efflux pumps
← Return to Article Details Antibiotic resistance and efflux pumps
... the efflux and entry of the drug ...quinolone efflux or modify drug ...of efflux pumps or under expression of porins, which lowers the quinolone concentration within the bacterial cell ...
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Detection of DNA Gyrase Mutation and Multidrug Efflux Pumps Hyperactivity in Ciprofloxacin Resistant Clinical Isolates of Pseudomonas aeruginosa
... to efflux pumps and topoisomerase activity, the overexpression of MexCD-OprJ and MexXY-OprM potentially re- duces the strains susceptibility to non-fluoroquino- lone antibiotics Gentamicin (Aminoglycosides) ...
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The inhibitory effect of fluphenazine decanoate and caffeine on Staphylococcus aureus efflux pumps
... belong to five family of transporter included ABC cassette superfamily which depend on ATP hydrolysis as energy source, the multidrug and toxic-compound extrusion family (MATE), resistance nodulation division superfamily ...
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Contribution of the Ade Resistance Nodulation Cell Division Type Efflux Pumps to Fitness and Pathogenesis of Acinetobacter baumannii
... played a slightly diminished growth rate (0.98 ⫾ 0.01), while the growth rates of the mutants with either adeB or adeG deleted were similar to that of the parent (Table 1), suggesting that constitutive expression of ...
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Investigating The Functional Relationships Of RND Efflux Pumps In Methicillin Resistant Staphylococcus Aureus
... RND efflux pumps in Gram-positive bacteria are more closely related to the ESH family than to the Gram-negative HAE-1 proteins (107, ...MmpL pumps abolish their function, suggesting the necessity of ...
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Detection of the Mex Efflux Pumps in Pseudomonas aeruginosa by Using a Combined Resistance Phenotypic Markers and Multiplex RT PCR
... clinically-important efflux pumps in the Re- sistance-Nodulation-Cell Division (RND) family including MexAB-OprM, MexXY, MexCD-OprJ and MexEF-OprN in Pseudomonas aeruginosa using a combination of ...
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Mechanisms Efflux Pumps of Acinetobacter baumannii (MDR): Increasing Resistance to Antibiotics
... Natural efflux pump inhibitors (plant extracts): Biricodar and timcodar, Falvone, Berberis, Mahonia, Dalea versicolor, Lycopus europaeus, Rosmarinus officinalis, are the most common use against bacteria ...on ...
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Adaptive Resistance in Bacteria Requires Epigenetic Inheritance, Genetic Noise, and Cost of Efflux Pumps
... of efflux pumps are associated with an energetic cost that must be taken into ...the pumps are very unspecific on its substrates [21, 32, ...acrAB-tolC efflux pump, is known to recognize a ...
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Short chain diamines are the physiological substrates of PACE family efflux pumps
... Hassan, KA, Naidu, V, Edgerton, JR et al. (9 more authors) (2019) Short chain diamines are the physiological substrates of PACE family efflux pumps. Proceedings of the National Academy of Sciences of the ...
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How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps
... (MDR) efflux pumps are an important mechanism of antibiotic resistance and are required for many pathogens to cause ...measuring efflux activity can be split into two groups, (i) those that directly ...
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MDR1/P glycoprotein and MRP 1 drug efflux pumps in pancreatic carcinoma
... drug efflux pumps (MDR1 P-gp and/or MRP-1) is common in pancreatic tumours and so potentially could contribute, at least in part, to the chemoresistant biology of this ...these efflux pumps – ...
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Detection of Mex Efflux Pumps in Pseudomonas aeruginosa using a Multiplex Phenotypic and Genotypic
... Mex efflux pumps for phenotypic markers were: Carbenicillin (MexAB-OprM) (4 mg/L increase in the 8–32 mg/L), erythromycin (MexCD-OprJ), gentamicin (MexXY-OprM) ...Mex pumps including phe-arg- β- ...
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EFFLUX PUMPS: AN OVERVIEW
... Antibiotic efflux pumps appear a major component of microbial resistance to many classes of major antibiotics namely the tetracycline, the macrolides, and the ...antibiotic efflux appears sufficient ...
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An Update on Plant-Derived Compounds as Potential Inhibitors of the Bacterial Efflux Pumps: With Reference to Staphylococcus aureus and Escherichia coli
... bacterial efflux pumps are responsible for imparting resistance to many ...on Efflux Pump Inhibitors (EPI) from plant resources urges immediate ...many efflux pump inhibitors have been ...
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Metabolic Compensation of Fitness Costs Is a General Outcome for Antibiotic Resistant Pseudomonas aeruginosa Mutants Overexpressing Efflux Pumps
... using pumps collected in vesicles have shown that the constant activity of these systems may acidify the medium within the vesicle ...efflux pumps are overexpressed as a consequence of mutations in TABLE 1 ...
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<p><em>Acinetobacter baumannii</em> Efflux Pumps and Antibiotic Resistance</p>
... ux pumps could also be complicated in an early stage of infection, such as adhesion to host cells and ...ux pumps in bacteria can confer reduced susceptibility to antibiotics; however, such decreases do not ...
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Efflux Pumps Modulation in Colorectal Adenocarcinoma Cell Lines: The Role of Nuclear Medicine
... lower efflux percent- age at 20 minutes after incubation with the radiotracer, comparing to control cells ...in efflux of this radiotracer, leading to a lower reversion on the retention rate in LS1034 ...
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Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram negative pathogens
... As mentioned above the drug recognition profile of PACE pumps includes primarily synthetic biocides, most of which have only been in the environment for 50-100 years. However, genes encoding homologous PACE family ...
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Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens
... The observation that several AceI homologues can confer resistance to multiple biocides and can mediate transport of the fl uorescent substrates pro fl avine and acri fl avine led to their designation as a new family of ef ...
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Engineering microbes for tolerance to next-generation biofuels
... hydrocarbons, efflux pumps offer a promising strategy for increasing biofuel tolerance and ...production. Pumps that have been shown to be effective at improving bio- fuel tolerance are listed in ...
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