double-blind placebo-controlled challenge
Development and validation of a standardized double-blind, placebo-controlled food challenge matrix for raw hazelnuts
... The DBPCFC series were freshly prepared the day itself (± 2–4 h prior start of the challenge) (Table 2). For the verum vehicles first, a dilution series was prepared with suspended hazelnuts in lukewarm water (± ...
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The diagnostic value of component-resolved diagnostics in peanut allergy in children attending a Regional Paediatric Allergology Clinic
... subsequent double-blind, placebo-controlled food challenge (DBPCFC) is considered to be the gold standard for diagnosing food allergy ...
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Diuretic versus placebo in normotensive acute pulmonary embolism with right ventricular enlargement and injury: a double-blind randomised placebo controlled study. Protocol of the DiPER study
... Regarding symptomatic treatment, the challenge is to overcome RV failure. Indeed, RV plays a key role in main- taining haemodynamic stability during PE. RV dysfunc- tion is present in 15 – 40% of patients during ...
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Randomized, double-blind, placebo-controlled and active-controlled study to assess the relative abuse potential of oxycodone HCl-niacin tablets compared with oxycodone alone in nondependent, recreational opioid users
... Sixty-four participants entered the naloxone challenge and drug discrimination test. Of these, 49 (77%) entered the treatment phase, and 15 participants discontinued for the following reasons: drug discrimination ...
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Cow’s milk allergy in Dutch children: an epigenetic pilot survey
... measurements were performed by questionnaires until 2.5 years of age. All children with symptoms sugges- tive of CMA underwent, among others, serum specific IgE (sIgE) measurement (Phadia Diagnostics, Uppsala, Sweden) ...
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Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab
... a double-blind placebo-controlled oral food challenge (DBPCFC) as described below; and (5) had signed informed ...poorly controlled asthma (defined as FEV1 below 80 percent of ...
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A randomized, double-blind, placebo-controlled study.pdf
... milk challenge result at baseline defined as reacting with clear signs, symptoms, or both to a cumulative dose of ...line double-blind, placebo-controlled food challenge (DBPCFC) ...
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Compensatory changes in energy balance during dapagliflozin treatment in type 2 diabetes mellitus: a randomised double-blind, placebo-controlled, cross-over trial (ENERGIZE)—study protocol
... insulin resistance, which leads to the development of microvascular and macrovascular complications. It is a major global public health challenge; the prevalence is expected to rise to 592 million by 2035. 1 A ...
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Standardization of double blind placebo controlled food challenge with soy within a multicentre trial
... Here we present the hitherto largest group of adults with combined sensitization to birch allergen Bet v 1 and to its soy homologue Gly m 4 being investigated by DBPCFC. In this multicentre trial, 82 subjects (59.4%) had ...
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A Brief Review on Food Allergy
... of double-blind placebo-controlled oral food challenge, the “gold standard” for diagnosis of food allergy, shows that questionnaire-based studies overestimate the prevalence of food ...
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<p>Buprenorphine/samidorphan combination for the adjunctive treatment of major depressive disorder: results of a phase III clinical trial (FORWARD-3)</p>
... FORWARD-3 (ClinicalTrials.gov NCT02158546) was a phase III, multicenter, randomized, placebo-controlled study conducted at 58 study sites: 49 in the US and nine in Bulgaria. The study enrolled male and ...
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Drug adherence to biologic DMARDS with a special emphasis on the benefits of subcutaneous abatacept
... 2 study and were randomized to receive either abatacept or placebo for 6 months. The primary end point was the develop- ment of RA at 12 months. Fewer patients in the abatacept group (12/26 or 46%) progressed to ...
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Biologics in the treatment of psoriasis and emerging new therapies in the pipeline
... many patients in the treated groups relapsed during the 2-week treatment-free follow-up period and only patients in the highest dose group still showed sustained clinical improvement. The treatment was well tolerated, ...
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Use of oral midazolam as a premedication in patients undergoing diagnostic UGI Endoscopy: A double blind placebo controlled randomized trial
... Demographic data including age, sex, body weight, education level, baseline vital signs and anxiety score (10 cm visual analogue scale: 0, no anxiety to 10, extreme anxiety) were collected. Patients were randomly ...
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Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex
... Everolimus is approved for the treatment of adults with renal angiomyolipoma and TSC not requiring immediate surgery, and of adults and children $3 years of age with SEGA associ- ated with TSC who require therapeutic ...
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Efficacy of N-Acetylcysteine Augmentation on Obsessive Compulsive Disorder: A Multicenter Randomized Double Blind Placebo Controlled Clinical Trial
... The Ethics Committee of Shiraz University of Medical Sciences approved this study and it was performed according to the Declaration of Helsinki ¬and its later revisions. The patients/caregivers provided written informed ...
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Targeted treatment of advanced ovarian cancer: spotlight on rucaparib
... with placebo during initiation and maintenance therapy; chemotherapy with bevacizumab during initiation but placebo during maintenance; and finally, chemotherapy with bevacizumab during initiation and ...
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Biological targets in the treatment of rheumatoid arthritis: a comprehensive review of current and in-development biological disease modifying anti-rheumatic drugs
... a double blind, parallel-group, global study, 686 subjects were randomized to etanercept (25 mg twice weekly), MTX (up to 20 mg/week) or a combination of etanercept and ...
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Randomized trial of daily high-dose vitamin D3 in patients with RRMS receiving subcutaneous interferon β-1a
... and, therefore, support the biological effect of vitamin D on the disease process of MS suggested by earlier studies and suggest a potential benefit over a longer outcome period than the one covered by SOLAR. A prospective ...
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Zinc for Infection Prevention in Sickle Cell Anemia (ZIPS): study protocol for a randomized placebo controlled trial in Ugandan children with sickle cell anemia
... Block randomization will be used for this study. Children will be randomized (in blocks of eight) into treatment groups by order of entry in the study, based on a pre-determined blinded randomization list created and ...
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