drug repositioning
Drug repositioning for personalized medicine
... of drug repositioning candidates involve finding existing drugs that can modulate specific disease phenotypes (path 2), finding new drug-target interactions (path 3), finding new roles for existing ...
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Connecting genetics and gene expression data for target prioritisation and drug repositioning
... successful drug – disease combinations tend to dis- play a significant overlap between the genetic background of the disease and the tran- scriptional response to the drug used to treat the ...tested, ...
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Therapeutic drug repositioning using personalized proteomics of liquid biopsies
... and genome-wide association studies (GWAS) and use large study populations to define disease signatures. In practice, however, a patient’s genetic profile usually only denotes risk, which may do little to guide treat- ...
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Identification of FDA approved drugs with activity against Lassa virus- A computational drug repositioning approach.
... of drug resistant strains have compromised the efficacy of most antiviral agents; some have troublesome and unbearable side effects while some are less efficacious (Kühnert et ...2018). Drug ...
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Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs
... target-based drug repositioning strategy should not choose the drugs sharing targets with epilepsy-causative genes, but consider the drug–target interaction ...
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Alzheimer’s disease master regulators analysis: search for potential molecular targets and drug repositioning candidates
... Indeed, regulatory networks centered in TF have already been shown effective in identifying cancer drivers [17, 18, 32]. Furthermore, this approach is also gradually becom- ing the methodology of choice to study ...
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An antiviral drug combinational studies against hiv- a computational drug repositioning approach
... Nigeria was rated second HIV most prevalent country worldwide (Awofala and Ogundele, 2018). Currently available anti-retroviral agents include nucleosides reverse transcriptase inhibitors (NRTIs), non-nucleosides reverse ...
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A network based approach to drug repositioning identifies plausible candidates for breast cancer and prostate cancer
... computational drug repositioning methods, which screen drugs based on the anti-correlation between simi- lar gene and disease signatures, omitting the functional correlation between ...ranked drug ...
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Identification of fda approved drugs with activity for hiv- a computational drug repositioning approach
... Nigeria was rated second HIV most prevalent country worldwide (Awofala and Ogundele, 2018). Currently available anti-retroviral agents include nucleosides reverse transcriptase inhibitors (NRTIs), non-nucleosides reverse ...
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Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning
... Nevertheless, we discovered two similar subnetworks in the “fibroblast” (top 25) and “fibroblast” (top 30), which contained druggable genes (CACN1H, SLC22A3, and P2RX1) that implicated in cation (calcium) homeo- stasis ...
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Drug Repositioning Inferred from E2F1-Coregulator Interactions Studies for the Prevention and Treatment of Metastatic Cancers
... and drug repositioning [62] promote a paradigm shift in drug research and ...one drug can show efficacy against diseases with distinct clinical manifestations ...hand, drug ...
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An antiviral Drug combinational studies against Lassa virus- A computational drug repositioning approach
... of drug resistant strains have compromised the efficacy of most antiviral agents; some have troublesome and unbearable side effects while some are less efficacious (Kühnert et ...2018). Drug ...
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Drug repositioning : a machine-learning approach through data integration
... for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information ...a drug-centered ...
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<p>Individualized Drug Repositioning For Rheumatoid Arthritis Using Weighted Kolmogorov–Smirnov Algorithm</p>
... Presently, drug repositioning has drawn broad attention from the pharmaceutical companies and research ...traditional drug development process, drug repositioning replenishes the drying ...
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Exploiting Drug Repositioning for Discovery of a Novel HIV Combination Therapy
... by drug resistance, which emerges when drug levels are not high enough to sufficiently inhibit viral ...one drug often confers resistance to other members of the same drug ...of drug ...
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Drug repositioning as a route to anti malarial drug discovery: preliminary investigation of the in vitro anti malarial efficacy of emetine dihydrochloride hydrate
... of drug candidates fail during development, this ap- proach which utilizes bioactive compounds with known safety profiles must necessarily be advantageous ...malaria, drug repositioning may not only ...
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Recent Advances in Drug Repositioning for the Discovery of New Anticancer Drugs
... ‘activity-based drug repositioning’ we shall use in this review refers to the application of actual drugs for ...silico drug repositioning’ utilizes public databases and bioin- formatics tools ...
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Niacin as a drug repositioning candidate for hyperphosphatemia management in dialysis patients
... With its cost-effectiveness and additive effects as a tradi- tional dyslipidemia treatment, niacin can be a promising can- didate for drug repositioning as a phosphorus-lowering agent in ESRD patients. ...
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PREDICTION OF NOVEL THERAPEUTIC INDICATION FOR ROSIGLITAZONE USING ITS REPORTED CLINICAL SIDEEFFECTS: DRUG REPOSITIONING BY PHARMACOVIGILANCE APPROACH
... of drug repositioning for known molecules with well characterized safety and efficacy profiles could help us to identify the new therapeutic indication for unintended disease and its better transition for ...
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Network mirroring for drug repositioning
... Next, we performed candidate drug selection and drug repositioning for dementia. Three similar diseases for dementia were selected from 2890 diseases, which is equivalent to 0.1% (δ = 0.1) of the ...
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