Dual targeting
Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy
... of dual-targeting grafted ...for dual-epitope insertion because the larger number of loops and loops of different sizes offer greater scope for epitope insertion compared to ...potent ...
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Dual-targeting of aberrant glucose metabolism in glioblastoma
... That both glycolysis and mitochondrial oxidative phos- phorylation (OXPHOS) play key roles in cancer cells has led to a new research focus into drugs that inhibit both pathways [7,9,10]. Dichloroacetate (DCA), a pyruvate ...
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Angiopep-2-conjugated poly(ethylene glycol)-<em>co</em>-poly(ε-caprolactone) polymersomes for dual-targeting drug delivery to glioma in rats
... a dual-targeting drug delivery system involving Angiopep-2-conjugated biodegradable polymersomes loaded with doxorubicin (Ang- PS-DOX) was developed to exploit transport by the low-density lipoprotein ...
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Dual targeting of the thioredoxin and glutathione systems in cancer and HIV
... The net cellular effects of ROS and RNS are coordinated by systems that generate these reactive species (NADPH oxidases and NO synthases), consume them (antioxidant systems), or reverse the protein modifications that ...
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Dual Targeting of Acute Leukemia and Supporting Niche by CXCR4-Directed Theranostics
... indirect targeting of the interaction of leukemic cells with cellular components of the BM microenvironment represents an attractive strategy to induce the best possible remission before immunological ...
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Beta Lactam Estrogen Receptor Antagonists and a Dual Targeting Estrogen Receptor/Tubulin Ligand
... We focused our further efforts on the development of a dual ligand for ER and tubulin. It is known that a trimethoxyaryl ring, found in the natural products colchicine and combretastatin A-4 as well as in ...
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Dual targeting of tumour cells and host endothelial cells by novel microtubule targeting agents, pyrrolo 1,5 benzoxazepines
... Progression to apoptosis induced by PBOXs in PC3 cells seemed to follow patterns previously observed in other cell types including CML K562 cells, HeLa cells and A2780 cells which also e[r] ...
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Dual targeting of CCR2 and CX3CR1 in an arterial injury model of vascular inflammation
... We have also shown that blocking CCR2 with this low molecular weight antagonist ameliorates the inflamma- tory response to vascular injury. This finding is consis- tent with previous results using a CCR2 antibody in a ...
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Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors.
... apoptosis. Dual blockade of both RTKs promotes cytotoxicity across all drug doses tested in A204 and G402 ...a dual PDGFR a and FGFR1 inhibitor, induces apoptosis in MRT cells as a single ...or dual ...
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Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer
... Figure 9 summarizes our results demonstrating multi-faceted targeting of the AR and mTORC1 axis by sub-micro molar salinomycin. Inhibition of AR Ser-81 phosphorylation -- a modification that promotes AR’s ...
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Enhanced blood-brain-barrier penetrability and tumor-targeting efficiency by peptide-functionalized poly(amidoamine) dendrimer for the therapy of gliomas
... The dual-targeting dendrimer exhibited outstanding BBB penetrability and glioma targeting efficiency both in vitro and in vivo, which strikingly enhanced the anti-gliomas effect of the drugs and ...
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A novel double-targeted nondrug delivery system for targeting cancer stem cells
... The targeting activity of DCLK1–HA–PEG–PLGA NPs to CSCs in vitro and in vivo was ...the dual-targeting NPs we synthesized were able to effectively target ...
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Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles
... Incubation of M21 and U-87 MG cells with RhB- NoTarget-LP resulted in no detectable liposome-to-cell association, and no binding was found for any RhB-LNP with the negative control cell line L-929. The most pronounced ...
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Novel Dual Mitochondrial and CD44 Receptor Targeting Nanoparticles for Redox Stimuli Triggered Release
... receptor dual-targeting redox-sensitive multifunctional nanoparticles (micelles) based on oligomeric hyaluronic acid (oHA) were ...receptor targeting oHA worked as a hydrophilic shell, and the ...
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Chlamydomonas Immunophilins and Parvulins: Survey and Critical Assessment of Gene Models
... Of particular interest are three complex Chlamydomonas cyclophilins with no orthologues in Arabidopsis. CYN52 and -53 have two cyclophilin domains in tandem, a feature not hitherto found in any other organism. ...
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Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors
... novel dual inhibition mechanism targeting CoV main protease (M pro ) from feline infectious peritonitis virus (FIPV), which leads to lethal systemic granulomatous ...
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A Smart Targeting System for Online Advertising
... advertisements targeting technology, it can improve the efficiency of the online advertisements platform, make visitors become buyers, save the cost of advertisers and improve customer’s ...
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Targeting T<sub>1</sub> and T<sub>2</sub> dual modality enhanced magnetic resonance imaging of tumor vascular endothelial cells based on peptides-conjugated manganese ferrite nanomicelles
... prognosis. Targeting T 1 /T 2 dual modality magnetic resonance (MR) imaging of the tumor vascular endothelial cells (TVECs) with MR molecular probes can greatly improve diagnostic sensitivity and ...
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Distinct subpopulations of FOXD1 stroma derived cells regulate renal erythropoietin
... expressed β-subunit, HIF-β, which is also known as the aryl hydro- carbon receptor nuclear translocator (ARNT). Together with HIF-1, HIF-2 regulates a multitude of hypoxia responses that allow cells to adapt to and ...
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Mapping Sentinel Lymph Node Metastasis by Dual-probe Optical Imaging
... developed dual-tracer optical imaging to combine lymphatic mapping agents and tumor targeting agents, with the aim to provide a real-time and accurate evaluation of ...tumor targeting agents, the ...
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