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down regulation

Down regulation of cell surface CXCR4 by HIV 1

Down regulation of cell surface CXCR4 by HIV 1

... extensive down-regulation of cell surface CXCR4 expression, which correlated with the increase in HIV-1 protein ...detected. Down-regulation of the CXCR4 coreceptor during productive infection ...

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Original Article Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer

Original Article Down-regulation of long non-coding RNA LET is associated with poor prognosis in gastric cancer

... Although down-regulation of lncRNA LET in several cancers has been studied, its role in gastric cancer remains ...markedly down-regulated in tumor tissues compared with adjacent non- tumor tissues, ...

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Down-Regulation of Laminin-5 in Breast Carcinoma Cells

Down-Regulation of Laminin-5 in Breast Carcinoma Cells

... (B) Northern blotting of ln-5 mRNAs in breast luminal epithelial and myoepithelial cells im- munomagnetically sorted from primary cultures of normal breast tissue.. Normal cultured 76N c[r] ...

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Antisense RNA based down-regulation of RNaseE in E.coli

Antisense RNA based down-regulation of RNaseE in E.coli

... Feedback regulation of RNaseE is mediated in cis by the 361nt rne 5'-untrans- lated region (UTR), which could confer this property onto heterologous transcripts to which it was fused ...feedback regulation ...

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The interaction of CD4 with the endocytic pathway during down-regulation

The interaction of CD4 with the endocytic pathway during down-regulation

... The data presented above i n d i c a t e that CD4 is delivered to a perin u clear com partm ent that can be costained with antibodies to the C I-M P R during phorbol ester-induced dow n-regulation (Figure 32, E ...

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Non-uremic calciphylaxis in alcoholic hepatitis

Non-uremic calciphylaxis in alcoholic hepatitis

... Uremic toxins such as calcium, phosphorus, PTH, and vitamin D along with ROS contribute to VSMC differentiation into osteoid-like cells. Phosphate absorption into these cells results in an osteogenic switch. On the other ...

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Original Article Increased HDAC3 and decreased miRNA-130a expression in PBMCs through recruitment HDAC3 in patients with spinal cord injuries

Original Article Increased HDAC3 and decreased miRNA-130a expression in PBMCs through recruitment HDAC3 in patients with spinal cord injuries

... Recent studies have shown that PBMCs nucle- ar extracts decreased the levels of HAT while HDAC tended to increase in SCI patients [12]. To consistent with this, our result also showed increased HDAC3 mRNA (superior to 3 ...

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Integrative Analysis of Global Gene Expression Identifies Opposite Patterns of Reactive Astrogliosis in Aged Human Prefrontal Cortex

Integrative Analysis of Global Gene Expression Identifies Opposite Patterns of Reactive Astrogliosis in Aged Human Prefrontal Cortex

... number of neurons or a down-regulation in the expression of genes related to a specific aging. 356[r] ...

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Abnormal parathyroid hormone stimulation of 25 hydroxyvitamin D 1 alpha hydroxylase activity in the hypophosphatemic mouse  Evidence for a generalized defect of vitamin D metabolism

Abnormal parathyroid hormone stimulation of 25 hydroxyvitamin D 1 alpha hydroxylase activity in the hypophosphatemic mouse Evidence for a generalized defect of vitamin D metabolism

... This loss of responsiveness may be a function of several mechanisms, including down regulation of the PTH receptor droxylase regulation in vitamin D-deficient, calcium-deficient and prod[r] ...

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Vehicle to grid aggregator to support power grid and reduce electric vehicle charging cost

Vehicle to grid aggregator to support power grid and reduce electric vehicle charging cost

... voltage regulation [4], spinning reserve [5], load peak shifting [6] and frequency regulation ...frequency regulation has received significant attention from the academic community ...up/down ...

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Original Article Downregulation of microRNA-519 promotes angiogenesis induced by cerebral ischemia via upregulating HIF-1α expression

Original Article Downregulation of microRNA-519 promotes angiogenesis induced by cerebral ischemia via upregulating HIF-1α expression

... significant down-exp- ression ...the regulation of angiogenesis in response to ischemic injury to the brain, and further demonstrated that down-regulation of miR-519 can up regulate HIF-1α, ...

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X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells

X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells

... was down-regulated sig- nificantly both in LK and SPC ...that down-regulation of DNMT1, DNMT3b and MeCP2 closely correlates with de-methylation of the Dab2 gene promoter, as well as the ...

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Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition

<p>Paeoniflorin Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension by Inhibiting Endothelial-to-Mesenchymal Transition</p>

... induced down-regulation of endothelial marker (vascular endothelial cadherin) and up- regulation of mesenchymal markers ( fi bronectin and vimentin) in lung, suggesting that PF could inhibit SuHx – ...

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Distinct Stress Responses of Two Functional Laccases in Cryptococcus neoformans Are Revealed in the Absence of the Thiol-Specific Antioxidant Tsa1

Distinct Stress Responses of Two Functional Laccases in Cryptococcus neoformans Are Revealed in the Absence of the Thiol-Specific Antioxidant Tsa1

... distinct regulation of each gene in response to stress in the absence of the TSA1 ...in regulation results in the induced expression of LAC2 in the absence of Tsa1 during nitrosative stress, sug- gesting ...

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Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo

Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo

... interference with Usp9X levels, suggesting that Usp9X is upstream of Bag3 and that it is implicated in the regulation of its expression. Next, we examined how GX15-070 regulates the expression levels of both Usp9X ...

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Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species

Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species

... metabolic regulation among these studies. We observed a down- regulation of beta-oxidation and an up-regulation of gluco- genic amino acid utilization in the liver ...were down- ...

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CD133 promotes gallbladder carcinoma cell migration through activating Akt phosphorylation

CD133 promotes gallbladder carcinoma cell migration through activating Akt phosphorylation

... Next, we examined the contribution of Akt signaling pathway in CD133 promoting GBC cell migration. To examine this point, myr-Akt, a constitutively active form of Akt, was introduced to GBC cells infected with CD133 ...

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Original Article Interaction between fatty acid synthase and human epidermal growth receptor 2 (HER2) in osteosarcoma cells

Original Article Interaction between fatty acid synthase and human epidermal growth receptor 2 (HER2) in osteosarcoma cells

... Abstract: Elevated expression of fatty acid synthase (FASN) and human epidermal growth factor receptor-2 (HER2) are observed in human osteosarcoma (OS). The aim in this study is to investigate a possible connection ...

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Synergistic interaction between C5a and NOD2 signaling in the regulation of chemokine expression in RAW 264 7 macrophages

Synergistic interaction between C5a and NOD2 signaling in the regulation of chemokine expression in RAW 264 7 macrophages

... The innate immune response is a complex process in- volving multiple pathogen-recognition receptors, in- cluding toll-like receptors (TLRs) and nucleotide- binding oligomerization domain (NOD)-like receptors. Complement ...

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