DRUG-RESISTANCE MUTATIONS
Emergence of HIV 1 drug resistance mutations in mothers on treatment with a history of prophylaxis in Ghana
... viral mutations generated. This study investigated HIV-1 drug resistance profiles in mothers in selected centres in Ghana on treatment with a history of ...Genotypic Drug Resistance ...
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Antiretroviral Drug Resistance Mutations among HIV Treatment Failure Patients in Tehran, Iran
... Methods: Blood sample was collected from 51 patients who suspicious treatment failure in the center of Imam Kho- meini Hospital, Tehran, Iran in 2015. Viral voluntary counseling and testing load test was done and the ...
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Sensitivity and Specificity of the ViroSeq Human Immunodeficiency Virus Type 1 (HIV 1) Genotyping System for Detection of HIV 1 Drug Resistance Mutations by Use of an ABI PRISM 3100 Genetic Analyzer
... identify drug resistance mutations in HIV-1 protease and the first 335 codons of HIV-1 ...of drug resistance ...of resistance to FDA-approved drugs based on the detection of ...
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<p>Antiretroviral drug resistance mutations among patients failing first-line treatment in Hanoi, Vietnam</p>
... Results: Drug resistance mutations were ...with drug resistance mutation, ...genetic mutations resis- tant to NNRTIs, G190S mutation was the highest ...genetic mutations ...
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Stochastic Interplay between Mutation and Recombination during the Acquisition of Drug Resistance Mutations in Human Immunodeficiency Virus Type 1
... of drug resistance, we recently developed a population genetic model of recombination in HIV ...of drug resis- tance depends on how mutations interact to determine viral ...if mutations ...
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Detection of Cytomegalovirus Drug Resistance Mutations by Next Generation Sequencing
... by drug resistance associated with mu- tations in the phosphotransferase UL97 and the DNA polymerase ...CMV drug resistance mutations in clinical plasma specimens using a microfluidics ...
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Moderate prevalence of HIV-1 transmitted drug resistance mutations in southern Brazil
... of mutations asso- ciated with drug resistance, which can be transmitted to uninfected ...Transmitted drug resistance mutations (TDRM) is associated with impaired outcomes from ...
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Pre treatment minority HIV 1 drug resistance mutations and long term virological outcomes: is prediction possible?
... Briefly, cDNA samples were fragmented using an ultrasonication approach and the resulting fragments were purified and size selected, end repaired and an illu- mina specific adapter sequence ligated. Following quan- ...
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Using Aspergillus nidulans To Identify Antifungal Drug Resistance Mutations
... single-gene mutations. In each case, the resistance was specific to calcofluor white, since there was no cross-resistance to caspofungin ...protracted drug therapy once drug ...
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Prevalence of Human Immunodeficiency Virus Drug Resistance Mutations and Subtypes in Drug Naive, Infected Individuals in the Army Health Service of Rio de Janeiro, Brazil
... efficacious drug regimens, which prevent the generation of new mutations, or of fewer transmissions of resistant ...these mutations and their disappearance in drug- naive individuals to ...
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KRDS: a web server for evaluating drug resistance mutations in kinases by molecular docking
... However, drug resistance has emerged as a major obstacle to cancer ...therapy. Resistance to drugs has various underlying mechanisms, including the acquisition of mutations at drug ...
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Effect of Transmission Reduction by Insecticide-Treated Bednets (ITNs) on Antimalarial Drug Resistance in Western Kenya
... of drug resistance is not well ...gene mutations associated with resistance to the antimalarial drugs sulfadoxine-pyrimethamine (SP) and chloroquine (CQ) in children under the age of five ...
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Accuracy of the TRUGENE HIV 1 Genotyping Kit
... Drug resistance and poor virological responses are associated with well-characterized mutations in the viral reading frames that encode the proteins that are targeted by currently available ...
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Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer.
... vant drug resistance mutations to targeted cancer therapies, both small molecule and ...confer resistance in the clinic. Of these, the activity cutoff for protein-drug affinity compared ...
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Increased Replicative Fitness Can Lead to Decreased Drug Sensitivity of Hepatitis C Virus
... sistance mutations, a 1,000-fold decrease in MOI should have de- layed viral production in the presence of the inhibitors (5, ...with drug resistance ...
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Prevalence and trends in transmitted and acquired antiretroviral drug resistance, Washington, DC, 1999–2014
... minor mutations were avail- able for the reverse transcriptase and protease genes, and sometimes for the envelope and integrase genes, full sequences were not available, and we did not have infor- mation on which ...
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Population-based human immunodeficiency virus 1 drug resistance profiles among individuals who experienced virological failure to first-line antiretroviral therapy in Henan, China during 2010–2011
... HIV drug resistance is not constant across ...of drug resistance mutations, whereas Kaifeng was ...HIV drug resistance; however like other study had set forth, the local ...
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Genotypic resistance profiles in Chinese patients with chronic hepatitis B virus infection and the efficacy of nucleoside analog rescue therapy
... genotypic resistance testing, patients continued to receive the initial nucleoside analog treatment (LAM, ADV, ETV, or LDT) if they did not carry HBV drug resis- tance ...HBV drug resistance ...
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Association between Latent Proviral Characteristics and Immune Activation in Antiretrovirus-Treated Human Immunodeficiency Virus Type 1-Infected Adults
... of drug resistance mutations is associated with lower levels of ...of mutations conferring drug resistance was inversely correlated with levels of the proinflammatory cytokines ...
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Validation of an Oligonucleotide Ligation Assay for Quantification of Human Immunodeficiency Virus Type 1 Drug Resistant Mutants by Use of Massively Parallel Sequencing
... IV drug resistance is associated with an increased risk of ther- apeutic failure, with a decrease in therapeutic options, and transmission of HIV, including drug-resistant ...of drug-resistant ...
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