Egr-1
High level expression of Egr 1 and Egr 1–inducible genes in mouse and human atherosclerosis
... that Egr-1 levels often exceeded the levels of constitutive genes, such as actin, and that Egr-1 transcript levels were much higher in the lesion than the adjacent ...of Egr-1– ...
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Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice
... lacked Egr-1, making it dif- ficult to assess the contribution of these two compart- ...eliminating Egr-1 in the stroma alone using an immunocompetent ...of Egr-1 in Mig ...
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A NOX2/Egr-1/Fyn pathway delineates new targets for TKI- resistant malignancies
... elevates Egr-1 expression remains unknown, ingenuity pathway analysis of TKI-resistant cell lines and blast crisis LSCs reveal a number of different pathways through which this might occur including NFκB, ...
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Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla
... Immunohistochemistry was performed on formalin fixed, paraffin embedded sections, using the avidin- biotin method, as previously described [23]. Briefly, after antigen retrieval in citric buffer, slides were incubated ...
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Egr-1 increases angiogenesis in cartilage via binding Netrin-1 receptor DCC promoter
... factor, Egr-1 regulates pro- moter activity of various ...the Egr-1 could be an upstream regulator of DCC/VEGF ...of Egr-1 in OA cartilage has been con- ...the ...
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Characterization of CD44 induction by IL 1: a critical role for Egr 1
... an Egr-1 motif at position 2 301 within the CD44 promoter since mutation of this site abolished ...induced Egr-1 expression in these ...identify Egr-1 as a critical transcription ...
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Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma
... infection EGR-1 could be detected in cells infected with the adenovirus constructs carrying the EGR-1 transgene, but not in cells infected with the control ...virus. EGR-1 ...
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Redox-sensitive transcription factors EGR-1 and SP1 IN the pathogenesis of experimental gastric ulcer
... что Egr-1 и Sp-1 регулируют транскрипцию генов, ассо- циированных с патогенезом язвенной болезни желудка (факторы роста, регуляторы клеточ- ного цикла и ...мин, 1 и 3 ...мрнк ...
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Fluid shear stress activation of egr 1 transcription in cultured human endothelial and epithelial cells is mediated via the extracellular signal related kinase 1/2 mitogen activated protein kinase pathway
... the egr-1 promoter, which is typically activated ...mouse egr-1 pro- moter (Fig. 4). Control of egr-1 promoter activity via the up- stream SREs is not solely confined to shear ...
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Transcriptional control of Flt3 ligand targeted by fluorouracil-induced Egr-1 promoter in hematopoietic damage
... Hematopoietic recovery was promoted by IR activation of FL expression. Chemotherapy-induced and target-regu- lated gene therapy is a new approach for tumor chemo- therapy and gene therapy [38]. Chemotherapeuticdrugs ...
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Original Article The cellular radiosensitivity of different adenocarcinoma cells is related to their Egr-1 expression levels
... of Egr-1 in tumor ...cytometry. Egr-1 expression level was analyzed by FQ-PCR and Western blot ...that Egr-1 basic expression levels in GLC-82, HT29 and Hela cells were ...
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Lytic HSV 1 infection induces the multifunctional transcription factor Early Growth Response 1 (EGR 1) in rabbit corneal cells
... Protein extract was subjected to 10% sodium dodecyl sulfate polyacrylamide gel electrophoresis and trans- ferred onto nitrocellulose membranes. The blots were blocked using PBS with 5% (wt/vol) non-fat dry milk and ...
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Egr 1 contributes to IL 1 mediated down regulation of peroxisome proliferator activated receptor γ expression in human osteoarthritic chondrocytes
... with 1% formalde- hyde for 10 minutes at room ...at 1 × 10 6 cells per 200 μL of SDS lysis buffer (50 mM Tris-Cl (pH ...diluted 1:10 in ChIP dilution buffer ...of 1% SDS and ...
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Cigarette smoke extract induces placental growth factor release from human bronchial epithelial cells via ROS/MAPK(ERK-1/2)/Egr-1 axis
... measure Egr-1 transcrip- tional activity following manufacturer’s ...for 1 h, blocking buffer was used to wash redundant samples; bound transcription factors in the wells were detected by rabbit ...
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M CSF neutralization and Egr 1 deficiency prevent ovariectomy induced bone loss
... protein Egr-1, is central to the mechanism by which estrogen (E2) deficiency upregulates osteo- clast (OC) ...intact Egr-1–deficient mice, a strain characterized by maximally stimulated ...
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Estrogen blocks M CSF gene expression and osteoclast formation by regulating phosphorylation of Egr 1 and its interaction with Sp 1
... Regardless of the specific mechanism, the different re- sponses to acute IL-1 and TNF stimulation between SC from E2-replete and E2-depleted mice described in this study reflect events induced by E2 depletion in ...
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Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice
... type 1 (HSV-1) infection is the most common cause of sporadic, fatal encephalitis, but current understanding of how the virus interacts with cellular factors to regulate disease progression is ...response ...
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Dußmann, Philipp (2016): Characterization of a transgenic mouse expressing the reporter gene luciferase under the control of the murine early growth response-1 promoter. Dissertation, LMU München: Medizinische Fakultät
... factor 1 (HIF-1) (Maeno, Ono et ...of Egr-1 after partial hepatectomy can, in addition to the stimulation of liver cells to proliferate, also be in part due to hypoxic conditions, an effect ...
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Original Article Tobacco smoke induces MMP-2 activation in rat aortic vascular smooth muscle cells via Egr1
... induced Egr-1 mRNA and protein expres- sion in time- and concentration-dependent manners ...of Egr-1 siRNA inhibit- ed CSE-induced Egr-1 and MMP-2 ...observed. ...
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Zinc Finger Transcription Factors as Molecular Targets for Nitric Oxide-mediated Immunosuppression: Inhibition of IL-2 Gene Expression in Murine Lymphocytes
... In conclusion, inhibition of the DNA binding activities of transcription factors such as the zinc finger proteins Spl and EGR-1 appears to be a molecular mechanism for the inhibition of [r] ...
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