EGFR mutation
A retrospective analysis in patients with EGFR-mutant lung adenocarcinoma: is EGFR mutation associated with a higher incidence of brain metastasis?
... between EGFR mutation and the risk of BM in pulmonary adenocarcinoma ...had EGFR mutations in the entire ...with EGFR mutations both at initial diagnosis ...that EGFR mutation ...
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Patients harboring EGFR mutation after primary resistance to crizotinib and response to EGFR-tyrosine kinase inhibitor
... (EGFR) mutation with icotinib. Icotinib is a kind of EGFR-tyrosine kinase inhibitor (EGFR-TKI) that has shown effectiveness as therapy for advanced NSCLC with EGFR activating mutations, ...
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Monitoring of high-density lipoprotein cholesterol level is predictive of EGFR mutation and efficacy of EGFR-TKI in patients with advanced lung adenocarcinoma
... EGFR mutation detection was performed in all ...had EGFR mutation and received EGFR-TKIs as first-line treatment, with 70 patients treated with gefitinib (Iressa, 250 mg per day, ...
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Original Article TTF-1 and EGFR expression are related to EGFR mutation in lung adenocarcinoma
... 1). EGFR mutations in lung adenocarcinoma Overall, EGFR mutations were examined in 213 cases of lung adenocarcinoma (exons 18, 19, 20, and 21, including T790M, see Table ...of EGFR mutation in ...
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A case of EGFR mutation-positive lung adenocarcinoma in which the T790M allele fraction was increased by repeated EGFR-TKI treatment
... involves EGFR-tyrosine kinase inhibitors ...on EGFR-TKI resistance have shown that the T790M mutation within the EGFR gene is present in approximately half of the patients who develop resist- ...
5
Clinical outcomes of advanced non-small-cell lung cancer patients with EGFR mutation, ALK rearrangement and EGFR ALK co-alterations
... in EGFR phosphorylation or KIT amplification, and so on [23, 28, ...to EGFR TKI and crizotinib in EGFR/ALK co-altered patients were similar to those in typical EGFR mutation and ALK ...
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Original Article Relationship between epidermal growth factor receptor (EGFR) mutation and serum cyclooxygenase-2 Level, and the synergistic effect of celecoxib and gefitinib on EGFR expression in non-small cell lung cancer cells
... The EGFR signal transduction pathway has been a hotspot for research on cancer, lung cancer in ...of EGFR-TKIs for treating NSCLC, and reports on their efficacy ...However, EGFR-TKI efficacy is most ...
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Docetaxel for non small cell lung cancer harboring the activated EGFR mutation with T790M at initial presentation
... During the clinical course of treatment for our patient, docetaxel was effective, contrary to our pretreatment expectations. To the best of our knowledge, our case is the first clinical report describing the efficacy of ...
6
Combination of EGFR-TKIs with chemotherapy versus chemotherapy or EGFR-TKIs alone in advanced NSCLC patients with EGFR mutation
... with EGFR mutation-positive NSCLC in Tangdu Hospital (Xi’an, China) from January 2010 to December ...for EGFR mutation analysis, a diagnosis of stage IIIb or IV or recurrent NSCLC with a ...
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Clinical Effects of EGFR Inhibitors on EGFR exon19 and 21 Mutationsin Lung Cancer
... an EGFR-TKI preparation, blocks the binding site of adenosine triphosphate in cell receptors and prevents downstream signal transmission and plays an anti-tumor ...of EGFR-TKI sensitive patients and improve ...
5
<p>An <em>EGFR</em>-Amplified Cervical Squamous Cell Carcinoma Patient with Pulmonary Metastasis Benefits from Afatinib: A Case Report</p>
... EGFR mutation status which is widely used as the biomarker to predict response to anti-EGFR therapies in a variety of cancers, controversies exist regarding whether EGFR ampli fi ...
5
Original Article Epidermal growth factor receptor gene mutation status of non-small cell lung cancer in Han and ethnic minorities in the Guangxi province of China
... populations. EGFR mutation was more frequent in an older age group (>65 years) when compared to a younger age group (<65 years) among females in the Zhuang but no difference was seen in the Han ...of ...
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Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer.
... 20 EGFR insertions? Anticipating the emergence of acquired resistance, Robichaux et ...expressing EGFR L858R/T790M/C797S or EGFR exon 19 deletion/T790M/C797S triple mutants are resistant to ...
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Development of personalized treatments in lung cancer: focusing on the <em>EGFR</em> mutations and beyond
... gene mutation account for ∼40% of adenocarcinoma in East Asians and ∼15% of that in Caucasians, which makes them one of the most common molecularly defined lung cancer ...of EGFR mutation as a strong ...
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Detection of the T790M mutation of EGFR in plasma of advanced non–small cell lung cancer patients with acquired resistance to tyrosine kinase inhibitors (West Japan oncology group 8014LTR (study)
... of EGFR mutation–positive NSCLC identified by commercial assays such as Scorpion ARMS and the Cobas EGFR Mutation Test, and (ii) documented disease progression based on RECIST or worsening of ...
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Newly emergent acquired EGFR exon 18 G724S mutation after resistance of a T790M specific EGFR inhibitor osimertinib in non-small-cell lung cancer: a case report
... T790M mutation is well known as the most common mechanism for resistance to the first- and second-generation tyrosine kinase inhibitors (TKIs) for EGFR mutation in non- small-cell lung ...
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Adrenal cortical neoplasms: a study of clinicopathological features related to epidermal growth factor receptor gene status
... addition, EGFR gene mutations have been re- ported in patients with non-small-cell lung cancer, and the status of these mutations has been correlated with the clinical response to tyrosine kinase inhibitors such ...
6
Relationship between EGFR gene mutation and local metastasis of resectable lung adenocarcinoma
... with EGFR gene mutation, with significantly higher pleural and endo- bronchial metastases compared with patients without mu- ...with EGFR mutation, it is critical to select an appropriate ...
6
Surgical significance and efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in patients with primary lung adenosquamous carcinoma
... with EGFR-sensitizing mutations (TKI group) were treated with EGFR-TKIs after surgery, whereas the remaining patients ...unknown EGFR-mutation status received chemotherapy or chemoradiotherapy ...
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Effectiveness of tyrosine kinase inhibitors on uncommon E709X epidermal growth factor receptor mutations in non-small-cell lung cancer
... uncommon EGFR E709X mutations and their association with treatment of EGFR ...These EGFR mutations comprised a small but distinct proportion of the total EGFR mutations population, and are ...
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