Drug targets
Identification of potential drug targets by subtractive genome analysis of <em>Escherichia coli</em> O157:H7: an in silico approach
... Additionally, we also identified that a single unique pro- tein can also take part in multiple pathways. Proteins that are involved in more than one pathway could be more effective drug targets when, in ...
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Insilico Molecular Characterization of Potential Drug Targets in Oral Cancer
... Abstract: Oral cancer is the most frequent type of cancer occurring in India. It has ranked in top three types of cancer in the country. Most oral cancers occur as squamous cell carcinomas (SCCs) and many OSCCs develop ...
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Choosing anticancer drug targets in the postgenomic era
... potential drug targets that are geneti- cally validated in the sense that they are recurrently altered in tumors and play a causal role in maintenance of the malignant ...potential targets, both ...
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A comprehensive map of molecular drug targets.
... mechanism-based drug discovery depends on the definition of the drug ...link drug response to genetic variation, understand stratified clinical efficacy and safety, rationalize the differences ...
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Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening
... bithionol drug targets is shown in ...of drug, followed by proteolysis. Drug binding peptides are essentially “protected” against proteolysis, and after gel electrophoresis they have higher ...
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CRIMALDDI: platform technologies and novel anti malarial drug targets
... novel drug targets to be ...multiple targets, even though the mechanisms of differentiation are still not fully ...a drug whose effect is not cura- tive but would be used in asymptomatic ...
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Nuclear receptors: emerging drug targets for parasitic diseases
... Nuclear receptors are promising drug targets for treating parasitic diseases. They have been found in all parasitic helminths studied and, like their counterparts in higher animals, they control essen- tial ...
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PROTEIN PHOSPHATASES-OCCURRENCE, CLASSIFICATION AND AS DRUG TARGETS IN HUMAN DISEASES
... PKases have become increasingly popular drug targets, constituting 30% of several pharmaceutical manufacturers’ drug discovery programs. The approval of rapamycin for immune suppression, imatinib for ...
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Recent Methods in Identifying Drug Targets using Insilico Methods
... different targets, sinsce cell surface receptor is recognized as perfect focus for some drug ...two targets with the end goal that the free vitality of the general framework is ...
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A Review Article on Hyperlipidemia: Types, Treatments and New Drug Targets
... Hyperlipidemia is a medical condition characterized by an increase in one or more of the plasma lipids, including triglycerides, cholesterol, cholesterol esters, phospholipids and or plasma lipoproteins including very ...
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Homology Modeling and Molecular Drug Design Approach in Identifying Drug Targets of TIGR4 in Streptococcus pneumonia
... the drug candidates. Hence, these proteins can be considered as the drug targets and the above mentioned ligands having higher dock score may be considered as the drug ...
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Histamine and migraine revisited: mechanisms and possible drug targets
... antihistaminic action and a drug used in Meniere’s disease was tested in migraine prophylaxis. Two open label trials, one with 80 participants and another with 60 tried out cinnarizine in doses up to 75 mg daily ...
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Motif mediated protein-protein interactions as drug targets
... Integrins are heterodimer receptors that are crucial in cell-adhesion, providing signalling into the cell in case of proper adhesion. Among other processes they play a key role in the angiogenesis and metastasis of solid ...
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Drug targets and predictive biomarkers in the management of metastatic melanoma
... At present, vemurafenib is the only approved therapy that specifically targets an aberrant molecule in melanocytes. However the field is rapidly expanding, and many newer molecules are likely to be approved in the ...
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Anticancer drug targets: cell cycle and checkpoint control
... various targets such as ATM and chk1, may emerge as a new class that can enhance cyto- toxic responses to existing chemotherapy ...intended targets in ...
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Anticancer drug targets: approaching angiogenesis
... In addition to the therapeutic targets described above, interventions at other stages of the angiogenic process are being explored. The realizations that vessel disassembly is required for the initiation of ...
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Depression: Current Therapy and ovel Anti-depressant Drug Targets
... in drug discovery and development, a substantial increase in the efficacy of antidepressant therapies has not been achieved, although improvements in safety and tolerability have been observed in newer drug ...
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Anticancer drug targets: growth factors and growth factor signaling
... Signaling pathways are initiated with the binding of a ligand, such as PDGF, EGF, EGF-like ligands (e.g., TGF-α and amphiregulin), or IGF, to its cognate transmembrane receptor (1). Ligand binding induces the ...
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Adipokines as Drug Targets in Diabetes and Underlying Disturbances
... interesting drug target to treat autoimmune diseases, obesity, insulin resistance, and adipose tissue ...to drug development in several immune-mediated ...
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Molecular Evolution: HIV Drug Targets and Resistance
... drugs have been developed and approved for use by HIV- infected individuals. These drugs are often taken as a cocktail, different types of inhibitors taken at the same time. A typical cocktail or drug combination ...
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