E5 protein
Endoplasmic Reticulum-Localized Human Papillomavirus Type 16 E5 Protein Alters Endosomal pH but Not trans-Golgi pH
... HPV-16 E5 protein to the endoplasmic reticulum of foreskin keratinocytes (HFK) ...HPV-16 E5 can alkalinize endosomes (52, 56), we were unable to find significant amounts of E5 associated with ...
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Artificial Transmembrane Oncoproteins Smaller than the Bovine Papillomavirus E5 Protein Redefine Sequence Requirements for Activation of the Platelet-Derived Growth Factor β Receptor
... one protein from single transcripts, build capsids from repeating subunits, harness cel- lular mechanisms to produce viral products, and express ex- tremely small ...SH protein of parainfluenza virus 5, ...
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The first hydrophobic region of the HPV16 E5 protein determines protein cellular location and facilitates anchorage independent growth
... 16 E5 protein (HPV16 E5) is 83 amino acids in length and contains three well-defined hydrophobic ...The protein is expressed at very limited amounts in transfected cells and the absence of ...
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The Bovine Papillomavirus E5 Protein Requires a Juxtamembrane Negative Charge for Activation of the Platelet-Derived Growth Factor β Receptor and Transformation of C127 Cells
... papillomavirus E5 gene encodes a 44-amino-acid, homodimeric transmembrane protein that is the smallest known transforming ...The E5 protein transforms cultured fibroblasts by forming a stable ...
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Human Papillomavirus Type 16 E5 Protein as a Therapeutic Target
... The E5 protein has transforming activity in HPV-16 infected ...the protein-encoding regions, E6 and E7 ORFs are considered to play major roles in HPV ...The protein encoded by L1 is highly ...
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The Human Papillomavirus Type 16 E5 Protein Impairs TRAIL- and FasL-Mediated Apoptosis in HaCaT Cells by Different Mechanisms
... (HPV-16) E5 protein on apoptosis was investigated by using the polyclonal HaCaT-cell lines stably transfected either with E5 (HaCaT/E5) or the empty vector (HaCaT/ pMSG) as ...the ...
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The E5 protein of the human papillomavirus type 16 down regulates HLA I surface expression in calnexin expressing but not in calnexin deficient cells
... HPV16 E5 could be organized as a transmembrane protein with three putative transmem- brane helices ...this E5 gene, selectively targeting local hydrophobicity and propensity towards helix ...
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Human Papillomavirus Type 16 E5 Protein Induces Expression of Beta Interferon through Interferon Regulatory Factor 1 in Human Keratinocytes
... tween E5 expression, IRF-1, and IFN signature stimulation in the unique model of HPV16-related cervical squamous carcinogene- sis W12 cells ...of E5 protein on IFN expression in the natural context ...
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Productive Interaction between Transmembrane Mutants of the Bovine Papillomavirus E5 Protein and the Platelet-Derived Growth Factor β Receptor
... mutant E5 protein in transformed C127 cells, we cloned the E5-L24A mutant into RVY-tet, a self-contained doxycycline-repressible retrovirus vector (un- published ...regulated E5-L24A ...
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The Canine Papillomavirus E5 Protein Signals from the Endoplasmic Reticulum
... CfPV2 E5 is localized in ER membranes. The 83-amino-acid HPV-16 E5 protein resides predominantly in ER membranes, whereas the smaller 44-amino-acid BPV-1 E5 protein resides in membranes ...
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Cytotoxic T-Lymphocyte Responses to Human Papillomavirus Type 16 E5 and E7 Proteins and HLA-A*0201-Restricted T-Cell Peptides in Cervical Cancer Patients
... HPV-16 E5 protein by T2 cell-binding ...HPV-16 E5 for sequences fitting the allele-specific motifs of the human MHC-I molecules of ...potential E5-specific HLA-A*0201 binding peptides were ...
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Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.
... wild-type E5 protein or a transformation-competent mutant results in tyrosine phosphorylation of the PDGF re- ceptor and in the formation of an E5-PDGF receptor ...transformation-defective E5 ...
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Human papillomavirus type 16 E5 protein affects cell-cell communication in an epithelial cell line.
... of E5 on connexin transcrip- tion was ...versus E5-expressing cells, suggesting that E5 has no major influence on the transcriptional control of connexins (results not ...Cx43 protein, which ...
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Cytotoxic-T-Lymphocyte Human Papillomavirus Type 16 E5 Peptide with CpG-Oligodeoxynucleotide Can Eliminate Tumor Growth in C57BL/6 Mice
... oncogenes: E5, E6, and E7 (26, 66). E5, E6, and E7 are unique tumor antigens and may serve as ideal materials to be used as a tumor ...of E5 protein explored its potential as a tumor antigen ...
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Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein.
... the E5 protein were not definitive for several ...the E5 protein (12, ...the E5 protein and the PDGF b receptor was assessed in COS monkey epithelial cells engi- neered to ...
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Bap31 Is a Novel Target of the Human Papillomavirus E5 Protein
... that E5 may contribute to this ...HPV16 E5 protein has been shown to protect HaCaT keratinocytes from both Fas- and TRAIL-mediated apoptosis, a process also influenced by Bap31 (27, ...that E5 ...
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Quantitative Role of the Human Papillomavirus Type 16 E5 Gene during the Productive Stage of the Viral Life Cycle
... HPV16 E5 is contributing to the productive stage of the viral life cycle is not yet ...HPV16 E5 protein and the EGFR signaling ...EGF, E5-expressing cells display anchorage- independent growth ...
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Multiple Transmembrane Amino Acid Requirements Suggest a Highly Specific Interaction between the Bovine Papillomavirus E5 Oncoprotein and the Platelet-Derived Growth Factor Beta Receptor
... the E5 protein, we constructed a variety of additional receptor chimeras and mu- tants, which are depicted in ...the E5 protein after stable coexpression with E5 in Ba/F3 cells, a ...
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Crystallography in Spaces E2, E3, E4, E5 … Study of Three Crystal Families of Space E5
... We have succeeded to finish the study of all the crystal families thanks to the encouragements, the help and the collaboration on our research team of teachers or students. Some of them are dead as E. F. Bertaut, D. ...
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The bovine papillomavirus type 4 E8 protein binds to ductin and causes loss of gap junctional intercellular communication in primary fibroblasts.
... structural protein. It is interesting that HPV-16 E5, which previously had been shown to bind to ductin (6), when ex- pressed in the established cell line HaCaT also inhibits GJIC and does so to an extent ...
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