e1a protein
In Vivo Association of Adenovirus Large E1A Protein with the Human Mediator Complex in Adenovirus-Infected and -Transformed Cells
... large E1A protein activates transcription from early viral promoters by a mechanism that requires a forty amino acid zinc finger activation domain in E1A conserved region 3 ...the E1A-CR3 zinc ...
8
Repression in vitro, by human adenovirus E1A protein domains, of basal or Tat-activated transcription of the human immunodeficiency virus type 1 long terminal repeat.
... how E1A represses transcription from the HIV LTR, we developed an in vitro transcription system in which the HIV LTR is activated by the HIV-1 Tat protein (36) and is repressed by specific Ad E1A ...
5
Adenovirus E1A protein activates transcription of the E1A gene subsequent to transcription complex formation.
... Infection with an E1A- virus, followed 6 h later by superinfection with a wild-type virus, led to to preferential transcriptional activation of the ElA gene of the first virus, suggestin[r] ...
8
Transcription stimulation of the adenovirus type 12 E1a gene in vitro by the 266-amino-acid E1A protein.
... 8 5056-5062 Copyright © 1994, American Society for Microbiology Transcription Stimulation of the Adenovirus Type 12 Ela Gene In Vitro by the 266-Amino-Acid ElA Protein HITOSHI KAWAMURA,'[r] ...
7
Characterization of the 55-Residue Protein Encoded by the 9S E1A mRNA of Species C Adenovirus
... the E1A transcript generates mRNAs encoding multiple E1A pro- ...(55R) E1A protein, which is encoded by the 9S mRNA, is particularly interesting due to the unique proper- ties it displays ...
12
Mouse Adenovirus Type 1 Early Region 1A Effects on the Blood-Brain Barrier
... 1A protein E1A, we inves- tigated whether the activity of this known viral transcriptional regulator is needed for BBB disruption and other phenotypes associated with ...and E1A mutant virus caused ...
12
Mouse Adenovirus Type 1 Early Region 1A Is Dispensable for Growth in Cultured Fibroblasts
... hAd E1A was its ability to transactivate other early adenovirus promoters, such as E1B, E2, and E3 (7, ...MAV-1 E1A may also have the ability to transactivate MAV-1 early ...Using E1A viral mutants, ...
7
Characterization of an E1A-CBP Interaction Defines a Novel Transcriptional Adapter Motif (TRAM) in CBP/p300
... Since E1A, p53, E2F, and TFIIB all recognize the same small motif within CBP, we wondered whether or not these proteins might have common sequences that facilitate the rec- ognition of the CBP ...12 E1A ...
8
Adenovirus Transforming Protein E1A Induces c-Myc in Quiescent Cells by a Novel Mechanism
... of E1A to p300 most likely interferes in the formation or the stability of the ternary com- plex consisting of p300, YY1, and HDAC3 in ...YY1 protein in cell extracts prepared following virus infection ...
13
Generation of a Conditionally Replicating Adenovirus Based on Targeted Destruction of E1A mRNA by a Cell Type-Specific MicroRNA
... of E1A may be explained by the results of previous studies that have reported the capacity of adenovirus to replicate normally despite strongly reduced levels of E1A ...reduce E1A protein ...
7
Mimicry of Cellular A Kinase-Anchoring Proteins Is a Conserved and Critical Function of E1A across Various Human Adenovirus Species
... that E1A itself is not causing aberrant interactions between PKA subunits ...of E1A did not inhibit the association between regulatory and catalytic PKA components (consistent with what we know of where ...
21
Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter.
... mutant E1A proteins (5), the Gal4 derivative Gal-C13Xoff (which contains AR1) activates the wild-type E4 promoter more efficiently than mu- tant Gal-C13Doff (which lacks AR sequences) ...of E1A genes (5), ...
8
Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells
... to E1A should lead to recruitment of E1A to Tcf-regulated promoters in cells containing stabilized β-catenin (Figure ...fusion protein to the Tcf sites in the ...13S E1A cDNAs in order to ...
14
The Cellular Protein Complex Associated with a Transforming Region of E1A Contains c-MYC
... larger protein complex consisting of TRRAP and p400 (also known as the Tip60 complex) ...in E1A-mediated transformation remains to be ...of E1A, suggesting that the activity may be independent of the ...
10
Adenovirus Type 5 E1A and E6 Proteins of Low-Risk Cutaneous Beta-Human Papillomaviruses Suppress Cell Transformation through Interaction with FOXK1/K2 Transcription Factors
... in E1A. To map the E1A sequences involved in in- teraction with the newly identified E1A-interacting proteins, we infected HeLa cells with a large panel of previously char- acterized Adv5 mutants ...
13
In Vivo Potential Effects of Adenovirus Type 5 E1A and E1B on Lung Carcinogenesis and Lymphoproliferative Inflammation
... which E1A 243-aa protein was preferentially expressed at moderate or low levels ...expressing E1A 243-aa protein was assessed dynamically by immunostaining of lung sections with ...
7
Distinct domains of adenovirus E1A interact with specific cellular factors to differentially modulate human immunodeficiency virus transcription.
... of E1A to bind p300 and to immortalize cells, E1A-mediated repression of cellular genes seems likely to play an important role in cell transfor- mation and ...its protein-protein interactions ...
9
pRB-E2F1 Complexes Are Resistant to Adenovirus E1A-Mediated Disruption
... GST-E1A is unable to disrupt pRB-E2F1 complexes. Based on evidence that pRB uses two distinct interaction mechanisms to contact E2F transcription factors (7, 10, 24), we sought to investigate how E1A ...
10
Cellular GCN5 Is a Novel Regulator of Human Adenovirus E1A-Conserved Region 3 Transactivation
... increased protein acetylation is associated with transcriptional re- pression, including the mouse mammary tumor virus promoter (19, 43, ...by E1A could acetylate factors such as CDK9 and reduce phos- ...
12
Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.
... 12 0022-538X/93/127556-05$02.00/0 Copyright © 1993, American Society for Microbiology Adenovirus E4orf4 Protein Binds to Protein Phosphatase 2A, and the Complex Down Regulates ElA-Enhanc[r] ...
5