Elastase-induced emphysema
Severity of Elastase Induced Emphysema Is Decreased in Tumor Necrosis Factor α and Interleukin 1β Receptor Deficient Mice
... pancreatic elastase, which is cleared from the lung by 24 hours, was administered to wild-type, IL-1  type 1 receptor-deficient, double TNF- ␣ (type 1 and type 2) receptor-deficient, and combined TNF- ␣ (type 1 ...
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Role of alpha macroglobulin elastase complexes in the pathogenesis of elastase induced emphysema in hamsters
... macroglobulin-pancreatic elastase complexes were recovered from the ...with elastase, hamster plasma was allowed to interact directly with the radiolabeled elastase; alpha-macroglobulin bound much ...
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Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema
... with elastase-induced ...of emphysema without the demonstration of concomitant shifts in MHC expression toward slower isoforms were limited by the technologies then available, which did not allow the ...
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A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases
... of elastase-induced emphysema, elastase directly destroys the elastic fibers and the ECM, which in turn induces a repair process that involves recruiting inflammatory cells to the local injury ...
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Whey peptide-based enteral diet attenuated elastase-induced emphysema with increase in short chain fatty acids in mice
... an elastase-induced emphysema model, based on previously published protocol ...pancreatic elastase (PPE), freshly prepared in phosphate buffered saline (PBS), was administered intratracheally ...
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Alveolar fractal box dimension inversely correlates with mean linear intercept in mice with elastase-induced emphysema
... In preparation for instillation, mice were anesthetized with 5% isoflurane for induction, and then maintained at 3%–5% iso- flurane, with oxygen set at 0.6 L/min. Once mice were sedated, a 20 µ L ketamine/xylazine ...
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Prevention of elastase-induced emphysema in placenta growth factor knock-out mice
... ation of MLE-15 cells (a mouse pulmonary type II epithelial cell line) in a dose-dependent manner and sig- nificantly promotes cell death [13]. Findings in cell cul- ture studies are compatible with those from animals. ...
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Effect of Elastase induced Emphysema on the Force generating Ability of the Diaphragm
... corrected for increases in muscle cross-sectional area (T/cm 2 ), however, was the same in emphysematous (E) and control (C) animals. Emphysema also shifted the muscle fiber L-T curve of the diaphragm but not of a ...
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Ghrelin therapy improves lung and cardiovascular function in experimental emphysema
... In elastase-induced emphysema, ghrelin treatment decreased alveolar hyperinflation and mean linear intercept, neutrophil infiltration, and collagen fibre content in the alveolar septa and pulmonary ...
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Intratracheally administered titanium dioxide or carbon black nanoparticles do not aggravate elastase-induced pulmonary emphysema in rats
... the elastase model was appropriate for the present study for the following ...exogenous elastase into the lung exhibit lung damage consistent with emphysema, which is progressive [21], and involves ...
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Inhibition of Elastase-Pulmonary Emphysema in Dominant-Negative MafB Transgenic Mice
... The elastase-induced emphysema model is a conventional experimental emphysema ...of elastase is known to cause airspace enlargement in the lungs of experimental animals ...pulmonary ...
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Is neutrophil elastase the missing link between emphysema and fibrosis? Evidence from two mouse models
... of elastase burden by immunoelectron microscopy The immunogold method (post-embedding technique) was used to localize elastase in thin lung sections prepared for electron microscopy using anti-mouse ...
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Role of CCR5 in IFN γ–induced and cigarette smoke–induced emphysema
... is induced in the lung by an increase in proteases and/or a decrease in antiproteases ...causes emphysema via an IFN-g–dependent mechanism and that null mutations of CCR5 diminish the inflammatory and ...
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Predifferentiated amniotic fluid mesenchymal stem cells enhance lung alveolar epithelium regeneration and reverse elastase-induced pulmonary emphysema
... or induced pluripotent stem cells (iPSCs) that can be dif- ferentiated and enriched into a pure population of type II alveolar epithelial cells may be suitable for transplantation to treat lung injury [23, ...
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Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?
... smoke induced emphysema development, which suggests that the presence of B-cell infiltrates may not be a mandatory prerequisite for emphysema development in this ...smoke induced ...
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Geiger-Schredelseker, Sabine (2017): Mesenchymal stem/stromal cells engineered to express the protease inhibitor alpha-1 antitrypsin for the treatment of inflammatory lung diseases. Dissertation, LMU München: Medizinische Fakultät
... with elastase only was observed (lymphocytes: P < ...receiving elastase only for all cell ...the elastase group and the groups treated with native MSCs and AAT-MSCs, respectively, was calculated ...
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Risk factors for emphysema Cigarette smoking is associated with a reduction in the association rate constant of lung alpha 1 antitrypsin for neutrophil elastase
... respiratory tract alpha 1AT was significantly lower than that of nonsmoker alpha 1AT (6.5 +/- 0.4 X 10(6) M-1s-1 vs. 8.1 +/- 0.5 X 10(6) M-1s-1, P less than 0.01). Furthermore, the smoker lower respiratory tract alpha ...
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Cigarette smoke–induced reduction of C1q promotes emphysema
... Figure 7. Intranasal C1q attenuates cigarette smoke–induced emphysema. WT mice were exposed to cigarette smoke or air for 6 months. Intranasal (i.n.) C1q was given to smoke-exposed mice (20 μg, twice per ...
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Molecular mechanisms of skin photoaging and plant inhibitors
... collagenase, elastase, and HYAL is triggered by the high levels of reactive oxygen species (ROS) produced when the skin is exposed to excessive UV radiations leading to skin ...
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The endogenous vascular elastase that governs development and progression of monocrotaline induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin
... The Endogenous Vascular Elastase That Governs Development and Progression of Monocrotaline-induced Pulmonary Hypertension in Rats Is a Novel Enzyme Related to the Serine Proteinase Adips[r] ...
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