Drug Targeting
DENDRIMER CHEMISTRY AND HOST GUEST INTERACTIONS FOR DRUG TARGETING
... ABSTRACT: The objective of this review was to bring a chemicophysical approach towards dendrimers in different aspects including host-guest interaction and drug targeting. These nanosized polymeric ...
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Resealed Erythrocytes: A Novel Carrier for Drug Targeting
... vitro targeting of erythrocytes to cytotoxic T-cells by coupling of ...for targeting organs outside the RES include the preparation of carrier erythrocytes fused to thermoresponsive liposomes and their ...
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Resealed Erythrocytes: As a Carrier for Drug Targeting
... the drug targeting among Which cellular carrier offer a greater potential advantages related to its biodegradability, non pathogenicity, non-immunogenicity, biocompatibility, self degradability along with ...
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Organelle targeting: third level of drug targeting
... Abstract: Drug discovery and drug delivery are two main aspects for treatment of a variety of ...systemic drug administration is the lack of target-specific affinity toward a pathological site, ...
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INSIGHTS ON DRUG TARGETING OF TOXOPLASMA GONDII HOST INVASION PROTEINS: A REVIEW
... ROPs are secreted by the bulb region of rhoptry organelle of apicomplexans during the host invasion. These proteins are sequentially secreted after the RON proteins during the invasion process [64]. The ROP proteins ...
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LIVER SPECIFIC DRUG TARGETING STRATEGIES: A REVIEW
... : Drug delivery to liver is one of the most challenging research areas in pharmaceutical ...active targeting by surface modifications of nanoparticles with specific ligands such as carbohydrates, peptides, ...
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COLON SPECIFIC DELIVERY SYSTEM: THE LOCAL DRUG TARGETING
... specific drug delivery system, colon has a large amount of lymphoma tissue (facilitates direct absorption into blood), negligible brush border membrane activity, and much less pancreatic enzyme activity as ...
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Chemotherapeutic drug targeting to lungs by way of microspheres after intravenous administration
... the drug content in the formulation was recorded as 74% ± ...vitro drug release studies revealed that ...5-FU drug (89.2% of the drug released in the first 30 minutes), ...the drug in ...
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Nanomedicine for drug targeting: strategies beyond the enhanced permeability and retention effect
... antibody targeting is that nontargeted antibodies serving as a control to assess the effect of antibody conjugation on biodistribution and pharmacokinetics are often not ...of targeting is related to the ...
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Resealed erythrocytes: An engineering approach for drug delivery and drug targeting
... features, drug loading technology and biomedical application of resealed ...These drug carriers are rapidly taken up from blood by macrophages of reticuloendothelial system (RES) present in liver, lung and ...
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Apoptosis and cancer drug targeting
... Targeting the core apoptotic machinery is bound to be a tricky business. Successful therapies will need to intervene very precisely in the pathway to avoid unre- stricted cell killing. Direct activation of caspase ...
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Design and Characterization of Dual Drug Loaded Microspheres for Colon Drug Targeting
... % drug entrapment and swelling ...prevent drug release in the ...percent drug release of mesalamine and prednisolone from formulation in pH ...
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SLN BRAIN TARGETING DRUG DELIVERY FOR CNS: A NOVEL APPROACH
... and drug targeting system for lipophilic antitumor drugs, reduces dose so decrease in adverse ...in targeting of chemotherapy in mitosis when drug concentrations in tumour tissue were required ...
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Gemcitabine loaded vesicular drug delivery system for targeting
... anticancer drug approved for the treatment of pancreatic, non-small-cell lung, breast, and ovarian ...the drug in the ...the drug from the extracellular environment by means of a lipid ...the ...
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IN SILICO HERBAL BIOPROSPECTION TARGETING MULTI- DRUG RESISTANT MYCOBACTERIUM TUBERCULOSIS .......
... by targeting different physiological elements (Acyl-Co-A, Salicylate synthase, Ag-85, RNA binding protein and Transcription regulator) with major phytoconstituents of the selected ...herbal drug development ...
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A Novel Tumor Targeting Drug Carrier for Optical Imaging and Therapy
... a drug carrier, HSA by itself does not have targeting specificity to, ...of targeting tumors, we generated a recombinant HSA fused with a tumor targeting peptide, ATF, at its N-terminus ...
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HCS strategy targeting dysregulation of the VHL/HIF pathway for drug discovery
... preclinical drug candidates further fuelled technology ...the drug development process and is today considered a main- stream technology in the pharmaceutical industry ...ticular drug discovery or ...
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Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system
... loaded NPs were prepared using the solvent emulsification method. The surface properties, cytotoxicity, cellular uptake, cell mineralization, bone targeting potential, and animal pharma- codynamics of the TC–PLGA ...
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Active targeting of nanoparticles: An innovative technology for drug delivery in cancer therapeutics
... Focusing on cancer, applied nanotechnology has been revolutionized in the field of cancer therapeutics with immense potential owing to recent advancements in nanoparticles (NPs) based drug delivery systems. The ...
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Antibody drug conjugate targeting CD46 eliminates multiple myeloma cells
... ADC generation and characterization. MMAF was conjugated to anti-CD46 IgG1 via an mcvcpab linker (29). To create the mcvcpab linker, N-ε-maleimidocaproyloxysuccinimide ester (Pierce) was dis- solved in anhydrous ...
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