Drug metabolism
Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients
... complicated drug metabolism in dialysis patients may be affected also by systemic inflammation, this adds novel challenges to correct drug dosing in this inflamed patient population ...of drug ...
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The Impact of Cancer Associated Inflammation on Cytotoxic Drug Metabolism and Nutritional Status: The Sydney Cancer Centre Experience
... As mentioned earlier, elevated inflammatory markers have been associated with the development and progression of the cancer cachexia syndrome. Therefore it is likely that nutritional status might be impaired in other ...
6
Phenotyping of Drug Metabolism in Infants and Children: Potentials and Problems
... in drug-metabolizing enzymes is a predominant cause of variability in drug metabolism, along with physiologic, pathophysiologic, and environmental factors (Table ...adverse drug reactions have ...
6
Effect of health foods on cytochrome P450-mediated drug metabolism
... Background: Health foods have been widely sold and consumed in Japan. There has been an increase in reports of adverse effects in association with the expanding health food market. While health food-drug ...
11
Endotoxin administration to humans inhibits hepatic cytochrome P450 mediated drug metabolism
... In experimental animals, injection of gram-negative endotoxin (LPS) decreases hepatic cytochrome P450-mediated drug metabolism. To evaluate this phenomenon in a human model of gram-negative sepsis, LPS was ...
7
Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury
... renal drug clearance is an obvious consequence of acute kidney injury ...nonrenal drug clearance is also ...hepatic drug metabolism and transporter function are components of nonrenal ...
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CLONING AND SEQUENCING OF SOME RELEVANT DRUG METABOLISM GENES IN CATTLE: THE PROGRAMMA GALILEO 2003 SUMMARY REPORT
... The cytochrome P450 (CYP) superfamily comprises a large family of haem-containing phase I enzymes, which act mainly as monooxygenases. Among CYPs, those included in gene families 1-4 are mainly involved in drug ...
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HEXOSE MONOPHOSPHATE AND OTHER PATHWAYS TO DRUG METABOLISM
... of drug metabolism occur in the liver, an organ devoted tothe synthesis of many important biologically functional proteins, which also has thecapacity to mediate chemical transformations of xenobiotics ...
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Drug metabolism related genes as potential biomarkers: analysis of expression in normal and tumour breast tissue
... in drug metabolism has been detected in every different type of tissue studied to date, both normal and tumour; techniques employed for detection include RT-PCR, Western blot, immunocytochemistry and ...
10
Hepatic Drug Metabolism, Uremic Toxins and Bacterial Composition Over Chronic Kidney Disease Progression
... L-Carnitine is a required nutrient primarily obtained through the diet in meat, eggs and protein-rich foods including soy (Klaassen & Cui, 2015). In contrast to an increase in L- carnitine observed in the heart and ...
122
Drug metabolism and clearance system in tumor cells of patients with multiple myeloma
... local drug metabolism and detoxification process. The role of drug metabolism and clearance system has not been satisfactorily investigated in Multiple Myeloma (MM), a malignant plasma cell ...
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Development of novel methodologies for using ICP MS in bioanalysis and drug metabolism
... in drug and xenobiotic metabolism studies of halogen- containing compounds (Cl, Br and I) [40,41,47, 51], as well as initial studies on S and P-containing compounds ...
244
Application of capillary zone electrophoresis methods for the investigation of in vitro drug metabolism
... On application of a voltage the solute ions migrate more rapidly through the higher electric field of the sample plug until they reach the boundary with the lower electric field of the r[r] ...
113
Objectives. Drug Metabolism. Drug Dynamics. Lecture 11
... related to alcohol use are severe and stopping alcohol consumption results in withdrawal symptoms.. Causes of Abuse and Alcoholism[r] ...
11
DMET TM (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine
... and drug associations at level of cytochrome P450 (CYP) enzymes, receptors, transporters, targets and, more recently, human-leukocytes antigens (HLAs) ...and metabolism enzymes (CYP3A4, and CYP3A5, CYP1A1, ...
23
FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism.
... Activating mutations and/or overexpression of fibroblast growth factor receptor 3 (FGFR3) are commonly observed in bladder cancer, making FGFR3 an attractive therapeutic target in this disease. Recently FGFR3 gene ...
39
Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotypes in black Americans
... prevalence of the deficient trait in blacks and whites. We conclude that the same CYP2D6 mutations lead to a loss of functional expression in blacks and whites, but American blacks have a lower prevalence of the ...
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Gut instincts: CYP3A4 and intestinal drug metabolism
... Quantitative differences in hepatic and intestinal CYP3A4 activity In an elegant study of intestine- and liver-selective transgenic expression of CYP3A4 on a complete mouse Cyp3a gene knockout background, van Herwaarden ...
5
Interplay Between the Host, the Human Microbiome, and Drug Metabolism
... multi- drug resistance-associated protein 2/ATP-binding cassette [Mrp2/Abcc2]) and many phase two enzymes (UDP glucu- ronosyltransferase 1a1 [Ugt1a1], sulfotransferase 2b1 [Sult2b1], and Glutathione S-Transferase ...
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Molecular and macromolecular alterations of recombinant adenoviral vectors do not resolve changes in hepatic drug metabolism during infection
... in drug-drug interactions, potential therapeutic failures of vital medica- tions and secondary health problems due to interruption of natural biochemical processes during microbial ...
17