EAE, experimental autoimmune encephalomyelitis
<p>Protective Effects of Leukadherin1 in a Rat Model of Targeted Experimental Autoimmune Encephalomyelitis (EAE): Possible Role of P47phox and MDA Downregulation</p>
... targeted experimental autoimmune encephalomyelitis (EAE) through focal injection of inflammatory cytokines to the spinal ...presented EAE clinical signs, and their behaviors were ...
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Schubart, Anna (2002): Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE). Dissertation, LMU München: Fakultät für Biologie
... of experimental autoimmune encephalomyelitis (EAE), an animal model of MS initiated by an autoimmune response to CNS myelin ...of EAE, in which demyelination is antibody mediated ...
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Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE)
... Although EAE is canonic- ally not thought of as a PNS disease, the presence of the typical “MS-miR-signature” indicates that female DRGs may be affected concordantly with CNS ...
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Effects of Bu Shen Yi Sui Capsule on Th17/Treg cytokines in C57BL/6 mice with experimental autoimmune encephalomyelitis
... sclerosis; EAE: Experimental autoimmune encephalomyelitis; TGF: Transforming growth factor; ROR: Retinoic acid-related orphan receptor; FoxP3: Forkhead box P3; PA: Prednisone acetate; TCM: ...
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Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker
... albumin; EAE: experimental autoimmune encephalomyelitis; GAPDH: glyceraldehydes-3- phosphate dehydrogenase; GLK: germinal center kinase-like kinase; HC: healthy control; IL: interleukin; IQ: ...
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IL 23 produced by CNS resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
... imental autoimmune encephalomyelitis (EAE), it has now been reported by a number of laboratories that IL-12 is not essential in the development of EAE or of a number of other inflammatory ...
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Neuroimmune interaction between multiple sclerosis and inflammatory bowel disease
... As experimental autoimmune encephalomyelitis (EAE) studies have shown Multiple Sclerosis is a TH1 CD4+ cells mediated disease, the immunologic cascade starts with the activation of the innate ...
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Humoral response in experimental autoimmune encephalomyelitis targets neural precursor cells in the central nervous system of naive rodents
... in EAE mice and demonstrated bands corresponding to yet unidentified NPC surface ...of EAE-AS in the subventricular zone in all age groups compared to NAIVE-AS ( p < ...the EAE humoral response ...
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Transgenic inhibition of astroglial NF-κB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis
... with experimental autoimmune encephalomyelitis (EAE), a model of MS, have shown that ON is accompanied by presence of macrophages [7] and T cells [8] in the optic nerve, and strategies aimed ...
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... investigated. Experimental autoimmune encephalomyelitis (EAE), an in vivo model of MS, was induced in female C57BL/6 mice by immunization with myelin oligodendrocyte glycoprotein ...
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Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis
... of experimental autoimmune encephalomyelitis (EAE), an animal model of MS, are significantly more severe than in wild-type mice with ...limiting autoimmune brain inflamma- tion, which ...
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Original Article Cytoprotective effects of high dose of -galactosylceramide against activation-induced CD4+ T and CD8+ T cell death as an adjuvant
... Methods: Experimental autoimmune encephalomyelitis (EAE) was induced using adoptive transfer of MOGCD4+ cells treated using α-GC into recipient C57BL/6 mice while the MOGCD4+ cells treated ...
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Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
... stress. For example, it is under these conditions that sPLA2 may exert the most profound effects on the activity of cytosolic PLA2 (cPLA2 [32]). The specific involvement of cPLA2 in EAE has also been demonstrated ...
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Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high dose cytoreductive treatment followed by syngeneic bone marrow transplantation
... immunosuppressive regimens (cyclophosphamide [CY] 300 mg/kg or total body irradiation [TBI] 900 cGy) followed by syngeneic bone marrow transplantation (SBMT) in prevention and treatment of already established ...
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Compensatory Neuroprotective Response of Thioredoxin Reductase Against Oxidative-Nitrosative Stress Induced by Experimental Autoimmune Encephalomyelitis in Rats: Modulation by Theta Burst Stimulation
... early occurrence in EAE lesions. Also, macrophages and microglia influence metabolic and regenerative processes, striping myelin and inducing matrix metalloproteinases. The localization of mitochondria within ...
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Immunosuppressive activity of 13 cis retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats
... achieved in vivo, further suggesting that the prevention of EAE was due to a suppressive activity on T cell-mediated immunity. The immunosuppressive activity of 13-cRA included suppression of interleukin 2, whose ...
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Multiple sclerosis
... an autoimmune, at times demyelinating, disease in mammals with immunization of CNS myelin (experimental autoimmune encephalomyelitis, or EAE), first made by Thomas Rivers at the ...
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“Microglial nodules” and “newly forming lesions” may be a Janus face of early MS lesions; implications from virus-induced demyelination, the Inside-Out model
... anti-myelin autoimmune cells generated in the periphery, while the Inside-Out model refers to a primary CNS axonal degeneration and subsequent re- cruitment of systemic/adaptive immune ...an autoimmune ...
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MicroRNA control in the development of systemic autoimmunity
... Innate immune cells express Toll-like receptors (TLRs), which function as sensors of infectious microbes [9]. Th eir signaling results in the transcriptional regulation of many immuno-modulatory genes that instruct the ...
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Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination
... Demyelination was similarly induced in NOD-Scid/J im- munodeficient mice that lack T and B cells. We observed that the type I IFN receptor is required for anti-MOG + C-mediated demyelination. Remarkably, there was no ef- ...
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