Drug Combination
Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination
... overcome drug resistance, combination therapy has been suggested to improve the effects of targeted therapeutics ...of drug combinations largely depends on the network ...of drug combinations ...
12
Nanocarrier-based drug combination therapy for glioblastoma
... cells, drug efflux pumps and DNA damage repair mechanisms. Drug combination therapies have shown increasing benefits against those ...of drug combinations with or without nanocarriers and the ...
18
Quantifying the pharmacology of antimalarial drug combination therapy.
... antimalarial drug class, the artemisinins, has caused the World Health Organization to produce an emergency response in the Greater Mekong Sub-region to reduce its putative impact on the effectiveness of malaria ...
7
Incidence of Potential Drug–Drug Interactions in Cardiac Patients in a Tertiary Care Hospital
... of Drug-Drug Interaction inPrescription Dispensed by Community and Hospital ...of drug combination generally accepted as carrying a risk of severe ...Potential drug interactions were ...
82
HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DRUG RELEASE OF LEDIPASVIR AND SOFOSBUVIR IN LEDIPASVIR AND SOFOSBUVIR TABLETS
... fixed-dose drug combination product with Sofosbuvir used for the treatment of chronic hepatitis ...this drug the main treatment available was weekly injections of pegylated interferon with weight ...
8
Culture and sensitivity pattern of micro-organism isolated from diabetic foot infections in a tertiary care hospital
... of drug in infection caused by ...Conclusion- Combination of ciprofloxacin (fluoroquinolones) and amikacin is a better choice of drug combination for infection caused by Gram positive and ...
7
Repurposing sertraline sensitizes non–small cell lung cancer cells to erlotinib by inducing autophagy
... erlotinib combination reduces cell viability in ...in combination with erlotinib, an EGFR TKI, in the above NSCLC cell ...the combination of sertraline and erlotinib was more effective to inhibit ...
17
Systems biology approaches for advancing the discovery of effective drug combinations
... current drug combination prediction methods have primarily focused on targeting the predominant tumor ...optimal drug combina- tions for heterogeneous tumors by maximizing efficacy and minimizing ...
15
Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs
... of drug combinations, we need to know whether or not a drug combination exerts a synergistic effect (reviewed in ...synergistic drug combination requires a larger than expected dose to ...
9
A comparative study for efficacy of Povidone Iodine in combination with Ornidazole and Metronidazole in anaerobic isolates
... in combination with Metronidazole 1% gave MIC value of 1 mg/ml and ...the combination of Povidone iodine 5% and Metronidazole was more effective than other drug/ drug combinations, as it gave ...
6
EFFICACY OF UNIQUE COMBINATION OF HERBS IN MUKHADUSHIKA .......
... herbal drug combination of Amalki, Kutki, Manjishtha and Khadir was selected for internal administration and herbal drug combination of Amalki, Lodhra, Haridra and Priyangu was selected for ...
6
Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment
... The MTT assay was conducted to evaluate the effect of the individual drugs, drug combination, or drugs loaded into LPH on different cell lines. Most treatments resulted in a dose-dependent effect in which ...
9
FORMULATION AND EVALUATION OF METOPROLOL TARTARATE FLOATING MICROSPHERES
... on drug entrapment efficiency and particle ...in combination with ethyl cellulose to increase the drug release from microspheres but at the same time drug entrapment efficiency and yield of ...
11
Exploiting Drug Repositioning for Discovery of a Novel HIV Combination Therapy
... either drug or sol- vent (DMSO) treated, and then expression of the target genes is assessed by flow cytometry to determine the percentage of cells that have been ...
9
Fabrication of multifunctional triple-responsive platform based on CuS-capped periodic mesoporous organosilica nanoparticles for chemo-photothermal therapy
... Results: Upon entering into cancer cells, the CuS gatekeeper was opened with the breaking of disulfide bonds and the DOX release from YSPMOs(DOX)@CuS in response to the intra- cellular acidic environment and external ...
17
Drug-resistant tuberculosis and advances in the treatment of childhood tuberculosis
... of drug- susceptible TB, then WHO recommends that they be given preventive treatment without the need for TST or IGRA testing ...both drug-susceptible (DS) [22] and drug-resistant (DR) TB disease ...
13
Mapping of Global Regulatory Requirements for Drug – Device Combination Product
... of Combination Product A constituent part of a combination product is an article in a CP that can be distinguished by its regulatory identity as a drug, device, or biological ...product. ...
5
FORMULATION AND EVALUATION OF FIXED DOSE COMBINATION PRODUCTS OF ANTITUBERCULAR DRUG
... 5. Saranjit Singh, Maria pan, T.T, Sankar, R,Sarda, N, Baljinder Singh. A critical review of the probable reasons for the poor/variable bioavailability of rifampicin from anti- tubercular fixed-dose combination ...
10
Scope of claim coverage in patents of fufang Chinese herbal drugs: Substitution of ingredients
... the drug composition, thereby perform- ing different functions. Herbal drug patent owners, nevertheless, may argue that herbal drugs are very dif- ferent from chemical drugs due to the complex nature of ...
6
Effectiveness and safety evaluation of oral cefixime and moxifloxacin fixed dose combination in lower respiratory tract infections
... the combination of these two classes of drugs in LRTI will help the patients in providing them a multimodal empiric coverage with probably additive effect, increasing the patient compliance and tackling the issue ...
6