Effector mechanisms
IL 13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation
... Genetic factors are known to strongly influence susceptibility to allergic inflammation. The Th2 cytokine IL-13 is a central mediator of allergy and asthma, and common single-nucleotide polymorphisms in IL13 are ...
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In Depth Analysis of the Interaction of HIV 1 with Cellular microRNA Biogenesis and Effector Mechanisms
... ABSTRACT The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in ...
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Effector mechanisms of interleukin 17 in collagen induced arthritis in the absence of interferon γ and counteraction by interferon γ
... Introduction Interleukin (IL)-17 is a pro-inflammatory cytokine in rheumatoid arthritis (RA) and collagen-induced arthritis (CIA). Since interferon (IFN)-γ inhibits Th17 cell development, IFN-γ receptor knockout (IFN-γR ...
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T cell effector mechanisms in experimental autoimmune uveitis (EAU)
... It has been shown that administration of TGF-p can prevent the occurence of some autoimmune diseases [Johns et al., 1991; Kuruvilla et al., 1991; Racke et al., 1991]. As the clearance of circulating active TGF-p is very ...
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Effector mechanisms in organ specific autoimmunity I Characterization of a CD8+ T cell line that mediates murine interstitial nephritis
... investigate mechanisms of cell-mediated tissue destruction in an organ-specific autoimmune disease, we have established and characterized a nephritogenic CD8+ T cell ...antigen-specific effector T cell ...
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Effector mechanisms in Graft-vs-Host Disease in response to minor Histocompatibility antigens. I. Absence of correlation with cytotoxic effector cells.
... To test the possibility that the failure to detect antihost Tc cells shortly after grafting as observed in several patients might reflect a general Tc cell impairment (as a result of inc[r] ...
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The effect of a high ambient temperature on the physiological responses of Friesian and Brahman x Friesian calves fed on two rations : a thesis presented in partial fulfilment of the rquirements for the degree of Master of Agricultural Science in Animal Science at Massey University
... effector mechanisms for the regulation of body temPerature involve 1 changes in the metabolic rate heat production; 2 changes in peripheral blood flow; 3 changes in evaporative heat loss[r] ...
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PubMedCentral-PMC5605299.pdf
... Latently human immunodeficiency virus (HIV)-infected cells are transcriptionally quiescent and invisible to clearance by the immune system. To demonstrate that the latency reversing agent vorinostat (VOR) induces a window ...
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Cellular stress responses to chronic heat shock and shell damage in temperate Mya truncata
... immune effector mechanisms, for example the GO cellular process melanosome 3 days after damage (FDR = ...an effector mechanism in bivalve immunity (Luna-Acosta et ...
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Plasmodium infection alters Anopheles gambiae detoxification gene expression.
... triggers effector mechanisms like melanization [1], and a burst of expression of genes encoding consti- tuents of the immune system including the production of free radicals [12] that needs a counter ...
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Activation of Natural Killer (NK) T Cells during Murine Cytomegalovirus Infection Enhances the Antiviral Response Mediated by NK Cells
... specific effector mechanisms, namely perforin and IFN-␥, in the antiviral response by utilizing gene-targeted ...molecular effector systems were unable to mount a complete ␣-GalCer-induced antiviral ...
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Nervous Control of the Salivary Glands of the Carnivorous Mollusc Philine Aperta
... Properties of some gastropod salivary effector neurones Philine Effector neurone projections to salivary nerve Gland cell response to effector neurone stimulation Electrical coupling bet[r] ...
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Binding of urate and caffeine to haemocyanin analysed by isothermal titration calorimetry
... the effector- induced changes in the oxygen-binding properties of the respiratory ...of effector binding, employing ultracentrifugation techniques and equilibrium dialysis, have been carried ...either ...
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The ADP Ribosyltransferase Domain of the Effector Protein ExoS Inhibits Phagocytosis of Pseudomonas aeruginosa during Pneumonia
... This effector protein is a bifunctional toxin, with distinct domains for GTPase-activating protein (GAP) and ADP-ribosyltransferase (ADPRT) activities. The GAP domain targets Rho GTPases (12), whereas the ADPRT ...
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Structurally Steady Control of Tumor Cell Populations
... In the case of model system (2), we could construct the Lyapunov function and identify the region of stability in terms of model parameters. In physical terms, this means that the parameter controlling tumor growth ...
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Herpes Simplex Virus Is Equipped with RNA- and Protein-Based Mechanisms To Repress Expression of ATRX, an Effector of Intrinsic Immunity
... additional mechanisms by which HSV-1 regulates ...the mechanisms for the loss of ATRX protein, we treated uninfected or infected HEK-293 cells with an inhibitor of protein synthesis (cycloheximide [CHX]) or ...
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Mechanisms of antibody dependent cellular cytotoxicity: the use of effector cells from chronic granulomatous disease patients as investigative probes
... leukocyte effector cells (neutrophils, lymphocytes, and monocytes) from normal subjects and from chronic granulomatous disease (CGD) ...CGD effector cells when phagocytosis was inhibited by the addition of ...
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Diverse Evolutionary Mechanisms Shape the Type III Effector Virulence Factor Repertoire in the Plant Pathogen Pseudomonas syringae
... III effector gene’s function or its interaction would expect to find that many of these effector proteins with the host recognition ...III effector genes in a variety of ...III effector genes ...
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Effect of curcumin on mycobacterium tuberculosis infection
... various mechanisms for its anti tubercular actions are the enhancement of apoptosis and autophagy of macrophages, harbouring tubercular bacilli, blocking of human Kv ...
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Kennedy Institute of Rheumatology Division, Imperial College London, 12–13 November 2003: Towards a molecular toolkit for studying lymphocyte function in inflammatory arthritis
... Tissue-specific ‘address codes’ have been defined for skin and gut homing lymphocytes by using the pattern of chemokine receptors and adhesion molecules that they express. Isolating specific microvascular vessels has ...
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