Drug candidate
Guaiacol as a drug candidate for treating adult polyglucosan body disease
... patient–derived skin fibroblasts, was based on the operational definition of polyglucosan as an entity that can be stained by PAS and be insensitive to digestion by the glycogen-digesting enzyme diastase (up to certain ...
18
Original Article BG40018: a promising drug candidate for the treatment of invasive fungal infections
... ment for daily parenteral administration associ- ated with high cost limited its clinical use [18]. Various strategies to improve solubility and extend the elimination half-life were used in modifying anidulafungin. ...
7
Predicting target proteins for drug candidate compounds based on drug-induced gene expression data in a chemical structure-independent manner
... for drug/compound target prediction are based on chemical structure, including the chemogenomic ...obtain drug-induced gene expression ...of drug-induced gene expression profiles, and has thereby ...
10
In Silico Drug Designing of Protease Inhibitors to Find the Potential Drug Candidate for HIV1
... Aided Drug Designing of Protease Inhibitors to find the potential drug candidate for HIV1 based on different type potential parameters Homology modeling, also known as comparative modeling of ...
5
Identification of novel drug candidate against Mycobacterium Tuberculosis InhA protein through Computer aided drug discovery
... Tuberculosis is a common and often deadly infectious disease caused by Mycobacteria. WHO estimates that around eight million people are suffering from tuberculosis every year. The Administration of antibiotics fails due ...
9
AWZ1066S, a highly specific anti drug candidate for a short course treatment of filariasis
... safe drug that can kill the adult filaria ...and drug metabolism/pharmacokinetic (DMPK) features of a thienopyrimidine/quinazoline scaffold derived from phenotypic ...This candidate molecule is ...
6
Profiling of the anti malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum
... The parasite reduction ratio after a single dose, i.e. the speed of action of the molecule, is a quality feature of an anti-malarial drug as recently emphasized by the Medicine for Malaria Venture (MMV) [61]. ...
10
In silico designing of DASM with Pyrazofurin, a possible drug candidate for Anthrax
... One of the approaches followed in the present study was that of finding a suitable molecule designed to inhibit the Furin through in silico drug designing technique. To achieve this, a base molecule which has ...
6
Identification of drug candidate for osteoporosis by computational bioinformatics analysis of gene expression profile
... identify candidate small molecules capable to reverse the gene changes of osteoporosis, we performed computational bioinformatics analysis of the derived gene signature using the Connectivity ...
7
Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate
... Controlled drug release systems with appropriate carriers, which include liposomes, dendrimers, micro sponges, microparticles, and micelles, have been employed to increase the therapeutic effectiveness and ...
13
Impact Factors in the Process Development for Therapeutic Antibodies
... antibody drug candidate, it is necessary to start the process optimization as early as possible, and it is better to start before the determination of the cell line ...
7
Molecular docking and High throughput screening of potent inhibitor to gp46SU involved in ATLL through drug design studies
... The potentiality of our studies are immense in terms of good target and the ligand molecules. The protein of our interest shows the quality and importance of our studies. In our studies all the molecules that we designed ...
7
“Formulation and Evaluation of Ketoprofen by Liquisolid Compact Method” by P.V.Kamala Kumari, M.Trinadha Rao, Y. Srinivasa Rao, M. Aswini, India.
... model drug for this study as it is class II drug which has poor solubility in water and thus ideal candidate for evaluating rapid release potential of liquisolid ...that drug candidate ...
5
Journal of Applied Pharmaceutical Science
... suitable drug candidate for the formulation of hydrophilic matrix tablets and the formulated tablets showed compliance for various physiochemical ...vitro drug release studies, the decrease in the ...
5
Drug Repositioning: Concept, Classification, Methodology, and Importance in Rare/Orphans and Neglected Diseases
... new drug candidate and measuring their safe dosage (Brunton et ...the drug is ...new drug is already ...and drug interactions (Brunton, 2012; FDA, ...
9
A REVIEW ON POLYMER DRUG CONJUGATE – WHAT, WHY AND HOW?
... as drug delivery systems that exhibit their therapeutic activities by means of releasing smaller therapeutic drug molecules from a polymer chain molecule for a prolonged period of time which results in ...
11
Synthesis, Characterization and Drug-Likeness Predictions of 1,3-Thiazole and Benzothiazole Derivatives
... Drug likeness is a qualitative criterion used for drug like property of the compounds. Different structural and molecular properties like hydrophobicity, hydrogen bond characteristics, molecule size etc. ...
6
Review on – Pharmaceutical product development Stages
... the drug candidate itself, (b) selection of formulation components, (c) API & drug product manufacturing processes, (d) determination of the most appropriate container closure system, (e) ...
6
Active repurposing of drug candidates for melanoma based on GWAS, PheWAS and a wide range of omics data
... Cutaneous malignant melanoma is a highly dangerous dis- order that has high mortality and less survival time. Due to the non-availability of treatment drugs, treating the dis- ease is costly and painful. We have used a ...
11
How Long to Treat with Bisphosphonates?
... At present, there are increased safety concerns surrounding the long term use of bisphosphonates, including atypical femoral fractures (AFFs), osteonecrosis of the jaw (ONJ), and esophageal cancer [11] [12], along with ...
7