Dry Powder Inhalers
Investigation of electrostatic charging phenomena in dry powder inhalers and the effect on deposition
... dose inhalers (pMDIs), dry powder inhalers (DPI), and nebulizers, each class with its unique strengths and ...a dry powder mix (DPI) that is fluidized when the patient ...
209
Evaluation study of dry powder inhalers: a concise, systematic review
... regarding dry powder inhalers are associated with dose-delivery, fine particle fraction content and performances at varying ...or powder formulation, or both combined for achieving optimal ...
6
In vitro dose comparison of Respimat<sup>®</sup> inhaler with dry powder inhalers for COPD maintenance therapy
... tested dry powder inhalers delivered a smaller percentage of the modeled mDTL of the API than the Respimat inhaler when relating to the ND as given by the label claim (Figure ...
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Satisfaction, preference and error occurrence of three dry powder inhalers as assessed by a cohort naïve to inhaler operation
... Subjects and methods: One hundred and thirty healthy Hong Kong Chinese subjects aged $40 years without a previous diagnosis of COPD and asthma and with no experience of using dry powder inhalers ...
15
Delivery characteristics and patients’ handling of two single-dose dry-powder inhalers used in COPD
... single-dose dry powder inhalers (Breezhaler and HandiHaler) were evaluated in two complementary ...the inhalers with placebo capsules by 82 patients with mild to severe ...the inhalers ...
11
Patients’ usability of seven most used dry-powder inhalers in COPD
... seven Dry Powder Inhalers (DPIs) indicated as appropriate in COPD was tested and compared: Breezhaler, Diskus, Ellipta, Genuair, Nexthaler, Spiromax, and ...
9
Particle size measurement of lactose for dry powder inhalers
... involves the measurement of “a representative sample, dispersed at an adequate concentration in a suitable liquid or gas”. For the measurement the powder is passing a laser beam. The light of the laser beam is ...
6
Correct usage, ease of use, and preference of two dry powder inhalers in patients with COPD: analysis of five phase III, randomized trials
... Handheld inhalers are used to deliver treatment for ...multiple inhalers may reduce patient compliance. The Anoro Ellipta™ dry powder inhaler (DPI) simultaneously delivers umeclidinium bromide ...
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Particle engineering of materials for oral inhalation by dry powder inhalers I Particles of sugar excipients (trehalose and raffinose) for protein delivery
... The pulmonary route of delivery offers a potential alternative to parenteral administration of peptides and proteins. Protection of protein structure is essential in both processing and storage of the final formulation. ...
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Comparison of serious inhaler technique errors made by device-naïve patients using three different dry powder inhalers: a randomised, crossover, open-label study
... reliable inhalers that are associated with a reduced risk of serious errors, as com- pared with current commonly used inhalers, are needed to improve effective use, adherence, and disease control [1, 5, 7, ...
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Differences in health care outcomes between postdischarge COPD patients treated with inhaled corticosteroid/long-acting β<sub>2</sub>-agonist via dry-powder inhalers and pressurized metered-dose inhalers
... of inhalers such as a soft-mist inhaler. Inclusion of soft-mist inhalers would have complicated the analysis by both adding another device type and requiring inclusion of monotherapy combinations due to the ...
14
Comparison of peak inspiratory flow rate via the Breezhaler®, Ellipta® and HandiHaler® dry powder inhalers in patients with moderate to very severe COPD: a randomized cross-over trial
... The inhalers were characterized be- fore the start of the study to ensure a specific pressure drop and the airflow through the device was comparable before and after attaching the ...
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Asthma control in patients receiving inhaled corticosteroid and long acting beta2 agonist fixed combinations A real life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation
... Results: 111 patients were analyzed: 53 (47.7%) received maintenance therapy of extrafine beclomethasone- formoterol (BDP/F) pressurized metered dose inhaler (pMDI), 25 (22.5%) fluticasone-salmeterol (FP/S) dry ...
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Asthma control in patients receiving inhaled corticosteroid and long-acting beta2-agonist fixed combinations. A real-life study comparing dry powder inhalers and a pressurized metered dose inhaler extrafine formulation
... Results: 111 patients were analyzed: 53 (47.7%) received maintenance therapy of extrafine beclomethasone- formoterol (BDP/F) pressurized metered dose inhaler (pMDI), 25 (22.5%) fluticasone-salmeterol (FP/S) dry ...
8
Systematic review of the dry powder inhalers colistimethate sodium and tobramycin in cystic fibrosis
... of dry powder formulations and is thought to generally reduce over time with improved technique, and may be controlled with the use of bronchodilators, to some extent, in some ...
11
Drug Delivery to the Respiratory Tract Using Dry Powder Inhalers
... drug powder should have a narrow particle size distribution and a mean particle size of 5 µm with nearly no particles larger than 10 ...drug powder. For a good dry powder inhaler (DPI) ...
230
Dry-powder inhalers in patients with persistent airflow limitation: usability and preference
... More than 50 % of patients who tested all devices preferred the Genuair and perceived this device as the easiest to use, the nurse ’ s judgement confirming their opinion (Fig. 1, where t[r] ...
9
Particle engineering of materials for oral inhalation by dry powder inhalers II Sodium cromoglicate
... geometric diameters greater than 5 m could be deposited in the lungs. These authors purported a two-fold advantage for large porous particles. The first proposed advantage was that, as a consequence of their large size ...
48
Appropriate use of a dry powder inhaler based on inhalation flow pattern
... Inhalation with an optimal flow pattern is mandatory for effective use of dry powder inhalers (DPIs). The ISAM (International Society of Aerosol in Medicine)/ERS (European Respiratory Society) task ...
7
Need of education for dry powder inhaler storage and retention – a patient-reported survey
... The DPIs available today have differences in shelf-life, time in-use and storage conditions such as protection against humidity (Table 1). In Norway, the drug reim- bursement for chronic diseases allows prescription cov- ...
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