E3 ligases
Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling
... Display E3 Ligase Activity and Promote Degradation of ...functional E3 ligases, pu- rified MBP:BTSL1c or MBP:BTSL2c were incubated with E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme ...
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Evaluating downstream targets of cullin4-dependent E3 ligases and of D-type cyclins: implications for the dysregulation of ubiquitination and cell growth in cancer
... have reinforced this idea, and established the CUL4 DDB1 ligase as an important regulator of proliferation and development. The CUL4 DDB1 ligase plays a role in replication licensing by regulating CDT1 levels during the ...
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Atlas on substrate recognition subunits of CRL2 E3 ligases
... HIF-α in renal carcinoma, the CRL2-mediated degradation pathways of the remaining SRSs and their substrates are also functioning in other diseases. Among them, the polyubiquitination and degradation of VEGF inhibits the ...
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The Specificities of Kaposi's Sarcoma-Associated Herpesvirus-Encoded E3 Ubiquitin Ligases Are Determined by the Positions of Lysine or Cysteine Residues within the Intracytoplasmic Domains of Their Targets
... E3 ligases are frequently viewed as molecular scaffolds that catalyze ubiquitination by bringing the substrate and E2 within close ...an E3-ubiquitin ligase, by binding to a particu- lar protein ...
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Ubiquitination and deubiquitination emerge as players in idiopathic pulmonary fibrosis pathogenesis and treatment
... ubiquitin E3 ligases and DUBs responsible for turnover of most key proteins in pulmonary fibrosis have been relatively ...specific E3 ligases and DUBs involved in fibrosis is critical because ...
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RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases.
... U-box E3 ligases, such as human Ark2C and ...the E3 ligase activity of RavN in a variety of assays (Fig 4), consistent with their importance for E2-ubiquitin ...
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Roles of Ubiquitination and SUMOylation in DNA Damage Response
... SUMO E3 ligases. The E3-ligating enzymes improve conjugation by either recognizing target lysines or enhancing SUMO discharge from the E2 to the ...many E3 ubiquitin ...SUMO E3 enzymes ...
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Regulation of cell fate determination by Skp1 Cullin1 F box (SCF) E3 ubiquitin ligases
... is triggered only following phosphorylation at multiple sites (Ye et al., 2004). Binding partners increase or inhibit the activity of SCF complexes and in particular binding or covalent modification of the C-terminal ...
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Regulation and Modulation of Human DNA Polymerase δ Activity and Function
... Keywords: DNA polymerase δ ; PDIP46; poldip3; PDIP38; poldip2; DNA replication; enzyme regulation; DNA damage response; p12 subunit; E3 ligases; cell cycle.. Introduction.[r] ...
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Signaling-mediated control of ubiquitin ligases in endocytosis
... recruit E3 ligases to ...the E3 ligase murine double minute (MDM2), an important negative regulator of p53, is critical for rapid receptor internalization ...
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The Poxviral RING Protein p28 Is a Ubiquitin Ligase That Targets Ubiquitin to Viral Replication Factories
... The colocalization of ubiquitin with p28 in virus factories could be the consequence of p28-mediated ubiquitination of poxviral or host proteins in this compartment; however, colo- calization occurred independent of a ...
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Review Article New insights into regulation of p53 protein degradation
... critical E3 ubiquitin ligase for p53. Recent studies shown a number of E3 ligases have been documented for p53, including Pirh2, COP1, TRIM24, ARF-BP1, CA- RP1/2, TOPORS, Synoviolin, CHIP, JFK, ...
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Following Ariadne's thread: a new perspective on RBR ubiquitin ligases
... canonical E3 RING domains: complexes of UbcH7 and RING1s can be identified by pull-down and co-immunoprecipitation experiments ...RBR ligases recognize and bind substrates? Substrate binding has been ...
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The Molecular Basis of Substrate Recognition by the Family of Pellino E3 Ubiquitin Ligases
... the E3 ubiquitin ligase tumor necrosis factor receptor associated factor 6 (TRAF6); this modification prevents TRAF6 association with IRF7, which ultimately suppresses the TLR3-induction of type I interferon ...
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E3 ubiquitin ligases and their control of T cell autoreactivity
... Ubiquitin is a highly conserved 76 amino acid globular protein that is attached to substrate proteins to modify a variety of cellular processes. Although first described as a mechanism for proteolysis of misfolded or ...
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Ubc13: the Lys63 ubiquitin chain building machine
... possible E3 ligases can bind the E2~Ub complex to recruit the charged E2 to the protein ...The E3 is not only a recruitment factor but plays an important role in stimulating the catalytic activity of ...
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The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research
... Targeting the ubiquitin-proteasome pathway is a new concept in therapy for many human diseases, particularly cancer and inflammatory-related diseases. Two different proteasome inhibitors entered clinical trails for the ...
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Linked Tumor-Selective Virus Replication and Transgene Expression from E3-Containing Oncolytic Adenoviruses
... adenoviral E3 region was found to be nonessential for viral replication in ...the E3 region into oncolytic adenoviruses has been found to positively influence antitumor efficacy in preclinical models and ...
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A Pre-Immediate-Early Role for Tegument ICP0 in the Proteasome-Dependent Entry of Herpes Simplex Virus
... Herpes simplex virus (HSV) entry requires host cell 26S proteasomal degradation activity at a postpenetra- tion step. When expressed in the infected cell, the HSV immediate-early protein ICP0 has E3 ubiquitin ...
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Transcription Factors in Muscle Atrophy Caused by Blocked Neuromuscular Transmission and Muscle Unloading In Rats
... The muscle wasting associated with long-term intensive care unit (ICU) treatment has a negative effect on muscle function re- sulting in prolonged periods of rehabilitation and a decreased quality of life. To identify ...
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