EML4-ALK
Targeting stemness is an effective strategy to control EML4- ALK non-small cell lung cancer cells
... The mammalian target of rapamycin (mTOR), a serine/threonine kinase existing in two functionally distinct complexes (mTORC1 and mTORC2), is commonly up-regulated in various human cancers including NSCLC [34–37]. Besides, ...
13
Case Report Long-lasting response to crizotinib in NSCLC harboring EML4-ALK fusion gene and an EGFR mutation: a case report and review of the literature
... defined ALK-positive lung cancer as a specific molecular subset of NSCLC. ALK rearrangement in patients with NSCLC exhibits distinct clinical pathological characteristics, including a younger age, light or ...
11
Identification of EML4-ALK as an alternative fusion gene in epithelioid inflammatory myofibroblastic sarcoma
... for ALK, and mostly showed a nuclear membrane staining pattern ...of EML4-ALK in the current EIMS case, as well as the RRBP1-ALK fusion in a recent report [19], justified the exclusion of ...
8
Original Article Clinical effect of crizotinib on lung cancer patients with EML4-ALK fusion gene mutation
... with EML4-ALK fusion gene mutation were collected and di- vided into the experimental group (exp group) and the control group (con group), with 24 patients in each ...with EML4-ALK fusion gene ...
7
Comparison of small biopsy specimens and surgical specimens for the detection of EGFR mutations and EML4-ALK in non-small- cell lung cancer
... VENTANA ALK IHC (D5F3) detection system is the easiest to ...sensitivity/specific ALK antibodies (D5F3) with enhanced second antibody and amplification ...the EML4-ALK protein was tested in ...
9
Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs
... the EML4-ALK gene, which occurs in approximately a third of ...primarily EML4-ALK gene amplification, mutations within the TK domain of ALK (Table 2), or sometimes both ...bypass ...
16
Dual target gene therapy to EML4-ALK NSCLC by a gold nanoshell-based system
... targeting ALK and miRNA-301 in H2228 cells. Treatment of the cells with ALK siRNA significantly down-regulated the expression of ALK and the phosphorylation level of downstream protein p-ERK in H2228 ...
13
Microtubule association of EML proteins and the EML4 ALK variant 3 oncoprotein require an N terminal trimerization domain
... between EML4 and the gene encoding anaplastic lymphoma kinase (ALK) occur in ~5% of cases of non- small cell lung cancer (NSCLC) ...the EML4-ALK fusion have been identified in NSCLC resulting ...
21
Better Selection Model for EML4 ALK Fusion Gene Test in Patients with Non Small Cell Lung Cancer
... the EML4-ALK fusion can guide the selection of treatment for patients who carry a specific ...2010-2011, EML4-ALK fusion test has been performed in Israel, mostly for wild type EGFR ...
5
<p>Elevated levels of pre-treatment lactate dehydrogenase are an unfavorable predictor factor in patients with EML4-ALK rearrangement non-small cell lung cancer treated with crizotinib</p>
... of EML4-ALK rearrangement in NSCLC patients is ...in EML4- ALK rearrangement advanced NSCLC ...with EML4-ALK rearrangement receiving treatment with ...with EML4-ALK ...
10
Clinical and epidemiological study of EGFR mutations and EML4-ALK fusion genes among Indian patients with adenocarcinoma of the lung
... patients. EML4-ALK gene fusions are present in lung adeno- carcinomas from Indian patients, and the 3% incidence of EML4-ALK gene fusion in EGFR mutation-negative cases is similar to what has ...
7
Detection of <em>EML4-ALK</em> fusion gene and features associated with <em>EGFR</em> mutations in Chinese patients with non-small-cell lung cancer
... coexisting EML4-ALK fusion genes and EGFR muta- tions; further analysis revealed that of these six patients, four were male, three had adenocarcinomas, four were in relatively early stage of disease, four ...
7
CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma
... in EML4-ALK-positive cells is ALK-dependent, and is required for the oncogenic activities of EML4-ALK in ...the ALK downstream pathways such as RAS and RAC1, resulting in ...
12
Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status
... METF is regarded as an anti-hyperglycaemic agent and developed for the treatment of type 2 diabetes. Besides its circulating insulin-lowering effects that reduce fasting blood glucose levels, basic investigations ...
14
<p>Clinicopathological and Prognostic Significance of <em>EML4-ALK</em> Rearrangement in Patients with Surgically Resected Lung Adenocarcinoma: A Propensity Score Matching Study</p>
... with EML4-ALK-positive adenocarcinomas were included, the ones with inoperable tumors harboring EML4- ALK fusion gene at advanced stages were ...assess ALK rearran- gement, as rare or ...
10
<p>Refinement of diagnosis and supporting evidence for the use of immunotherapy through sequential biopsies in a case of EML4-ALK positive lung cancer</p>
... the ALK fusion gene having also been ...positive EML4-ALK rearrangement, con fi rming the lung sarcoma- toid carcinoma and lung adenocarcinoma by ...or ALK fusion are less effective than ...
6
FINDING NEW INHIBITORS FOR EML4-ALK FUSION PROTEIN: A COMPUTATIONAL APPROACH
... of EML4-ALK consisting of amino acids from 485 – 497, specific to EML4- ALK had the prepared ligands docked into this region using standard precision Glide ...
6
Next-generation sequencing facilitates detection of the classic E13-A20 EML4-ALK fusion in an ALK-FISH/IHC inconclusive biopsy of a stage IV lung cancer patient: a case report
... performed ALK immunohistochemistry using the D5F3 clone on a BenchMark XT autostainer with the UltraView DAB de- tection ...the ALK dual color break apart probe (Zytovision, Germany) that detects ...
6
Clinical outcomes in ALK rearranged lung adenocarcinomas according to ALK fusion variants
... received ALK inhibitors as second- or further-line treatment, and the ORR to ALK inhibitors was far better than to platinum- based or pemetrexed ...of ALK phospho- rylation and signal transduction ...
10
Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1
... overall ALK-rearranged NSCLC cell lines and primary tumors intrinsically show an EMT signature, although with some degree of ...by EML4-ALK, a regulation not fully investigated in NSLCL driven by ...
15