endocytic pathway
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway
... the endocytic pathway (50, 53), EBOV GP could mediate lipid mixing in intermediate endosomes, as indicated by their Rab5 signal, in our live ...the endocytic pathway to encounter host factors ...
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Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration
... pathogenesis of AD and DS. We determined that full-length amyloid precursor protein (APP) and its b-C-terminal fragment (b-CTF) act though increased activation of Rab5 to cause enlargement of early endosomes and to ...
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Role of the Endocytic Pathway in the Counteraction of BST-2 by Human Lentiviral Pathogens
... The interferon-inducible transmembrane protein BST-2 (CD317, tetherin) restricts the release of several enveloped viruses from infected cells. BST-2 is broadly active against retroviruses, including HIV-1 and HIV-2. To ...
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Sialidase Activity of Influenza A Virus in an Endocytic Pathway Enhances Viral Replication
... the endocytic pathway rather than in the Golgi regions through the exocytic pathway, in terms of the cellular acidic ...the endocytic pathway, we determined the adsorption of the vi- ...
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Receptor-Mediated Entry by Equine Infectious Anemia Virus Utilizes a pH-Dependent Endocytic Pathway
... developed quantitative real-time PCR protocols to quantify EIAV-specific early RT products produced immediately after virus entry into target cells (33), providing a sensitive and specific assay for quantifying virus ...
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Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor
... Mop might affect EGFR trafficking either through a direct interaction or through an indirect effect on the endocytic pathway. We were unable to coimmunoprecipitate Mop with either wild-type or activated ...
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The endocytic pathway acts downstream of Oskar in Drosophila germ plasm assembly
... Cell fate is often determined by the intracellular localization of RNAs and proteins. In Drosophila oocytes, oskar ( osk ) RNA localization and the subsequent Osk synthesis at the posterior pole direct the assembly of ...
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Entry of Challenge Virus Standard (CVS) 11 into N2a cells via a clathrin mediated, cholesterol , dynamin , pH dependent endocytic pathway
... The endocytic pathways that viruses enter the host cells include clathrin-mediated, caveolae-mediated, macropi- nocytosis/phagocytosis and other mechanisms [6, ...virus endocytic pathway is not ...
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Caco-2 cell acquisition of dietary iron(III) invokes a nanoparticulate endocytic pathway
... an endocytic pathway for acquisition of dietary Fe(III) by the small intestinal epithelium, which would complement the established DMT-1 pathway for soluble ...
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Infectious Entry by Amphotropic as well as Ecotropic Murine Leukemia Viruses Occurs through an Endocytic Pathway
... of endocytic vesicles also arrest vesicular ...block endocytic acidification inhibit ...an endocytic pathway, it does not necessarily indicate a requirement for an acidic compartment during ...
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The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway
... LegK2-ARP2/3 interplay controls actin polymerization on the LCV to evade LCV-late endosome fusion. The data presented above demonstrate that LegK2 interacts with and phosphorylates two subunits of the actin filament ...
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An Abp1-Dependent Route of Endocytosis Functions when the Classical Endocytic Pathway in Yeast Is Inhibited
... of endocytic sites, while overexpression of ABP1 is lethal ...to endocytic sites, though interestingly, lack of kinase localization per se does not causes a very severe phenotype on analysis of ...
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Characterization of two protein disulphide iosmerases from the endocytic pathway of Trypanosoma brucei
... and more than 100 positive plaques were isolated and sub- jected to three additional rounds of screening to generate a collection or “mini-library” of cDNAs that potentially coded from proteins present in the ...
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The Spike Protein VP4 Defines the Endocytic Pathway Used by Rotavirus To Enter MA104 Cells
... different endocytic pathways used depending on the virus ...clathrin-mediated endocytic process, while the simian rhesus rota- virus (RRV) strain uses a poorly defined endocytic pathway that ...
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Entry of Classical Swine Fever Virus into PK-15 Cells via a pH-, Dynamin-, and Cholesterol-Dependent, Clathrin-Mediated Endocytic Pathway That Requires Rab5 and Rab7
... suggesting that viral entry required a low-pH environment. By using the specific inhibitor dynasore, or by expressing the domi- nant negative (DN) K44A mutant, we verified that dynamin is required for CSFV entry. CSFV ...
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Helicobacter pylori VacA Suppresses Lactobacillus acidophilus Induced Interferon Beta Signaling in Macrophages via Alterations in the Endocytic Pathway
... duced by H. pylori in bone marrow-derived macrophages (BMDMs). We utilized whole-genome microarray analysis to identify the cellular and molecular mechanisms involved in up- take and processing of the bacteria in ...
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Mouse Hepatitis Virus Type 2 Enters Cells through a Clathrin-Mediated Endocytic Pathway Independent of Eps15
... It is important to note that previous studies have shown that cell entry of MHV-A59 is sensitive to lysosomotropic agents (ammonium chloride and bafilomycin A1) and is likely facili- tated through the clathrin-mediated ...
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Receptor-Mediated Moloney Murine Leukemia Virus Entry Can Occur Independently of the Clathrin-Coated-Pit-Mediated Endocytic Pathway
... docytic pathway is ...rin-coated-pit-mediated endocytic pathway but the potential role of the two tyrosine-based motifs in MCAT-1 distribution or function requires further ...
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Effect of Starvation on the Endocytic Pathway in Dictyostelium Cells
... endocytic pathway. Here, we show that while the general structure of the endocytic pathway is maintained in starved cells, its dynamics rapidly slow ...the endocytic pathway is ...
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Herpes Simplex Virus Type 1 Enters Human Epidermal Keratinocytes, but Not Neurons, via a pH-Dependent Endocytic Pathway
... pH-dependent, endocytic mechanism. We investigated whether this entry pathway is used in human cell types relevant to ...low-pH, endocytic pathway that is dependent on host tyrosine ...
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