eIF2-α
Protein synthesis is lowered by 4EBP1 and eIF2 α signaling while protein degradation may be maintained in fasting, hypoxic Amazonian cichlids Astronotus ocellatus
... The Amazonian cichlid Astronotus ocellatus is highly tolerant to hypoxia, and is known to reduce its metabolic rate by reducing the activity of energetically expensive metabolic processes when oxygen is lacking in its ...
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<p>The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy</p>
... Methods and Results: DN C57BL/6 mouse model was induced by streptozotocin (150 mg/ kg) injection. The mice were administered rapamycin and puerarin, respectively, daily for up to 8 weeks. After the serum and kidney ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... that eIF2 α siRNA can inhibit autophagy acti- vation, the protein expression of LC3B and p62 after transfection with eIF2 α siRNA was detected by Western ...but eIF2 α siRNA ...
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Calreticulin and other components of endoplasmic reticulum stress in rat and human inflammatory demyelination
... p-eIF2 α was detected when EAE and saline samples were compared. CHOP and p-eIF2 α values were significantly different to those seen in IFA ...
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Neuron-specific PERK inactivation exacerbates neurodegeneration during experimental autoimmune encephalomyelitis
... the levels of p-eIF2 α and CHOP were significantly increased in neurons in the lumbar spinal cords of control EAE mice compared with those in naive mice at PID 22, but the elevated lev[r] ...
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PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons
... Taken together, our findings reveal a novel role of PERK in neurons, which is eIF2 α -independent, and suggest that the impaired working memory in forebrain-specific Perk knockout mice m[r] ...
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CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma
... In the CYT997-treated group, expression of p-PERK, p-eif2 α and CHOP was significantly increased in a concentration- and time-dependent manner (Fig. 1 CYT997 inhibited cell proliferation[r] ...
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Endoplasmic reticulum stress-mediated autophagy contributes to 5-ethylamino-9-diethylaminobenzo[a]phenoselenazinium-mediated photodynamic therapy via the PERK–eIF2α pathway
... above results, we decided to further explore the relation- ship between the PERK–eIF2 α signaling pathway and autophagy in A-431 cells. We adapted the same method as earlier while salubrinal was used to ...
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Endoplasmic reticulum stress in lung disease
... factor eIF2 α [38] (figure ...of eIF2 α ...of eIF2 α or activation of its downstream response must always imply ER stress; the specific kinase involved should be ...
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Diverse roles of endoplasmic reticulum stress sensors in bacterial infection
... 1; eIF2 α : eukaryotic translation initiation factor 2 α ; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ESAT-6: early secretory antigenic target 6; Grp94: heat shock protein 90 kDa ...
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The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model
... neurotoxicity and synaptotoxicity, including tau abnormalities, and play an initiating role in the development of AD pathology. In this study, we focused on the unclarified issue of whether the neurotoxicity of A β ...
10
PubMedCentral-PMC4848592.pdf
... phosphorylates eIF2 α in response to high levels of reactive oxygen species, linking the rate of protein synthesis to the respiratory capacity of the cell ...The eIF2 α kinase general control ...
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Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
... 2 α (eIF2 α ) was shown to enhance long-term memory and synaptic plasticity in naïve ...of eIF2 α is observed in the brains of postmortem AD ...regulating eIF2 α ...
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Ribosome profiling uncovers selective mRNA translation associated with eIF2 phosphorylation in erythroid progenitors
... to eIF2 phosphorylation in HEK293 ...of eIF2 phosphorylation, in statistical analysis and in cell types complicates comparisons between these ...to eIF2 phos- phorylation, similar to the setup in ...
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The Alpha Subunit of Eukaryotic Initiation Factor 2B (eIF2B) Is Required for eIF2-Mediated Translational Suppression of Vesicular Stomatitis Virus
... the eIF2-eIF2B checkpoint has been shown to play a vital role in controlling VSV replication, we next sought to determine whether the depletion of eIF2B ␣ would increase HeLa cell susceptibility to VSV ...
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Andes Virus Nucleocapsid Protein Interrupts Protein Kinase R Dimerization To Counteract Host Interference in Viral Protein Synthesis
... 12, 25, 48). However, the inhibition of the early interferon re- sponse does not seem to be sufficient for pathogenic hantaviruses to be human pathogens. This is supported by the observation that Tula hantavirus (TULV) ...
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Poliovirus Switches to an eIF2-Independent Mode of Translation during Infection
... of eIF2-indepen- dent initiation separate from the recently described activity of ligatin and MCT-1/DENR (16, 48), which was only functional on RNA molecules that directly place the AUG start codon in the P site ...
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Mammalian Orthoreovirus Escape from Host Translational Shutoff Correlates with Stress Granule Disruption and Is Independent of eIF2α Phosphorylation and PKR
... induces eIF2 ␣ phosphorylation via the HRI kinase (24, 27) and not PKR, 3-mediated PKR inhibi- tion would not impact eIF2 ␣ phosphorylation under these con- ...of eIF2 ␣ phosphorylation similar to ...
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Transient transcriptional events in human skeletal muscle at the outset of concentric resistance exercise training
... Following an unaccustomed bout of resistance exercise, increased heat shock.. protein binding was associated with a transient rise in transcripts linked to eIF2 and.[r] ...
53
Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells.
... The extent of phosphorylation in the intact cell of the a-subunit of eucaryotic protein synthesis initiation factor eIF2 by the kinase was determined for the first time in this type of s[r] ...
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