effector protein
Analysis of Vir protein translocation from Agrobacterium tumefaciens using Saccharomyces cerevisiae as a model: evidence for transport of a novel effector protein VirE3
... virulence protein VirE3. Although the function of this protein is still an enigma, it is worth noting that this protein has been conserved in all the different types of Ti and Ri ...transported ...
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Effector Protein Cig2 Decreases Host Tolerance of Infection by Directing Constitutive Fusion of Autophagosomes with the Coxiella Containing Vacuole
... Cig2 effector protein was necessary for con- tinued fusion of autophagosomes with the lysosome-derived vac- uole in which ...transport protein that promotes fusion of autophagosomes with ...
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Immunodominant Regions of a Chlamydia trachomatis Type III Secretion Effector Protein, Tarp
... secretion effector protein called Tarp and that immunization with Tarp induces protection against challenge infection in ...Tarp protein by expressing 11 fragments of Tarp as glutathione ...
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The Campylobacter jejuniCiaD effector protein activates MAP kinase signaling pathways and is required for the development of disease
... Acute inflammation caused by C. jejuni or other invasive enteric pathogens, such as Shigella spp. and Salmonella enterica serotype Typhimurium (S. Typhimurium), is asso- ciated with extensive epithelial injury and ...
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Application of phiLOV2.1 as a fluorescent marker for visualization of Agrobacterium effector protein translocation
... other effector proteins (VirE2, VirE3, VirD5 and VirF) into the host ...translocated effector proteins inside the host cell, several studies were conducted to visualize the translocated effector ...
35
The ADP Ribosyltransferase Domain of the Effector Protein ExoS Inhibits Phagocytosis of Pseudomonas aeruginosa during Pneumonia
... This effector protein is a bifunctional toxin, with distinct domains for GTPase-activating protein (GAP) and ADP-ribosyltransferase (ADPRT) ...
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Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c di GMP Effector Protein
... binding protein permanently localized to the membrane while retaining its activity for holdfast ...mutant protein lacking two central arginine residues within this region failed to efficiently bind c-di-GMP ...
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A Novel Legionella Genomic Island Encodes a Copper Responsive Regulatory System and a Single Icm/Dot Effector Protein Transcriptionally Activated by Copper
... L egionella pneumophila is an intracellular human pathogen that multiplies within alveolar macrophages and causes a severe pneumonia known as Legionnaires’ disease (1–3). In the environment, L. pneumophila thrives in ...
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Fuchs, Evelyn (2008): Regulation of Membrane Traffic at the Golgi Apparatus by Rab GTPases and their GAPs. Dissertation, LMU München: Fakultät für Biologie
... inhibit protein synthesis in target ...its effector protein Golgin-97 (Lu et ...its effector proteins (White et ...inhibits protein synthesis by inactivating the ...
139
Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori
... (T4SS) effector protein CagA into polarized epithelial cells, but did not affect IL-8 chemokine production or the secretion of vacuolat- ing cytotoxin VacA and γ-glutamyl-transpeptidase ...
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Original Article RNA-binding protein RBM38 acts as a tumor suppressor in gastric cancer
... RBM38 effector protein in gastric cancer and adjacent normal gastric specimens, and analyzed its expression level with the cli- nicopathological ...RBM38 protein was also associated with poor ...
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Multiple Roles of Ypd1 Phosphotransfer Protein in Viability, Stress Response, and Virulence Factor Regulation in Cryptococcus neoformans
... an effector protein with a DNA-binding domain to modulate the expression levels of target genes, whereas the multicom- ponent phosphorelay system is often connected to an addi- tional signaling cascade, ...
5
MicroRNAs in apoptosis, autophagy and necroptosis
... domain-containing protein (FADD) and ...downstream effector caspases (caspase-3, 6 and 7) to directly induce cell demise or cleaves the Bcl-2 family member Bid to form tBid, thereby triggering the ...
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An HIV Envelope gp120-Fc Fusion Protein Elicits Effector Antibody Responses in Rhesus Macaques
... fusion protein and further improve immune ...fusion protein containing HIV p24 Gag linked to mouse Fc (35) was extraordinarily potent for eliciting cellular or antibody ...
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Pattis, Isabelle (2007): Molekulare Mechanismen der Erkennung des CagA-Proteins als Substrat für das Cag-Typ IV-Sekretionssystem in Helicobacter pylori. Dissertation, LMU München: Fakultät für Biologie
... Diese ausgewählten Kandidaten für Effektorproteine wurden zunächst mit Hilfe des GSK-Phosphorylierungsassays auf Translokation in Epithelzellen überprüft. Dazu wurden mit dem GSK-Expressionsvektor N-terminale Fusionen ...
168
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
... the protein kinase inhibitor dasatinib (Axon Medchem) at a final concentration of 50 nM for 30 min- utes at 37°C to enhance the detection of low-avidity T cells (8, 56) and CCR7 BV421 monoclonal antibody (clone ...
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Role of the Ebolavirus Glycoprotein in Countering Tetherin During Viral Budding
... characterized. Here we describe sequences within the EboGP ectodomain and membrane spanning domain (msd) as necessary to relieve tetherin restriction of viral particle budding. Fusing the EboGP msd to a normally secreted ...
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The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum
... Functional domain analysis of RARP-2. ARP effector domain architectures fre- quently coexist with various functional modules. RARP-2 might act similarly to other known microbial ARPs that use the ankyrin repeats ...
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Adapters in lymphocyte signaling
... In order to exert their effector functions, lymphocytes need to be activated. This process requires at least two stimuli, a primary stimulus, which is mediated via an immunoreceptor (e.g., the T cell receptor ...
10
Original Article LATS2-mediated YAP1 phosphorylation is involved in HCC tumorigenesis
... arrest at the G1/S and G2/M phase via inhibit- ing CDK2 activity and Cdc2-Cyclin B kinase activity, respectively [27, 28]. Moreover, Dysregulation of LATS2 expression has been reported to involve in tumorigenesis by ...
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