ment groups in either ...
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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF DORZOLAMIDE HCl IN BULK AND PHARMACEUTICAL DOSAGE FORMS
... Repaglinide is widely used as a hypoglycemic drug for the treatment of chronic type 2 diabetes mellitus. The objective of the present study was to improve the bioavailability of repaglinide by nasal delivery using ...
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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF DORZOLAMIDE HCl IN BULK AND PHARMACEUTICAL DOSAGE FORMS
... Instruments and reagents: A Shimadzu-1800 UV/Vis double beam Spectrophotometer with 1 cm matched quartz cells was used for all spectral measurements Distilled water was used as solvent for dilution. Authentic drug sample ...
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Effect of 3 years of treatment with a dorzolamide/timolol (1%/0.5%) combination on intraocular pressure
... than 2 mmHg in two consecutive visits compared with the average of the last two measurements, IOP control was considered to be ...= 2) were switched to DTFC, while nine ...
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Safety and efficacy of switching from dorzolamide 1.0%/timolol maleate 0.5% eye drops to brinzolamide 1.0%/timolol maleate 0.5% eye drops
... 301 patients with primary open-angle glaucoma or ocular hyper- tension with timolol for 4 weeks. Patients were then divided into two groups, with one group switched to BTFC drops (150 cases) and the other group ...
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Topical dorzolamide for macular edema in the early phase after vitrectomy and epiretinal membrane removal
... and 2 weeks, 1 month, and 3 months after surgery was ...at 2 weeks and 3 months after surgery was ...at 2 weeks after surgery were found between the treatment group ...at 2 weeks, 1 month, and ...
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Rp-Hplc Method Development And Validation For Estimation Of Dorzolamide Hydrochloride (Carbonic Anhydrase Inhibitor) In Bulk Dosage Form
... for Dorzolamide hydrochloride was developed and validated by Isocratic ...of Dorzolamide Hydrochloride in commercial samples. The λ max of Dorzolamide Hydrochloride in water was found to be ...of ...
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The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study
... Methods: Thirty-four eyes of 34 clinically stable POAG patients receiving treatment with timolol and dorzolamide eye drops were enrolled in this prospective, comparative, randomized interventional pilot study. ...
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DESIGN AND OPTIMIZATION OF CONTROLLED RELEASE OCULAR INSERTS OF DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE FOR TREATMENT OF GLAUCOMA
... METHODS: Dorzolamide Hydrochloride and Timolol maleate were obtained as gift samples from Wockhard ...of dorzolamide HCl and timolol maleate were measured with a UV-Vis spectro- photometer (UV 1700, ...
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2′ (2 Fluorobenzylidene) 2 hydroxybenzohydrazide
... The title molecule (Fig. 1) is essentially planar, with an r.m.s. deviation of 0.08 AÊ. As a result of conjugation, the C O distance [1.230 (2) AÊ] is longer than the normal value of 1.20 AÊ, and the C1ÐN1 bond ...
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