drug screen
False-Positive Tricyclic Antidepressant Drug Screen Results Leading to the Diagnosis of Carbamazepine Intoxication
... toxic screen results, including certain antipsychotic medications, antihistamines, and the mus- cle relaxant ...toxic screen can still lead the clinician to the correct ...
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Generation of a drug resistance profile by quantitation of mdr 1/P glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen
... Anticancer Drug Screen of the National Cancer Institute uses 60 cell lines to identify new ...putative drug targets, and genes involved in the cell cycle and ...
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An automated semi quantitative broad drug screen in whole blood
... 9.3.1.2 Estimation of the Concentration in Blood of Identified Drugs Data in Table 9.2 compare the drug concentrations estimated by the automated drug screening procedure Sections 8.3.3.[r] ...
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Current drug use and lack of HIV virologic suppression: point of care urine drug screen versus self report
... current drug use was very common among this group of HIV-infected, predominantly ART- treated participants recruited during clinical visits and thus engaged in care to some ...Current drug use was ...
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Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen
... to screen the Prestwick Chemical Library for potential ...identify drug-candidates in a small compound library and in accurately replicating the FRDA pathogenesis in a long-term controlled cellular ...
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An automated semi quantitative broad drug screen in whole blood
... The data shown in Section B.3.2.1 suggest that n-alkanes and drugs were best chromatographed following splitless injection on the wider bore column, as gas flow through the injector at t[r] ...
259
A high-throughput drug combination screen identifies an anti-glioma synergism between TH588 and PI3K inhibitors
... the drug screen- ing, six compounds that significantly enhanced the anti- glioma effect of BKM120 in the PTEN-deficient GBM cell line were successfully identified, and the MTH1 inhibitor TH588, which had ...
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Ischemic Cerebrovasular Accident, Uncontrolled Seizures and Acute Myocardial Infarction Associated with Synthetic Marijuana Abuse
... Last time he was admitted to the hospital for seizures, while admitted he developed pressure like chest pain subsequently he was found to have elevated Troponin I with EKG changes. A diagnosis of Acute MI was made. Given ...
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Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma
... siRNA screen of the druggable genome combined with a small molecule screen of 465 compounds targeting 39 different mechanisms of actions in four NB cell ...the drug screen, aurora kinase ...
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Substance use and inhalation injury in adult burn patients: retrospective study of the impact on outcomes
... Primary outcomes measured were intubation rate de- fined as no intubation (observed with no signs of airway compromise or respiratory distress) or intubation (intu- bated prior to hospital arrival, loss of consciousness, ...
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Clinical Use of Extended-Release Injectable Naltrexone in Treating Opioid Use Disorder
... Contraindicated in patients who are engaged in current opioid use (as indicated by self- report or a positive urine drug screen) or who are on buprenorphine or methadone maintenance therapy, as well as in ...
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A Predominant Evaluation of Viable Templates for Asthma Therapy Exerting an In silico Analog Method, Virtual Library Screening
... evaluate drug likeness and describes molecular properties important for a drug’s pharmacokinetics in the human body, including their absorption, distribution, metabolism, and excretion ...active drug has no ...
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Journal of Applied Pharmaceutical Science
... The drug discovery process is not a predefined series of ...target-based drug discovery in which researchers need to survey proteins like never ...in drug discovery process and there are long ...
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TonB dependent receptor repertoire of pseudomonas aeruginosa for uptake of siderophore drug conjugates
... Two TonB-dependent receptors (TBDRs), PiuA and PirA, have been shown to be responsible for the uptake of BAL30072, MC-1, and cefiderocol in P. aeruginosa (5, 16, 17). We previously observed that some P. aeruginosa ...
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Application of Fragment-Based Drug Discovery to Membrane Proteins: Identification of Ligands of the Integral Membrane Enzyme DsbB
... however, include two components, the surfactant and the protein itself, both of which must remain stable in order to ensure proper ligand screening. Preliminary studies of DsbB/DPC and OmpA/DPC clearly demonstrated that ...
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Alcohol, drug and related health and wellbeing issues among young people completing an online screen
... reported drug problems, with 29% reporting high risk use and 44% likely drug dependence (Table ...weekly drug use was highly prevalent with 58% using alcohol, 57% tobacco, 37% cannabis, 30% ...
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Ball_unc_0153D_17195.pdf
... the drug exposure risk are neither clearly available in the literature for each drug gene pair, nor in our data sets, nor analytically straightforward to ...
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Privileged Structures and Polypharmacology within and between Protein Families.
... in drug discovery is essential to improve the efficiency of compound development and decrease drug ...phenotypic screen, we have demonstrated that binding site pocket similarity analysis can be a ...
13
Evaluation of Fluoromycobacteriophages for Detecting Drug Resistance in Mycobacterium tuberculosis
... detecting drug-resistant strains of Mycobacterium tuberculosis that uses a TM4 mycobacteriophage phAE87::hsp60-EGFP (EGFP-phage) engineered to contain the gene encoding enhanced green fluorescent protein ...
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Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance
... Our screen identified several known JmjC demethylase inhibitors, as well as new inhibitor ...the screen, validating the capability of our screening methods to identify inhibitors of ...
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