Endogenous Insulin Secretion
Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report
... dial insulin than he had secreted were needed to prevent hyperglycemia even after α-glucosidase ...of insulin or augmentation of endogenous insulin secretion, was better for ...
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Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin
... between endogenous insulin secretion and the impact of prandial exogenous insulin adminis- ...prandial insulin was greatest in those with the lowest endogenous insulin ...
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Reduced endogenous insulin secretion in diabetic patients with low titer positive antibodies against GAD
... with insulin deficiency ...an insulin-dependent state than in those who did not ...of insulin therapy prevented the progression to insu- lin-dependent stage compared with the administration of ...
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Influence of Endogenous Insulin Secretion on Splanchnic Glucose and Amino Acid Metabolism in Man
... Infusion of glucose at 25 mg/kg per min for 20 min resulted in a fivefold increase in arterial insulin levels and in reversal of splanchnic glucose balance to a net uptake. Splanchnic uptake of alanine, glycine, ...
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Mechanisms of glucagon secretion during insulin induced hypoglycemia in man Role of the beta cell and arterial hyperinsulinemia
... hyperinsulinemic-euglycemic clamp (FIRI 63 +/- 1.5 or 147 +/- 0.3 microU/ml, respectively) before hypoglycemia, the alpha cell responses to hypoglycemia were identical to those of the control study. When the ...
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Hypoglycemic Effect of Phoebe Lanceolata on Alloxan-Induced Diabetic Mice
... Alloxan produced significant increase in blood glucose level by damaging pancreatic β-cells, resulting decrease in endogenous insulin secretion, which decreases the utilizati[r] ...
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Pancreas-protective effect of rituximab for acute-onset type 1 diabetes in the honeymoon period: a case report
... Rituximab exerts its effects through the suppression of β -cell antibody production and depletion of β -cells. Xu and coworkers (7) reported that AOT1DM patients treated with rituximab showed a significant decrease in ...
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Twenty four hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects
... of endogenous insulin secretion over a 24-h period, which included three mixed meals, was evaluated in 14 normal volunteers and 15 obese ...subjects. Insulin secretory rates were calculated ...
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<p>Maturity-onset diabetes of the young (MODY): current perspectives on diagnosis and treatment</p>
... Cases of MODY are often misdiagnosed as type 1 or type 2 diabetes at presentation. 13,14,19 Accordingly, an improve- ment in diagnostic signi fi cance will require targeted selec- tion of subjects for genetic testing, ...
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24 hour glucose profiles during continuous or oscillatory insulin infusion Demonstration of the functional significance of ultradian insulin oscillations
... normal insulin secretion oscillates with periods in the ultradian 100-150-min ...oscillatory insulin delivery is more efficient in reducing blood glucose levels than continuous administration, nine ...
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Prospective randomized study for optimal insulin therapy in type 2 diabetic patients with secondary failure
... which endogenous insulin secretion is completely depleted, basal-bolus insulin therapy with an ultra rapid-acting insulin analogue represents an opti- mal therapeutic choice as it ...
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The effect of insulin administration on c-peptide in critically ill patients with type 2 diabetes
... variables: Insulin-requiring diabetes (yes vs. no), insulin administration within 24 h before admis- sion c-peptide measurement (yes ...of insulin administration on beta- cell function and ...
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POTENTIAL HERBS AGAINST DIABETES MELLITUS – AN UPDATE
... contain insulin receptors to which insulin binds ...of insulin can be altered by either a change in receptor affinity for insulin or a change in the total number of ...of insulin leads ...
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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in β cells
... glucose-stimulated insulin secretion, LDH-A overexpression resulted in stimulation of insulin secretion even at a low lactate concentration with a concomitant increase in its oxidation in ...
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[6] Gingerol, from Zingiber officinale, potentiates GLP 1 mediated glucose stimulated insulin secretion pathway in pancreatic β cells and increases RAB8/RAB10 regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice
... potent insulin secreting, anti- hyperglycemic, lipid lowering, and anti-oxidant properties in a Lepr db/db type 2 diabetic mouse model [10], all of which are essential hallmarks of an effective anti-diabetic ...
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Role of Insulin in Endogenous Hypertriglyceridemia
... correlation existed between fasting plasma triglyceride concentration and either plasma glucose or free fatty acid concentrations after the high carbohydrate diet, nor was the degree of hypertriglyceridemia related to ...
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Influence of Basal Insulin and Glucagon Secretion on Potassium and Sodium Metabolism: STUDIES WITH SOMATOSTATIN IN NORMAL DOGS AND IN NORMAL AND DIABETIC HUMAN BEINGS
... basal insulin and glucagon secretion in potassium and sodium homeostasis, somatostatin, a potent inhibitor of insulin and glucagon secretion, was infused for 5 h into healthy human subjects, ...
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Potentiation of cholecystokinin induced exocrine secretion by both exogenous and endogenous insulin in isolated and perfused rat pancreata
... rat insulin (1-20 mU/ml) to the perfusing solution potentiated the action of cholecystokinin (CCK) (1 mU/ml) to increase both pancreatic juice flow and the release of the enzyme, ...increased endogenous ...
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THE PHYSIOLOGICAL SIGNIFICANCE OF THE SECRETION OF ENDOGENOUS INSULIN INTO THE PORTAL CIRCULATION III EVIDENCE FOR A DIRECT IMMEDIATE EFFECT OF INSULIN ON THE BALANCE OF GLUCOSE ACROSS THE LIVER
... Their failure to find a decrease in hepatic glucose output in the two other experiments in which a gradual decline in blood glucose concentration was produced by slow insulin infusion, m[r] ...
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Suppression of KATP channel activity protects murine pancreatic β cells against oxidative stress
... With respect to a therapeutic application, the experiments with gliclazide are promising because they show that protection of β cells against oxidative stress by upregulation of antioxidant enzymes is possible without ...
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