Drug clearance
A non lethal malarial infection results in reduced drug metabolizing enzyme expression and drug clearance in mice
... in clearance of four dif- ferent drugs to the observed down-regulation of most P450 mRNAs and proteins studied, although changes to hepatic blood flow and plasma protein binding could also contribute to the ...
16
Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
... total drug concentrations collected in a limited number of ...unbound drug concentrations. In our study, the median cefazolin clearance value (coefficient of variation, %) for a neonate with a birth ...
273
Applicability of the Principles of Developmental Pharmacology to the Study of Environmental Toxicants
... relative efficacy and toxicity are not reliable. In ad- dition, children have been shown to be a heteroge- neous population with the process of growth and maturation from birth to adulthood occurring in a nonlinear ...
6
Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury
... nonrenal clearance could be considered ‘hidden’ drug clearance changes because they usually would go ...nonrenal clearance exist for other drugs, we are not aware of other published ...
9
Unexpected excessive apixaban exposure: case report of a patient with polymorphisms of multiple apixaban elimination pathways
... known drug interaction was ...creatinine clearance of 40 ml/min, the average increase in Cmax is ...to drug clearance of the remaining individual pathways increases, indicating that concurrent ...
6
Cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy: a Monte Carlo simulation study
... on drug pharmacokinetics were ...total drug clearance, non-renal clearance, extraction coefficient, and elimination rate constant [8, 9, ...
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Does Beta-lactam Pharmacokinetic Variability in Critically Ill Patients Justify Therapeutic Drug Monitoring? A Systematic Review
... in drug clearance are ...therapeutic drug monitoring (TDM) and individualized dosing to ensure the achievement of pharmacodynamic targets associated with rapid bacterial killing and optimal clinical ...
11
An Overview on Intranasal Drug Delivery System: Recent Technique and Its Contribution in Therapeutic Management
... Nasal drug administration has been used as an important another route for the systemic availability of ...nasal drug delivery ...of drug formulations in the nasal cavity, for improving nasal ...
7
Exchange Transfusion in the Treatment of Severe Theophylline Poisoning
... endogenous drug clearance. Finally, in making the decision to perform exchange transfusion, several pre- dictors of a favorable prognosis after theophylline poisoning were already presen[r] ...
5
A STUDY ON DRUG DOSE ADMINISTRATION IN GERIATRICS WITH RESPECT TO CREATININE CLEARANCE RATE
... Creatinine clearance is a valid predictor of nephritic function. The drug clearance is similar to that of creatinine ...the drug clearance is decreased it accumulates in the body lead ...
7
Quantitative Estimation of P-glycorptein-Mediated Drug Transport by Mechanistically Modeled Intrinsic Clearance
... new drug submission rejections and early development terminations, for many pharmaceutical agents ...bioavailability, clearance and tissue distributions of clinically important ...Characterizing ...
147
Accelerated drug release and clearance of PEGylated epirubicin liposomes following repeated injections: a new challenge for sequential low-dose chemotherapy
... which, in turn, induces the release of drugs encapsulated in the liposomes. Interestingly, the rapid release of EPI occurred during the first 30 minutes, which was very similar to the enhanced blood clearance ...
12
Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells
... on drug metabolizing enzymes impacting drug efficacy and resistance (Table ...other drug resistance-related genes (5-hydroxytryptamine receptor 2A [HTR2A], apolipoprotein E [Apo E], aldehyde ...
10
Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance
... Interestingly, HIV-1 infection affects the size and or number of endosomes as a reflection of Rab protein expression (G. Zhang, unpublished observation). We posit that such virus-induced al- terations in endosomes are ...
10
MODERN ENCROACHMENT AND PROVOCATION IN NASAL DRUG DELIVERY SYSTEM
... INTRODUCTION: Oral drug delivery is the most desirable route for the drug administration. Whenever systemic effects are indented but oral bioavailability of some compounds has promoted the search of more ...
7
Enhanced Skin Permeation of Verapamil Hydrochloride Through Ethanolic Liposomes
... The aim of present investigation was to formulate and characterizeethosomes as a delivery system for transdermal delivery of verapamil hydrochloride, a drug having low oral bioavailability (approx 20%), short ...
15
Enhanced Skin Permeation of Verapamil Hydrochloride ThroughEthanolic Liposomes
... aqueous drug solution, was applied to the epidermal surface of the rat skin using ...In-vitro drug release study from ethosomes was repeated with cellophane membrane using the same method as described ...of ...
15
Studies on renal safety and preventive analgesic efficacy of tramadol and parecoxib in dogs : thesis in fulfilment of the degree of Doctor of Philosophy in Veterinary Clinical Science, Institute of Veterinary Animal and Biomedical Sciences, College of Sciences, Massey University, Palmerston North, New Zealand
... iohexol clearance test was conducted twice on each dog, before and 24 hours after analgesia and induction of ...iohexol clearance test was conducted following baseline threshold testing of ...
153
STEREOCHEMISTRY AND ITS ROLE IN DRUG DESIGN
... In terms of substituents on the quinolone nucleus, hydrophobic groups are required at Nl, to enhance interactions between individual molecules, and the steric bulk of substituents at C7 does not appear to be a critical ...
16
Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4
... unfavorable drug–drug interactions and ...safe drug combination regimen, dose adjustment, or discontinuation of therapy when toxic drug interactions occur), therapeutic drug monitoring, ...
12