Drug Naive
<p>COMT polymorphism regulates the hippocampal subfield volumes in first-episode, drug-naive patients with major depressive disorder</p>
... Purpose: Compared with healthy subjects (HS), patients with major depressive disorder (MDD) exhibit volume differences that affect the volume changes in several areas such as the limbic, cortical, subcortical, and white ...
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<p>Genetic effects on white matter integrity in drug-naive patients with major depressive disorder: a diffusion tensor imaging study of 17 genetic loci associated with depressive symptoms</p>
... The RERE polymorphism was associated with WM altera- tions of the ATR, cingulum, CST, IFOF, ILF, SLF, UF, forceps major, and forceps minor in first-episode and drug- naive MDD patients, which may be at ...
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Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients
... Background: Recent magnetic resonance spectroscopy (MRS) studies report that glutamine is altered in the brains of schizophrenic patients. There were also conflicting findings on glutamate in cerebrospinal fluid (CSF) of ...
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Use of Massively Parallel Ultradeep Pyrosequencing To Characterize the Genetic Diversity of Hepatitis B Virus in Drug-Resistant and Drug-Naive Patients and To Detect Minor Variants in Reverse Transcriptase and Hepatitis B S Antigen
... (HBV) drug resistance mutations, although only mutations present in viral quasispecies with a prevalence of > 20% can be detected by sequencing, and only known mutations are detected by ...five ...
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Utility of a Relatively Affordable In House HIV 1 Genotyping Assay for Drug Resistance Testing among Non B HIV 1 Infected Drug Naive Patients in Nigeria
... determine drug resistance mutations among treatment-naive ...infected drug-naive adult patients attending a tertiary hospital Jos, Nigeria were subjected to HIV-1 RNA extraction, reverse ...
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Structural and functional brain abnormalities in drug-naive, first-episode, and chronic patients with schizophrenia: a multimodal MRI study
... first-episode drug-naive SZ (FESZ) patients, 44 medi- cated chronic SZ (CSZ) patients, and 56 normal controls (NCs) and acquired their structural and resting-state functional magnetic resonance imaging ...
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Prevalence of Human Immunodeficiency Virus Drug Resistance Mutations and Subtypes in Drug Naive, Infected Individuals in the Army Health Service of Rio de Janeiro, Brazil
... efficacious drug regimens, which prevent the generation of new mutations, or of fewer transmissions of resistant ...in drug- naive individuals to restore the fitness of infecting ...
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The PTAP sequence duplication in HIV 1 subtype C Gag p6 in drug naive subjects of India and South Africa
... Methods: In a prospective follow-up study, 65 HIV-1 seropositive drug-naive subjects were monitored in two different clinical cohorts of India for 2 years with repeated sampling at 6-month intervals. The ...
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Both Human Immunodeficiency Virus Cellular DNA Sequencing and Plasma RNA Sequencing Are Useful for Detection of Drug Resistance Mutations in Blood Samples from Antiretroviral Drug Naive Patients
... transmitted drug resistance may be short term provided that HAART is guided by antiretroviral resistance testing (15, ...for drug resistance testing, little is known about the persistence of drug ...
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A Study of Basal Thyroid Functions in Drug Naive First Episode Depression.
... Methods: S ample of 50 , of whom 25 are newly diagnosed as depressive disorder according to ICD-10 DCR, who are drug naive and equal number of healthy, age and sex matched controls were included in this ...
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Decreased glutathione levels and impaired antioxidant enzyme activities in drug naive first episode schizophrenic patients
... This study has some limitations. Diagnostic groups were relatively small, and it was difficult to establish in advance a sample size to perform the data analyses because of the paucity of studies with similar design ...
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Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD
... patients with MDD and HCs. The difference of the GM volume between the MDD and HC groups was not sig- nificant; however, the rs-fMRI indexes were found to be different between the MDD and HC groups. For the differ- ...
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Research Paper: Neuropsychological Functioning in Obsessive-Compulsive Washers: Drug-Naive Without Depressive Symptoms
... Another important finding of the current research was the difference in global performance of the groups in Go/No-Go Task, which indicated that the patients with OCD had a weaker beha[r] ...
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Carbohydrate Intake Is Correlated with the Glycated Albumin to Glycated Hemoglobin Ratio in Drug Naive Patients with Type 2 Diabetes
... In conclusion, the carbohydrate index carbohydrate intake per body weight is correlated with the GA/HbA1c ratio, a marker reflecting postprandial hyperglycemia, in patients with untreate[r] ...
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Psychiatric Morbidity in Drug-Naive Hypothyroid Patients.
... TABLE-13 ANXIETY DISORDER IN HYPOTHYROID PATIENTS GROUP Anxiety Disorder Case 75 Control 75 Chi-square test n % n % Present 9 12% 2 2.7% χ2=4.81 p=0.03 Absent 66 88% 73 97.3% Significant[r] ...
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Multi-Drug-Resistance in Drug-Naive and Drug- Exposed Ovarian Cancer Cell Lines Responds Differently to Cell Culture Dimensionality
... The potential clinical implications of our findings are dual. First, considering the role of clustering of OC cells in intrinsic and acquired chemoresistance, our results provide a new possible explanation for the ...
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Hyperprolactinemia and insulin resistance in drug naive patients with early onset first episode psychosis
... in drug-free patients, suggesting that schizophrenia itself may be characterized by an ab- normal regulation of PRL levels [5, ...antipsychotic naive patients with first episode psychosis (FEP) had ...
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PubMedCentral-PMC5240185.pdf
... In drug-naive controls, core dopamine signals did not discriminate between reward size at any point, while in the shell dopamine encoded magnitude differences only in a slower postpeak ...
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In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors
... first-line drug for the treatment of drug-naive patients with HIV-1 infection and those who harbor multidrug-resis- tant HIV-1 (HIV-1 MDR ) variants and do not respond to pre- viously existing highly ...
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Investigation of the serum levels of anterior pituitary hormones in male children with autism
... Based on interviews and available records, including those from hospitals, the diagnosis of autism were made based on the Diagnostic and Statistical Manual, Fourth Revision, Text Revision (DSM-IV-TR) criteria. The Autism ...
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