Downregulation and upregulation
Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways
... andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by.. downregulation of Pi3K/aKT and upregulation of p38 MaPK pathways.[r] ...
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Integrative Modeling of Oxidative Stress and C1 Metabolism Reveals Upregulation of Formaldehyde and Downregulation of Glutathione
... computational systems biology platform that allows for modular integration of molecular pathway models, by coupling the in silico model of oxidative stress with the in silico model of C1 metabol- ism, and 2) derivation ...
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Original Article Downregulation of microRNA-375, combined with upregulation of its target gene Janus kinase 2, predicts unfavorable prognosis in patients with gastric cancer
... or downregulation of JAK2 by RNAi dramatically inhibited the proliferation of malignant cells [12]; Ectopic expression of JAK2 partially reversed the inhibition of cell pro- liferation, invasion and migration ...
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Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity
... Members of the EGFR family are potent activators of the PI3K/Akt pathway, contributing to endocrine resis- tance in breast tumors. Therefore, we investigated the effect of ER b expression on EGFR, HER2 and HER3 protein ...
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Expression profiles of long noncoding RNAs in lung adenocarcinoma
... of upregulation or downregulation: LINC00152, LINC00691, LINC00578, LINC00668, LINC00710, and LINC00607, and employed quantitative PCR to detect their expression in 90 pairs of lung adenocarcinoma tissues ...
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Effect of gyromagnetic fields on human prostatic adenocarcinoma cells
... GMFs could potentially inhibit cell proliferation, induce apoptosis, and regulate tumor cell polarity conditions through the downregulation of Akt signaling, upregulation o[r] ...
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HESPERIDIN A BIOFLAVONOID MODULATES THE EXPRESSION LEVELS OF SNCA AND PARKIN IN 6-HYDROXYDOPAMINE INDUCED NEUROTOXICITY IN RATS
... mild downregulation in SNCA and ...significant downregulation in SNCA and LRRK2, whereas standard L-Dopa rats showed mild downregulation in SNCA and LRRK2 ...mild upregulation in Parkin and ...
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Fatty acid-induced CD36 expression via O-GlcNAcylation drives gastric cancer metastasis
... that upregulation of O-GlcNAcylation by TMG treatment significantly increased the levels of CD36 mRNA in cells, whereas the downregulation of O-GlcNAcylation caused by knocking out OGT reduced the ...
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Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease
... [29-31]. Upregulation of genes related to glucose and fatty acids metabolism is highly relevant to ...for upregulation of genes involved in mitochondrial biogenesis are not evident in the current study; ...
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Original Article Ang (1-7) improves cardiac function after resuscitation from cardiac arrest
... MasR gene expression in myocardial tissues was enhanced by Ang 1-7 ligation, which lead to the downregulation of IncAng362 and miR222 expression and consequent upregulation of Pten gene [r] ...
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Original Article Identification and characterization of divergent regulated genes correlates with reduced survival times in cancer genome atlas (TCGA) datasets
... both upregulation and down- regulation and are associated with reduced survival times may reflect the complexity of gene regulation in ...that upregulation or downregulation of a spe- cific gene ...
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PubMedCentral-PMC4896545.pdf
... Results. Cultured triple mutant astrocytes gained unlimited self-renewal and multilineage differentiation capacity. These cells har- bored significantly altered chromatin landscapes that were associated with ...
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MicroRNA 34a and microRNA 21 play roles in the chemopreventive effects of 3,6 dihydroxyflavone on 1 methyl 1 nitrosourea induced breast carcinogenesis
... global upregulation of miR-21 and downregulation of miR-34a in breast carcinogenesis could be reversed by 3,6-DHF, which significantly upregulated miR-34a expression and decreased miR-21 expression - ...
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The Toll-like Receptor 2 (TLR2)-related Immunopathological Responses in the Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
... MS, upregulation of Th1/Th17 cells, downregulation of regulatory T (Treg) cells, induction of interleukin-17 positive γδ T cells (IL-17 + γδ T cells), inhibition of oligodendrocyte maturation, induction a ...
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<p>Acetyl-11-Keto-β-Boswellic Acid Exerts the Anti-Cancer Effects via Cell Cycle Arrest, Apoptosis Induction and Autophagy Suppression in Non-Small Cell Lung Cancer Cells</p>
... Inhibiting the PI3K/Akt pathway could target cancer cell biology, suppress cell growth, and induce cell apoptosis. 33 Akt is a key downstream effector of PI3K, and p-Akt, a phosphorylated protein of Akt, is downregulated ...
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Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression
... the upregulation of erbB3 mRNA levels (Figure 3A), while the downregulation of EGFR and ErbB2 in these two cell lines, and of all ErbB receptors in epithelial R11 and S11 cells, is related to protein ...
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MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression
... miR-520g upregulation increased EOC cell proliferation, induced cell cycle transition and promoted cell invasion, while miR-520g downregulation inhibited tumor-related ...or downregulation of ...
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Long non-coding RNA Malat1 activated autophagy, hence promoting cell proliferation and inhibiting apoptosis by sponging miR-101 in colorectal cancer
... proliferation assay ( a ), flow cytometry (FCM) assay ( b ) and Western blot assay ( c ) show the effects of Malat1 downregulation or Malat1 upregulation on HCT116 and SW620 cell prolife[r] ...
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Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet
... Using the cross-fostering model, we were able to fur- ther confirm the importance of maternal HFD consump- tion during gestation to hepatic lipid metabolism and also investigate whether the suckling period would exert ...
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Original Article Genomic alterations and protein expression of STAT4 in pancreatic cancer: a study of bioinformatics based on public data and immunohistochemistry validation with 241 tissue samples
... United States [1]. But the pathogenesis of pan- creatic cancer remains unclear. STAT family, which consist of STAT1~STAT6, is a group of protein binding DNA that can regulate cell pro- liferation differentiation and ...
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