eIF, eukaryotic initiation factor
Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... translation initiation have not yet been well es- tablished, and none of these proteins has been identified so ...translation initiation, which pro- ceeds in several steps and depends on at least 12 ...
6
The Heme-Regulated Eukaryotic Initiation Factor 2a (eIF-2a) Kinase: Expression and Regulation of Protein Synthesis in Human Cells in vitro During Heat-Shock and Lead Toxicity
... ethylmalemine (NEM) and oxidized glutathione (GSSG), leads to phosphorylation of a subunit of eIF-2 which results in inhibition of protein synthesis (reviewed in London et al., 1987; Chen and London, 1995; Pal et ...
6
Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway
... and eukaryotic initiation factor (eIF) 4E-binding protein-1 (4E-BP1) phosphorylation in gastrocnemius and masseter muscles (P < ...elongation factor 2 was not affected by leucine or ...
10
Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... encodes eIF(iso)4E, provides only partial complementation and the recovered yeast cells grow very slowly ...translation initiation com- plex eIF4F by impeding the binding of eIF4E to the cap struc- ture ...
11
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
... of eukaryotic initiation fac- tor (eIF) 4E activity slows G1 progression in yeast [13] and non-transformed mammalian cells ...translation initiation and is thought to function through eIF4F, a ...
12
Cowpea mosaic virus middle component RNA contains a sequence that allows internal binding of ribosomes and that requires eukaryotic initiation factor 4F for optimal translation.
... In vitro translation of both proteins directed by T7 transcripts of M-RNA was stimulated fourfold by eukaryotic initiation factor 4F eIF-4F, the cap-binding protein complex.. The ratio o[r] ...
7
Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer
... the eIF family. The eIF family represents a group of proteins that are involved in the initiation step of the protein ...the eIF family plays a unique role in the initiation process by ...
8
Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220.
... A second function of 2APro in poliovirus infection of HeLa cells is in inducing cleavage of the 220-kDa polypeptide p220 component of eukaryotic translation initiation factor eIF-4F 8, 9[r] ...
6
Cell-Type-Specific Growth Restriction of Vesicular Stomatitis Virus polR Mutants Is Linked to Defective Viral Polymerase Function
... of eukaryotic translation initiation factor 2 (eIF-2 ␣ ) was enhanced ⬃ 3-fold in polR versus wild-type virus-infected L-929 cells, but neither inhibition of host gene transcription nor ...
11
MicroRNAs from plants to animals, do they define a new messenger for communication?
... display; eIF: Eukaryotic translation initiation factor; EPDENs: Edible plant derived exosome-like nanoparticles; FSH: Follicle-stimulating hormone; GI: Gastrointestinal; GTP: Guanosine ...
21
Herpes Simplex Virus 1 Infection Activates the Endoplasmic Reticulum Resident Kinase PERK and Mediates eIF-2α Dephosphorylation by the γ134.5 Protein
... of eIF-2 ␣ by HSV is a critical step during viral ...on eIF- 2 ␣ , which inhibits viral replication (4–7, 20, ...to eIF-2 ␣ phosphorylation and, thereby, shutoff of protein ...
10
Modification of eukaryotic initiation factor 4F during infection by influenza virus.
... Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Ad infection results in a specific block in cellular protein synthesis mediated in part by a drastic reduction in the pho[r] ...
9
eIF5B increases ASAP1 expression to promote HCC proliferation and invasion
... independent early recurrence factor after primary resection in patients with HCC [19]. Then, the 220 patients with HCC were divided into 2 groups based on their overall eIF5B expression level: a high eIF5B ...
13
Revisiting an old acquaintance: role for eIF5A in diabetes
... therapeutics to protect pancreatic islets from inflammation. In this issue of the JCI, Maier and colleagues identify eukaryotic translation initiation factor 5A (eIF5A) as a critical regulator of the ...
5
Inhibition of TANK Binding Kinase 1 by Herpes Simplex Virus 1 Facilitates Productive Infection
... FIG 1 An outline of type I IFN responses. Upon virus infection, TLR3 on the endosomal membrane, RIG-I, MDA5, and DNA sensors in the cytoplasm are available to detect viral nucleic acids. These sensors transmit signals to ...
9
The IE180 Protein of Pseudorabies Virus Suppresses Phosphorylation of Translation Initiation Factor eIF2α
... FIG 4 PRV IE180-mediated suppression of eIF2 ␣ phosphorylation in ST cells. (A, B) ST cells were pretreated with thapsigargin (1 M for 1 h). Subsequently, cells were treated with cycloheximide (10 g/ l) prior to ...
6
The role of eukaryotic initiation factor 2α during the metabolic depression associated with estivation
... the initiation of translation by eIF2α in estivating organisms and provides evidence for a possible mechanism by which the rate of protein synthesis is downregulated during the metabolic depression associated with ...
9
Helper Component Proteinase of the Genus Potyvirus Is an Interaction Partner of Translation Initiation Factors eIF(iso)4E and eIF4E and Contains a 4E Binding Motif
... for eIF(iso)4E and eIF4E during the infection cycle (22, ...require eIF(iso)4E for the infection of ...or eIF(iso)4E (see, ...in eIF(iso)4E and eIF4E are required to confer recessive ...
11
Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity.
... To assay the p220-specific cleavage activity in poliovirus-infected cell extracts, each 10-pl reaction mixture contained 2 [L1 of postmitochondrial supernatant from uninfected HeLa cells[r] ...
9
Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... ~2.7 × 10 6 clones screened, 8 positive clones were iso- lated using the most stringent reporter selection. To ret- est protein-protein interaction in yeast, library plasmids were rescued and cotransformed into the AH109 ...
7