Efflux Pump
Emergence of a Potent Multidrug Efflux Pump Variant That Enhances Campylobacter Resistance to Multiple Antibiotics
... tidrug efflux pump CmeABC is the predominant efflux system and plays a key role in mediating resistance to structurally diverse antimicrobials ...powerful efflux system is regulated primarily ...
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Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa
... Efflux pump inhibitor activity of conessine in ...OprM efflux, this study determined whether conessine enhanced antibacterial activity against wild-type, MexAB- OprM overexpressed, and MexB deletion ...
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Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics
... as efflux pump inhibitors can be of great importance in two diversified directions but ending to one single outcome, ...block efflux pumps still needs to be ...
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Development of an accumulation assay and evaluation of the effects of efflux pump inhibitors on the retention of chlorhexidine digluconate in Pseudomonas aeruginosa and Staphylococcus aureus
... standard efflux pump inhibitors, either CCCP or reserpine was studied using the protocol developed based on the procedure out- lined by Mortimer and Piddock ...
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Synthesis and Characterization of Piperine Analogs as Potent Staphylococcus aureus NorA Efflux Pump Inhibitors
... The prepared analogs 5, 6 and 7a-e were bio evaluated for their potentiation of the anti infective activity of ciprofloxacin in Staphylococcus aureus 1199B over expressing the targeted Nor A efflux pump ...
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Identification and Assessment of Fluroquinolone Multidrug Efflux Pump in Multidrug Resistant Staphylococcus aureus isolated from Hospital Wastewater in Kuala Lumpur
... MDR efflux pump genes used in this study are selected based on their frequent occurrence in phenotypically resistant ...NorA efflux pump. NorA efflux pump is one of the most ...
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A Pseudomonas putida efflux pump acts on short-chain alcohols
... bacterial efflux pumps acting on biofuels returned no candidates for the short-chain alcohols n-butanol and isobutanol ...identify efflux pumps for biofuels [19, 20], this led to the assumption that ...
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IDENTIFICATION OF AN EFFLUX PUMP GENE, NORA, IN METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN BAGHDAD
... First recognized in 1960, methicillin-resistant Staphylococcus aureus (MRSA) was considered to be a medical oddity. Now, MRSA is the most common nosocomial bacterial pathogen isolated in many parts of the world ...
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Efficacy of "HLE"—a multidrug efflux-pump inhibitor—as a disinfectant against surface bacteria
... to efflux pumps revealed only the presence of efrA and efrB in all bacteria; however, norE and mexD genes were detected in some strains (norE gene was detected in all bacteria except ...of ...
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The Effect of Thyme (Thymus vulgaris) Extract on the Expression of norA Efflux Pump Gene in Clinical Strains of Staphylococcus aureus
... NorA efflux pump considered as one of the contributors to antibiotic resistance in Staphylococcus aureus ...NorA efflux pump in ciprofloxacin-resistant strains of ...norA efflux ...
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Correlation between resistance of Pseudomonas aeruginosa to benzalkonium chloride and expression of efflux pump genes
... PCR amplification of the efflux pump regulatory genes (MexR, NfxB, MexT, and MexZ) was performed using primers shown in Table 1 (Linares et al., 2005). The PCR mixture containing 100 ng of chromosomal DNA, ...
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SYNERGISTIC AND EFFLUX PUMP INHIBITORY ACTIVITY OF PLANT EXTRACTS AND ANTIBIOTICS ON STAPHYLOCOCCUS AUREUS STRAINS
... for efflux pump inhibitory activity. Berberine is an efflux pump substrate and inhibits growth of bacteria in the presence of efflux pump inhibitor and hence acts as a marker to ...
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Effect of Mutation in Efflux Pump Regulatory Protein (MexR) of Pseudomonas aeruginosa: A Bioinformatic Study
... properties and function. Hence, the use of bioinformatics tools has received considerable interest in recent years since they can predict the consequence of changes in normal protein, and contribute to drug design and ...
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Phytochemical Composition and Anti-Efflux Pump Activity of Hydroalcoholic, Aqueous, and Hexane Extracts of Artemisia tournefortiana in Ciprofloxacin-Resistant Strains of Salmonella enterica Serotype Enteritidis
... Cartwheel method was used for phenotypic de- tection of the efflux pump in S. enteritidis isolates. Briefly, ciprofloxacin-resistant and intermediate S. enteritidis strains were cultured in 5 ml of ap- ...
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Original Article Molecular epidemiology and its risk factors for efflux pump gene expression of multi-drug resistant pseudomonas aeruginosa isolated from ICU patients
... of efflux pump gene of MDRPA strain were demonstrated in our present ...three efflux pump ...positive/high efflux pump gene expression of multi-drug resistant pa ...
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EFFLUX PUMP INHIBITORS: ENHANCE THERAPY AND CAUTERIZE TUBERCULOSIS
... an efflux of various anti TB drugs from the infected bacterial cell, resultant decreasing the intracellular drug in the bacterial ...Mycobacterial efflux pumps may have originally served to protect against ...
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The ABC Type Efflux Pump MacAB Protects Salmonella enterica serovar Typhimurium from Oxidative Stress
... multidrug efflux pump MacAB is known to be required for Salmonella enterica serovar Typhimu- rium virulence after oral infection in mice, yet the function of this pump during infection is ...this ...
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The nature and epidemiology of OqxAB, a multidrug efflux pump
... OqxAB efflux pump have been extensively ...stream efflux pump operon oqxAB and acrAB ...AcrAB efflux pump was regulated by RamA and SoxS, and the outer membrane protein TolC was ...
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Efflux Pump Inhibitors Derived From Natural Sources as Novel Antibacterial Agents Against Pseudomonas aeruginosa: A Review
... it is better to use the genotypic test along with phenotypic tests to study the expression of efflux pump genes in P. aeruginosa. It has been proven that molecular methods are the only ways to survey the ...
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Determination of imipenem efflux-mediated resistance in Acinetobacter spp., using an efflux pump inhibitor
... transmitters. Efflux pumps usually act synergistically with decreasing the per- meability of the outer membrane, which leads to removing antibacterial agents ...(8). Efflux pumps are divided into 5 families ...
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